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Endoscopic Management of Achalasia

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Surgical Management of Benign Esophageal Disorders

Abstract

Achalasia is an esophageal motility disorder characterized by impaired LES relaxation and absent peristalsis in the distal esophagus. Note, however, that absent peristalsis means that there is no progressively sequenced esophageal contraction; it does not imply the complete absence of esophageal contractions or intraluminal pressure. In fact, spastic contractions and panesophageal pressurization of the esophagus are often seen in patients with achalasia, and these criteria are now part of the Chicago classification for subtypes of achalasia (Bredenoord AJ, Fox M, Kahrilas PJ et al, Neurogastroenterol Motil:24(Suppl 1):57, 2012). The scope of endoscopic treatment for achalasia has also evolved over the past 5 years with the emergence of per-oral endoscopic myotomy.

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References

  1. Bredenoord AJ, Fox M, Kahrilas PJ, et al. Chicago classification criteria of esophageal motility disorders defined in high resolution esophageal pressure topography. Neurogastroenterol Motil. 2012;24 Suppl 1:57.

    Article  PubMed  Google Scholar 

  2. Goldblum JR, Whyte RI, Orringer MB, Appelman HD. Achalasia. A morphologic study of 42 resected specimens. Am J Surg Pathol. 1994;18:327.

    Article  PubMed  CAS  Google Scholar 

  3. Boeckxstaens GE. Achalasia: virus-induced euthanasia of neurons? Am J Gastroenterol. 2008;103:1610.

    Article  PubMed  Google Scholar 

  4. Behar J, Biancani P. Pathogenesis of simultaneous esophageal contractions in patients with motility disorders. Gastroenterology. 1993;105:111.

    PubMed  CAS  Google Scholar 

  5. Pandolfino JE, Kwiatek MA, Nealis T, et al. Achalasia: a new clinically relevant classification by high-resolution manometry. Gastroenterology. 2008;135:1526.

    Article  PubMed  Google Scholar 

  6. Tutuian R, Pohl D, Castell DO, Fried M. Clearance mechanisms of the aperistaltic oesophagus: the “pump gun” hypothesis. Gut. 2006;55:584.

    Article  PubMed  CAS  Google Scholar 

  7. Mayberry JF. Epidemiology and demographics of achalasia. Gastrointest Endosc Clin N Am. 2001;11:235.

    PubMed  CAS  Google Scholar 

  8. Kessing BF, Bredenoord AJ, Smout AJ. Erroneous diagnosis of gastroesophageal reflux disease in achalasia. Clin Gastroenterol Hepatol. 2011;9:1020.

    Article  PubMed  Google Scholar 

  9. Pandolfino JE, Kahrilas PJ. American Gastroenterological Association medical position statement: clinical use of esophageal manometry. Gastroenterology. 2005;128:207.

    Article  PubMed  Google Scholar 

  10. Ghosh SK, Pandolfino JE, Rice J, et al. Impaired deglutitive EGJ relaxation in clinical esophageal manometry: a quantitative analysis of 400 patients and 75 controls. Am J Physiol. 2007;293:G878.

    CAS  Google Scholar 

  11. Roman S, Zerbib F, Queneherve L, et al. The Chicago classification for achalasia in a French multicentric cohort. Dig Liver Dis. 2012;44:976.

    Article  PubMed  Google Scholar 

  12. Salvador R, Costantini M, Zaninotto G, et al. The preoperative manometric pattern predicts the outcome of surgical treatment for esophageal achalasia. J Gastrointest Surg. 2010;14:1635.

    Article  PubMed  Google Scholar 

  13. Pratap N, Reddy DN. Can achalasia subtyping by high-resolution manometry predict the therapeutic outcome of pneumatic balloon dilatation?: author’s reply. J Neurogastroenterol Motil. 2011;17:205.

    Article  PubMed  Google Scholar 

  14. Pasricha PJ, Rai R, Ravich WJ, Hendrix TR, Kalloo AN. Botulinum toxin for achalasia: long-term outcome and predictors of response. Gastroenterology. 1996;110:1410.

    Article  PubMed  CAS  Google Scholar 

  15. Patti MG, Feo CV, Arcerito M, et al. Effects of previous treatment on results of laparoscopic Heller myotomy for achalasia. Dig Dis Sci. 1999;44:2270.

    Article  PubMed  CAS  Google Scholar 

  16. Horgan S, Hudda K, Eubanks T, McAllister J, Pellegrini CA. Does botulinum toxin injection make esophagomyotomy a more difficult operation? Surg Endosc. 1999;13:576.

