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Engineering Small Animal Conformal Radiotherapy Systems

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Engineering in Translational Medicine

Abstract

Small animal conformal radiotherapy platforms are important tools for translational research in the field of radiation oncology. It is crucial that the effects of radiotherapy on small animals are studied under the same conditions under which clinical radiotherapy is delivered. In this chapter, the engineering aspects of small animal radiotherapy systems, including the sources of radiation, beam collimation, and imaging techniques are described. An overview of the principal existing systems is given, and their current and future applications are discussed.

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Abbreviations

BLI:

Bioluminescence imaging

CBCT:

Cone-beam computed tomography

CT:

Computed tomography

DERT:

Dose-enhanced radiotherapy

IGRT:

Image-guided radiotherapy

kV:

Kilovoltage

LPS:

Lipopolysaccharides

MC:

Monte Carlo

MLC:

Multileaf collimator

MV:

Megavoltage

NPC:

Neural progenitor cells

NTCP:

Normal tissue complication probability

PDT:

Photodynamic therapy

SARRP:

Small animal radiation research platform

TCP:

Tumor control probability

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Stanford Universtiy, 875 Blake Wilbur, Stanford, CA, USA

    Magdalena Bazalova & Edward E. Graves

Authors
  1. Magdalena Bazalova
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  2. Edward E. Graves
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Corresponding author

Correspondence to Edward E. Graves .

Editor information

Editors and Affiliations

  1. Dept of Radiology/Medical Physics/Biomed, University of Wisconsin, Madison, USA

    Weibo Cai

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Bazalova, M., Graves, E.E. (2014). Engineering Small Animal Conformal Radiotherapy Systems. In: Cai, W. (eds) Engineering in Translational Medicine. Springer, London. https://doi.org/10.1007/978-1-4471-4372-7_31

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  • DOI: https://doi.org/10.1007/978-1-4471-4372-7_31

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  • Online ISBN: 978-1-4471-4372-7

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