Abstract
The first report of surface-attached heparin was by Gott and co-workers in 1963 [1]. In this work, heparin was attached through formation of a complex with a quaternary ammonium salt which was adsorbed to graphite. The discovery of the thromboresistant properties of heparinized surfaces was inadvertent because the original intent of the work was to evaluate graphite. The graphite surface was treated with a quaternary ammonium salt to sterilize it, and the surface was rinsed in heparin as a simple precautionary measure. Gott’s work showed that the marked thromboresistance of the graphite-benzalkonium-heparin (GBH) surface was due to the presence of heparin attached at the surface. This method held the promise of enabling one to use foreign surfaces in contact with blood without systemic anticoagulation. However, in practice, the GBH coating could not be applied to flexible materials, and thus its use was limited.
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References
Gott, V. L., Whiffen, J. D., and Dutton, R. C., Science, 142, 1297 (1963).
Leininger, R. I., Cooper, C. W., Epstein, M. M., Falb, R. D., and Grode, G. A., ibid., 152, 1625(1966).
Falb, R. D., Grode, G. A., Luttinger, M., Epstein, M. M., Drake, B., and Leininger, R. I., Development of Blood-Compatible Polymeric Materials, U. S. Nat. Tech. Inform. Serv., PB Rept. No. 173, 053, 1966.
Falb, R. D., Grode, G. A., Grotta, H. M., Wright, R. A., Poirier, R. H., Takahashi, M. T., and Leininger, R. I., Development of Blood-Compatible Materials, U. S. Nat. Tech. Inform. Serv., PB Rept. Nos. 175, 668, 1967; 183, 317, 1967; 188, 108, 1968; and 188, 111, 1969.
Grode, G. A., et al., Biocompatible Materials for Use in the Vascular System, U. S. Nat. Tech. Inform. Serv., PB Rept. Nos. 188, 108, 1969; 195,727, 1970; and 205, 475, 1971.
Leininger, R. I., Falb, R. D., Crowley, J. P., and Grode, G. A., Trans. Amer. Soc. Artif. Intern. Organs, 18, 312 (1972).
Eriksson, J. C., Gillberg, G., and Lagergren, H., J. Biomed. Mater. Res., 1, 301 (1967).
Lagergren, H. and Eriksson, J. C., Trans. Amer. Soc. Artif. Intern. Organs, 17, 10 (1971).
Merrill, E. W., Salzman, E. W., Lipps, B. J., Jr., Gilliland, E. R., Austen, W. G., and Joison, J., ibid., 12, 139 (1966).
Salzman, E. W., Austen, W. G., Lipps, B. J., Jr., Merrill, E. W., and Joison, J., Surgery, 61, 1 (1967).
Merrill, E. W., Salzman, E. W., Wong, P.S.L., and Ashford, T. P., J. Appl. Physiol., 29, 723 (1970).
Halpern, B. D. and Shibakawa, R., in Interactions of Liquids at Solid Substrates, R. F. Gould, Ed., American Chemical Society, 1968.
Merker, R. L., Elyash, L. J., Mayhew, S. H., and Wang, J.Y.C., in Proceedings of the Artificial Heart Program Conference, R. J. Hegyeli, Ed., National Heart Institute Artificial Heart Program, Washington, D. C., 1969, p. 29.
Leonard, E. F., in Proceedings of the 5th Annual Contractors’ Conference of the Artificial Kidney Program of the National Institute of Arthritis and Metabolic Diseases, K. K. Krueger, Ed., Bethesda, Md., 1972, p. 184.
Gott, V. L., Ramos, M. D., Najjar, F. B., Allen, J. L., and Becker, K. E., in Proceedings of the Artificial Heart Program Conference, R. J. Hegyeli, Ed., National Heart Institute Artificial Heart Program, Washington, D. C., 1969, p. 181.
Rea, W. J., Whitley, D., and Eberle, J. W., Trans. Amer. Soc. Artif. Intern. Organs, 18, 316 (1972).
Kowarski, A., Thompson, R. G., Migeon, C. J., and Blizzard, R. M., J. Clin. Endocrinol., 30, 356 (1971).
Krause, A. H., Ferguson, T. B., and Weldon, C. S., Ann. Thorac. Surg., 14, 123 (1972).
Brenner, W. I., Engelman, R. M., Williams, C. D., Boyd, A. D., and Reed, G. E., Amer. J. Surg., 127, 555 (1974).
Mobin-Uddin, K., Utley, J. R., Bryant, L. R., Dillon, M., and Weiss, D. L., Ann. Thorac. Surg., 17, 351 (1974).
Salzman, E. W., Merrill, E. G., Binder, A., Wolf, C.F.W., Ashford, T. P., and Austen, W. G., J. Biomed. Mater. Res., 3, 69 (1969).
Falb, R. D., Takahashi, M. T., Grode, G. A., and Leininger, R. I., ibid., 1, 239 (1967).
Gentry, P. and Alexander, B., Biochem. Biophys. Res. Commun., 50, 500 (1973).
Thaler, E. and Schmer, G., Abstracts, 20th Annual Meeting of the American Society for Artificial Internal Organs, Chicago, Ill., April 3–5, 1974, p. 73.
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Falb, R.D. (1975). Surface-Bonded Heparin. In: Kronenthal, R.L., Oser, Z., Martin, E. (eds) Polymers in Medicine and Surgery. Polymer Science and Technology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7744-3_5
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DOI: https://doi.org/10.1007/978-1-4684-7744-3_5
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