    Article  PubMed  CAS  Google Scholar 

  17. Smith CD, Stival A, Howell DL, Swafford V. Endoscopic therapy for achalasia before Heller myotomy results in worse outcomes than Heller myotomy alone. Ann Surg. 2006;243:579.

    Article  PubMed  Google Scholar 

  18. Spiess AE, Kahrilas PJ. Treating achalasia: from whalebone to laparoscope. JAMA. 1998;280:638.

    Article  PubMed  CAS  Google Scholar 

  19. Lynch KL, Pandolfino JE, Howden CW, Kahrilas PJ. Major complications of pneumatic dilation and Heller myotomy for achalasia: single-center experience and systematic review of the literature. Am J Gastroenterol. 2012;107:1817.

    Article  PubMed  Google Scholar 

  20. Farhoomand K, Connor JT, Richter JE, Achkar E, Vaezi MF. Predictors of outcome of pneumatic dilation in achalasia. Clin Gastroenterol Hepatol. 2004;2:389.

    Article  PubMed  Google Scholar 

  21. Boeckxstaens GE, Annese V, des Varannes SB, et al. Pneumatic dilation versus laparoscopic Heller’s myotomy for idiopathic achalasia. N Engl J Med. 2011;364:1807.

    Article  PubMed  CAS  Google Scholar 

  22. Pasricha PJ, Hawari R, Ahmed I, et al. Submucosal endoscopic esophageal myotomy: a novel experimental approach for the treatment of achalasia. Endoscopy. 2007;39:761.

    Article  PubMed  CAS  Google Scholar 

  23. Inoue H, Minami H, Kobayashi Y, et al. Peroral endoscopic myotomy (POEM) for esophageal achalasia. Endoscopy. 2010;42:265.

    Article  PubMed  CAS  Google Scholar 

  24. Inoue H, Kudo SE. [Per-oral endoscopic myotomy (POEM) for 43 consecutive cases of esophageal achalasia]. Nihon Rinsho. 2010;68:1749.

    PubMed  Google Scholar 

  25. von Renteln D, Inoue H, Minami H, et al. Peroral endoscopic myotomy for the treatment of achalasia: a prospective single center study. Am J Gastroenterol. 2012;107:411.

    Article  Google Scholar 

  26. Swanstrom LL, Rieder E, Dunst CM. A stepwise approach and early clinical experience in peroral endoscopic myotomy for the treatment of achalasia and esophageal motility disorders. J Am Coll Surg. 2011;213:751.

    Article  PubMed  Google Scholar 

  27. Hungness ES, Teitelbaum EN, Santos BF, Arafat FO, Pandolfino J, Soper NJ. Comparison of perioperative outcomes between peroral esophageal myotomy (POEM) and laparoscopic Heller myotomy. J Gastrointest Surg. 2013;17:228.

    Article  PubMed  Google Scholar 

  28. Vaezi MF, Baker ME, Richter JE. Assessment of esophageal emptying post-pneumatic dilation: use of the timed barium esophagram. Am J Gastroenterol. 1999;94:1802.

    Article  PubMed  CAS  Google Scholar 

  29. Vaezi MF, Baker ME, Achkar E, Richter JE. Timed barium oesophagram: better predictor of long term success after pneumatic dilation in achalasia than symptom assessment. Gut. 2002;50:765.

    Article  PubMed  CAS  Google Scholar 

  30. Eckardt VF, Aignherr C, Bernhard G. Predictors of outcome in patients with achalasia treated by pneumatic dilation. Gastroenterology. 1992;103:1732.

    PubMed  CAS  Google Scholar 

  31. Nicodème F, de Ruigh A, Xiao Y, et al. A comparison of symptom severity and bolus retention to Chicago classification esophageal topography metrics in achalasia. Clin Gastroenterol Hepatol. 2013;11:131.

    Article  PubMed  Google Scholar 

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Correspondence to Eric S. Hungness MD .

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Hungness, E.S., Kahrilas, P.J. (2014). Endoscopic Management of Achalasia. In: Fisichella, P., Soper, N., Pellegrini, C., Patti, M. (eds) Surgical Management of Benign Esophageal Disorders. Springer, London. https://doi.org/10.1007/978-1-4471-5484-6_11

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  • DOI: https://doi.org/10.1007/978-1-4471-5484-6_11

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