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Immobilisation of Macromolecules for Obtaining Biocompatible Surfaces

  • Chapter
Immobilised Macromolecules: Application Potentials

Part of the book series: Springer Series in Applied Biology ((SSAPPL.BIOLOGY))

Abstract

The basis of this Chapter is a consideration of approaches utilised to improve the performance of surfaces in situations involving blood contact. The achievement of biocompatible surfaces is a principal feature of research and development relating to biomaterials, where a biomaterial is regarded as a material of synthetic or natural origin, used in contact with tissue, blood or biological fluid. An examination of the literature dealing with thrombosis and artificial surfaces (Forbes and Courtney 1987) reveals that references to the initiation of blood coagulation by foreign surfaces and the differences between the effect of an artificial surface and that of the normal endothelium reach back to 1819, while the application of biomaterials extends over a period of about 100 years (Williams 1987). Improvements in technology and clinical procedures have greatly intensified the long-standing interest in blood interactions with surfaces by increasing the number of biomaterials utilised and the range of applications.

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  1. J. M. Courtney
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  2. J. Yu
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  3. S. Sundaram
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  1. Zentrum für Ultrastrukturforschung, Universität für Bodenkultur, A-1180, Vienna, Austria

    U. B. Sleytr , P. Messner , D. Pum  & M. Sára , ,  & 

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Courtney, J.M., Yu, J., Sundaram, S. (1993). Immobilisation of Macromolecules for Obtaining Biocompatible Surfaces. In: Sleytr, U.B., Messner, P., Pum, D., Sára, M. (eds) Immobilised Macromolecules: Application Potentials. Springer Series in Applied Biology. Springer, London. https://doi.org/10.1007/978-1-4471-3479-4_12

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  • DOI: https://doi.org/10.1007/978-1-4471-3479-4_12

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