Molecular Biology of Diabetes

I. Autoimmunity and Genetics; Insulin Synthesis and Secretion

  • Boris Draznin
  • Derek LeRoith

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Molecular Mechanisms of Autoimmunity and Genetics of Diabetes

    1. Front Matter
      Pages N1-N1
    2. Massimo Pietropaolo, George S. Eisenbarth
      Pages 1-33
    3. Danling Gu, Nora Sarvetnick
      Pages 35-47
    4. Ronald G. Gill
      Pages 49-67
    5. Filippo Calcinaro, Dale R. Wegmann, Kevin J. Lafferty
      Pages 69-90
  3. Molecular and Cellular Aspects of Insulin Synthesis and Secretion

    1. Front Matter
      Pages N2-N2
    2. Michael S. German
      Pages 91-117
    3. Christopher B. Newgard, Sarah Ferber, Christian Quaade, John H. Johnson, Steven D. Hughes
      Pages 119-154
    4. Mark A. Magnuson, Kevin D. Niswender, Cathleen C. Pettepher
      Pages 155-174
    5. Guizhu Li, Prabakaran Kesavan, Habiba Najafi, Lijun Wang, Peter Ronner, Donna Berner et al.
      Pages 175-193
    6. R. Paul Robertson, L. Karl Olson, J. Bruce Redmon, Hui-Jian Zhang, Howard C. Towle
      Pages 195-212
    7. Deborah L. Bennett, John C. Hutton
      Pages 213-248
    8. Anjaneyulu Kowluru, Stewart A. Metz
      Pages 249-283
    9. Joseph S. Dillon, Ming Lu, Michael B. Wheeler, Aubrey E. Boyd III
      Pages 285-301
    10. Illani Atwater, Manuel Kukuljan, Elia Martha Pérez-Armendariz
      Pages 303-332
    11. Peter C. Butler, Norman L. Eberhardt, Timothy D. O’Brien
      Pages 381-398
  4. Back Matter
    Pages 399-404

About this book

Introduction

In a rapidly evolving and extremely important area of medical science, it is often difficult for the student, teacher, and researcher to keep abreast of all the important advances. The purpose of Molecular Biology ofDiabetes, Parts I and II is to bring to these individuals the latest knowledge of diabetes-related research in a comprehensive, yet concise manner. To this end, we have assembled chapters, written by most of the world's experts in the field, that we believe compre­ hensively survey and synthesize a coherent understanding of the subject. Studies of the etiology of type I and type II diabetes are extremely exciting and essential, since we hope to one day prevent the disease using gene therapy. These aspects are covered in Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion. In type II diabetes, an abnormality in pancreatic secretion exists concomitantly with peripheral insulin resistance. This abnor­ mality of insulin secretion is believed to be related to a defect(s) in glucose sensing. Uncoupling of glucose sensing from insulin secre­ tion may be the crucial step in the pathogenesis of noninsulin-depen­ dent diabetes. In this volume, we have invited authors to describe their studies on all known factors affecting ~-cell function, including autoimmunity and genetics of diabetes, as well as molecular mecha­ nisms of insulin synthesis and secretion. In the last few years, the most rapidly advancing area of research in diabetes has been, in fact, related to insulin action.

Keywords

Diabetes G proteins Insulin Insulin Secretion gene expression genes molecular biology molecular mechanisms signal transduction

Editors and affiliations

  • Boris Draznin
    • 1
  • Derek LeRoith
    • 2
  1. 1.University of Colorado Health Sciences CenterDenverUSA
  2. 2.National Institute of Diabetes and Digestive and Kidney DiseaseNational Institutes of HealthBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4612-0241-7
  • Copyright Information Humana Press Inc. 1994
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-6677-8
  • Online ISBN 978-1-4612-0241-7
  • About this book