Abstract
Pathology within the microvessels is poorly understood and is probably underestimated. Microvascular disease is very difficult to diagnose clinically, although some clues can be obtained from history, risk factors and neuroimaging. However, the diagnosis only can be established with certainty at autopsy. Moreover, autopsy, even with a thorough study of the vessels, often fails to demonstrate the mechanism of vascular occlusion. Various diseases may affect the microvasculature bed; in addition, aging may cause alterations in the small brain vessels and its effects are frequently associated with those of other vascular risk factors.
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References
Babikian V, Ropper AH (1987) Binswanger’s disease: a review. Stroke 18: 2–12
Brun A, Fredriksson K, Gustafson L (1992) Pure subcortical arteriosclerotic encephalopathy (Binswanger’s disease): a clinicopathologic study. Part 2: Pathologic features. Cerebrovasc Dis 2: 87–92
Caplan LR (1989) Intracranial branch atheromatous disease: a neglected, understudied, and underused concept. Neurology 39: 1246–1250
Caplan LR, Schoene WC (1978) Clinical features of subcortical arteriosclerotic encephalopathy (Binswanger’s disease). Neurology 28: 1206–1215
Davous P, Fallet-Bianco C (1991) Demence sous-corticale familiale avec leucoencephalopathie arteriopathique observation clinico-pathologique. Rev Neurol 147: 376–384
De Reuck J, Crevits L, De Coster W, Sieben G, van der Eecken H (1980) Pathogenesis of Binswanger chronic progressive subcortical encephalopathy. Neurology 30: 920–928
Dubas F, Gray F, Roullet E, Escourolle R (1985) Leucoencephalopathies arteriopathiques. Rev Neurol 141: 93–108
Fisher CM (1965) Lacunes: small, deep cerebral infarcts. Neurology 15: 774–784
Fisher CM (1969) The arterial lesions underlying lacunes. Acta Neuopathol 12: 1–15
Fisher CM (1977) Bilateral occlusion of basilar branches. J Neurol Neurosurg Psych 40: 1182–1189
Fisher CM (1991) Lacunar infarcts-a review. Cerebrovasc Dis 1: 311–320
Fisher CM, Caplan LR (1971) Basilar artery branch occlusion: a cause of pontine infarction. Neurology 21: 900–905
Fredriksson K, Brun A, Gustafson L (1992) Pure subcortical arteriosclerotic encephalopathy (Binswanger’s disease): a clinicopathologic study. Part 1: Clinical features. Cerebrovasc Dis 2: 82–86
Furuta A, Ishii N, Nishihara Y, Horie A (1991) Medullary arteries in aging and dementia. Stroke 22: 442–446
Gray F, Dubas F, Roullet E, Escourolle R (1985) Leucoencephalopathy in diffuse hemorrhagic cerebral amyloid angiopathy. Ann Neurol 18: 54–59
Grubb A, Jensson O, Gudmundsson G, Arnason A, Lofberg H, Malm J (1984) Abnormal metabolism of gamma-trace alkaline microprotein. The basic defect in hereditary cerebral hemorrhage with amyloidosis. New Engl J Med 311: 1547–1549
Haan J, Lanser JBK, Zijderveld I, van der Does IGF, Roos RAC (1990) Dementia in hereditary cerebral hemorrhage with amyloidosis - Dutch type. Arch Neurol 47: 965–967
Kinkel WR, Jacobs L, Polachini I, Bates V, Heffner RR (1985) Subcortical arteriosclerotic encephalopathy (Binswanger’s disease). Computed tomographic, nuclear magnetic resonance and clinical correlations. Arch Neurol 42: 951–959
Lotz PR, Ballinger WE, Quisling RG (1986) Subcortical arteriosclerotic encephalopathy: CT spectrum and pathologic correlation. AJNR 7: 817–822
Maruyama K, Ikeda SI, Ishihara T, Allsop D, Yanagisawa N (1990) Immunohistochemical characterization of cerebrovascular amyloid in 46 autopsied cases using antibodies to P protein and cystatin C. Stroke 21: 397–403
Mas JL, Dilouya A, de Recondo J (1992) A familial disorder with subcortical ischemic strokes, dementia, and leucoencephalopathy. Neurology 42: 1015–1019
Poirier J, Derouesne C (1984) Cerebral lacunae. A proposed new classification. Clin Neuropathol 3: 266
Regli F (1989) Cerebral amyloid angiopathy. In: Toole JF (ed) Handbook of clinical neurology. Vascular disease Part II Vol 10. Elsevier, Amsterdam, pp 333–344
Shimode K, Fujihara S, Nakamura M, Kobayashi S, Tsunematsu T (1991) Diagnosis of cerebral amyloid angiopathy by the enzyme-linked immunosorbent assay of cystatin C in cerebro-spinal fluid. Stroke 22: 860–866
Sonninen V, Savontaus ML (1987) Hereditary multi-infarct dementia. Eur Neurol 27: 209–215
Tournier-Lasserve E, Iba-Zizen MT, Romero N, Bousser MG (1991) Autosomal dominant syndrome with strokelike episodes and leukoencephalopathy. Stroke 22: 1297–1302
Tournier-Lasserve E, Joutel A, Melki J, Weissenbach J, Lathrop GM, Chabriat H, Mas JL, Cabanis EA, Baudrimont M, Maciazek J, Bach MA, Bousser MG (1993) Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy maps to chromosome 1912. Nature Genetics 3: 256–259
Verny M, Seilhean D, Duyckaerts C, Delaere P, Hauw JJ (1991) Vieillissement vasculaire cerebral (a l’exclusion de l’innervation). Ann Cardiol Angeiol 40: 301–308
Vinters HV (1987) Cerebral amyloid angiopathy. A critical review. Stroke 18: 311–324
Walinder J (1981) Multi-infarct dementia. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology. Neurogenetic directory. Elsevier, Amsterdam, pp 283–285
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Hommel, M., Gray, F. (1995). Microvascular Pathology. In: Caplan, L.R. (eds) Brain Ischemia. Springer, London. https://doi.org/10.1007/978-1-4471-2073-5_21
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DOI: https://doi.org/10.1007/978-1-4471-2073-5_21
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