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Abstract

The gastrointestinal tract is a long conduit, in practice an invagination, extending from the oral cavity to the anus. Digestion is perhaps the single word that best describes its function. However, to understand the behaviour we need to fragment the function. The food and fluid that are swallowed are transported to the stomach and intestines where mixing, secretion and absorption take place. The many subdivisions of the gastrointestinal tract each carry specialised sub-functions. For example, the oesophagus is largely a conduit through which the food and fluid is passed with practically no absorption and secretion taking place. The motor function has traditionally been studied by the motility research community; i.e., people with an interest in problems related to the transport function, and often with a background in biology and medicine.

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Literature

  • Bayliss, VM, Starling, EH. 1899. The movements and innervation of the small intestine. J Physiol, 24, 99–143.

    PubMed  CAS  Google Scholar 

  • Bayliss, VM, Starling, EH. 1901. The movements and innervation of the small intestine. JPhysiol, 26,125–38.

    CAS  Google Scholar 

  • Brasseur, JG. 1993. Mechanical studies of the esophageal function. Dysphagia, 8, 384–6.

    Article  PubMed  CAS  Google Scholar 

  • Cannon, WB. 1911. The Mechanical Factors of Digestion. Edward Arnold: London.

    Google Scholar 

  • Colstrup, H, Mortensen, J, Kristensen, K. 1983. A probe for measurement of related values of cross-sectional area and pressure. Urology Res, 11, 139–43.

    CAS  Google Scholar 

  • Fackler, K, Klein, L, Hiltner, A. 1981. Polarizing light microscopy of intestine and its relationship to mechanical behaviour. J Microscopy, 124, 305–11.

    Article  CAS  Google Scholar 

  • Frøbert, O, Gregersen, H, Bagger, JP. 1996. Mechanics of porcine coronary arteries ex vivo employing impedance planimetry: a new intravascular technique. Ann Biomed Eng, 24, 148–55.

    Article  PubMed  Google Scholar 

  • Frøbert, O, Mikkelsen, EO, Gregersen, H, Nyborg, NCB, Bagger, JP. 1996. Porcine coronary artery pharmacodynamics in vitro evaluated by a new intravascular technique. Relation to axial stretch. J Pharmacol Toxicol Methods, 36, 13–19.

    Article  PubMed  Google Scholar 

  • Frøbert, O, Schiønning, J, Gregersen, H, Baandrup, U, Petersen, JAK, Bagger, JP. 1997. Impaired human coronary artery distensibility by atherosclerotic lesions. A mechanical and histological investigation. Int JExp Pathol, 78, 421–8.

    Article  Google Scholar 

  • Fung, YC, Yih, CS. 1968. Peristaltic transport. J App Mech, 669–75.

    Google Scholar 

  • Fung, YC. 1993. Biomechanics. Mechanical Properties of Living Tissues. Springer-Verlag: New York.

    Google Scholar 

  • Gabella, G. 1984. Structural apparatus for force transmission in smooth muscles. Physiol Rev, 64, 455–77.

    PubMed  CAS  Google Scholar 

  • Gabella, G. 1987. Structure of muscles and nerves in the gastrointestinal tract. In: Physiology of the Gastrointestinal Tract, Second Edition, ed. Johnson, LR, Christensen, J, Jackson, MJ, Jacobson, ED, Walsh, JH, pp. 335–82. New York: Raven Press.

    Google Scholar 

  • Ginzel, KH. 1959. Investigations concerning the initiation of the peristaltic reflex in the guinea-pig ileum. J Physiol, 148, 75–6.

    Google Scholar 

  • Gregersen, H, Andersen, MB. 1991. Impedance measurement system for quantification of cross-sectional area in the gastrointestinal tract. Med Biol Eng Comput, 29, 108–10.

    Article  PubMed  CAS  Google Scholar 

  • Gregersen, H, Kassab, GS. 1996. Biomechanics of the gastrointestinal tract. Neurogastroenterol and Motil, 8, 277–97.

    Article  CAS  Google Scholar 

  • Gregersen, H, Christensen, J. 2000. Gastrointestinal tone. Neurogastroenterol and Motil, 12: 501–8.

    Article  CAS  Google Scholar 

  • Kosterlitz, HW, Robinson, JA. 1959. Reflex contractions of the longitudinal muscle coat of the isolated guinea-pig ileum. J Physiol, 146, 369–79

    PubMed  CAS  Google Scholar 

  • Li, M, Brasseur, JG, Kern, MK, et al. 1992. Viscosity measurements of barium sulfate mixtures for use in motility studies of the pharynx and esophagus. Dysphagia, 7, 17–30.

    Article  PubMed  CAS  Google Scholar 

  • Li, M, Brasseur, JG. 1993. Non-steady peristaltic transport in finite-length tubes. J Fluid Mech, 248, 129–51.

    Article  CAS  Google Scholar 

  • Macagno, E, Melville, J, Christensen, J. 1975. A model for longitudinal motility of the small intestine. Biorheology, 12, 369–76.

    PubMed  CAS  Google Scholar 

  • Macagno, EO, Christensen, J. 1980. Fluid mechanics of the duodenum. Ann Rev Fluid Mech, 12, 139–58.

    Article  Google Scholar 

  • Mall, F. 1896. A study of the intestinal contraction. Johns Hopkins Hosp Rep, 1, 37–75.

