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The Glutamate—Calcium Cascade

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Brain Ischemia

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Abstract

When glutamate is released from presynaptic terminals, it diffuses to the postsynaptic terminals where it binds to glutamate receptors, allowing Na+ influx that depolarizes the membrane. This opens Ca2+ channels allowing Ca2+ to enter the postsynaptic cell. Under ischemic conditions, this process becomes excessive—the “glutamate-calcium cascade”.

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    Eugene Gusev & Veronica I. Skvortsova

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Gusev, E., Skvortsova, V.I. (2003). The Glutamate—Calcium Cascade. In: Brain Ischemia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9248-2_5

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