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Role of Renin-Angiotensin System in Diabetic Heart Dysfunction and Changes in Phospholipase C Activity

  • Paramjit S. Tappia
  • Sushma A. Mengi
  • Naranjan S. Dhalla
Chapter
Part of the Progress in Experimental Cardiology book series (PREC, volume 8)

Abstract

The incidence of heart disease is greater in the diabetic population as compared to nondiabetics. Although cardiac abnormalities in diabetics are independent of coronary artery disease, hypertension and valvular disease, the molecular events underlying the con-tractile dysfunction of the heart during diabetes are incompletely defined. Since renin-angiotensin system is activated in diabetes, an accelerated generation of angiotensin II may be involved in the pathophysiological chain of events leading to diabetic cardiomyopathy. This article deals with the potential role of changes in phospholipase C-mediated signaling mech-anisms induced by activation of the renin-angiotensin system in diabetes. Such information will extend our knowledge in the field of heart disease due to diabetes and help in the devel-opment of new therapy for its treatment.

Key words

Diabetic cardiomyopathy Cardiac sarcolemma Phospholipase C Renin-angiotensin system Signal transduction mechanisms 

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Paramjit S. Tappia
    • 1
  • Sushma A. Mengi
    • 1
  • Naranjan S. Dhalla
    • 1
  1. 1.Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Departments of Human Nutritional Sciences and Physiology, Faculties of Human Ecology and MedicineUniversity of ManitobaWinnipegCanada

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