    Google Scholar 

  • Melville, J, Macagno, E, Christensen, J. 1975. Longitudinal contractions in the duodenum: their fluidmechanical function. Am J Physiol, 228, 1887–92.

    PubMed  CAS  Google Scholar 

  • Metry, S, Arhan, P, Chauvet, G. 1995. A mathematical analysis of intestinal peristaltic waves. Med Eng Phys, 17, 204–14.

    Article  PubMed  CAS  Google Scholar 

  • Meyer, JH, Gu, Y, Elashoff, J, Reedy, T, Dressman, J, Amidon, G. 1986. Effects of viscosity and fluid outflow on postcibal gastric emptying of solids. Am J Physiol, 250, G161–4.

    Google Scholar 

  • Miftakov, RN. 1994. Mathematical modeling of the peristaltic reflex: a numerical experiment. J Math Sci, 71, 2775–89.

    Article  Google Scholar 

  • Miftakhov, RN, Wingate, DL. 1994. Numerical simulation of the peristaltic reflex of the small bowel. Biorheology, 31, 309–25.

    PubMed  CAS  Google Scholar 

  • Miftakhov, RN, Abdusheva, GR, Christensen, J. 1999. Numerical simulation of motility patterns of the small bowel. Part I — formulation of a mathematical model. J Theor Biol 197, 89–112.

    Article  PubMed  CAS  Google Scholar 

  • Nothnagel, H. 1882. Zur chemischen reizung der glatten muskeln, zugleich als beitrag zur physiologie des darms. Arch Pathol Anat Physiol Klin Med, 88, 1–11.

    Google Scholar 

  • Orberg, J, Baer, E, Hiltner, J. 1983. Organization of collagen fibers in the intestine. Connect Tissue Res, 11, 285–97.

    Article  PubMed  CAS  Google Scholar 

  • Ren, J, Massey, BT, Dodds, WJ, et al. 1993. Determinants of the bolus pressure during esophageal peristaltic bolus transport. Am J Physiol, 264, G407–13.

    Google Scholar 

  • Schulze-Delrieu, K, Wall, JP. 1983. Determinants of flow across isolated gastroduodenal junctions of cats and rabbits. Am J Physiol, 245, G257–64.

    Google Scholar 

  • Schulze-Delrieu, K. 1992. Clearance patterns of the isolated guinea pig duodenum. Gastroenterology, 102, 849–56.

    PubMed  CAS  Google Scholar 

  • Srivastava, LM, Srivastava, VP, Sinha, SN. 1983. Peristaltic transport of a physiological fluid. Part I. Flow in non-uniform geometry. Biorheology, 20, 153–66.

    PubMed  CAS  Google Scholar 

  • Stavitsky, D, Macagno, EO, Christensen, J. 1981. Finite-element analysis of flow induced by contractions like those of the intestine. J Biomech, 14, 183–93.

    Article  PubMed  CAS  Google Scholar 

  • Tanko, L, Mikkelsen, EO, Frøbert, O, Bagger, JP, Gregersen, H. 1998. A new method for combined isometric and isobaric pharmacodynamics studies on porcine coronary arteries. Clin Exp Pharmacol Physiol, 25, 919–27;.

    Article  PubMed  CAS  Google Scholar 

  • Tanko, LB, Simonsen, U, Frøbert, O, Gregersen, H, Bagger, JP, Mikkelsen, EO. 2000. Vascular reactivity to nifedipine and Ca++ in vitro. The role of preactivation, wall tension and geometry. Eur J Pharmacol, 387, 305–14.

    Article  Google Scholar 

  • Tanko, LB, Simonsen, U, Matrougui, K, Gregersen, H, Frøbert, O, Bagger, JP, Mikkelsen, EO. 2001. Axial stretch modifies contractility of porcine coronary arteries by a protein kinase C-dependent mechanism. Pharmacol Toxicol, 88, 89–97.

    Article  PubMed  CAS  Google Scholar 

  • Tözeren, A, Özkaya, N, Tözeren, H. 1982. Flow of particles along a deformable tube. J Biomech, 15, 517–27.

    Article  PubMed  Google Scholar 

  • Trendelenburg, P. 1917. Physiologische and pharmacologische versuche über die dünndarmsperistaltik. Naunyn Schmiedebergs Arch Pharmacol, 81, 55–129.

    Article  Google Scholar 

  • Weems, WA. 1987. Intestinal fluid flow: Its production and control. In: Physiology of the Gastrointestinal Tract, ed. Johnson, LR, Christensen, J, Jackson, MJ, Jacobson, ED, Walsh, JH, pp. 571–93. New York: Raven Press.

    Google Scholar 

  • Yamada, H. 1970. Strength of Biological Materials. Baltimore: The Williams & Wilkins Company.

    Google Scholar 

  • Yuan, SY, Furness, JB, Bornstein, JC, Smith, TK. 1991. Mucosal distorsion by compression elicits polarized reflexes and enhances responses of the circular muscle to distension in the small intestine. J Autonom Nervous System, 35, 219–26.

    Article  CAS  Google Scholar 

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© 2003 Springer-Verlag London

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Gregersen, H. (2003). The Concept of Biomechanics. In: Biomechanics of the Gastrointestinal Tract. Springer, London. https://doi.org/10.1007/978-1-4471-3742-9_1

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  • DOI: https://doi.org/10.1007/978-1-4471-3742-9_1

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84996-880-5

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