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Pharmacological Interventions

  • Chapter
Advanced Abnormal Psychology

Abstract

The use of psychotropic medications has increasingly become part of comprehensive treatment plans for children and adolescents. Due to the paucity of research, however, pediatric psychopharmacology is more an art than a science. Most rigorous pharmacological studies have focused on attention-deficit hyperactivity disorder (ADHD), and there are clear indications for stimulants as the primary therapy. However, there are fewer and less rigorous well controlled studies of antidepressants in children and adolescents, and even fewer in number and less well designed studies of antianxiety or anxiolytic medications. Thus, recommendations for using them in treatment are not as clear as for ADHD. Despite the lack of rigorous data, psychotropics are increasingly used. Factors contributing to this trend are diverse, including increasing severity of juvenile psychopathology, school mandates to educate youths who have serious psychiatric disorders, parents, and the inability of communities to manage their children's problems sufficiently, lack of appropriate alternative services, the availability of more effective medications that have relatively benign side effects, and pressure to contain costs from managed care.

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References

  • Addington, D. E., Jones, B., Bloom, D., Chouinard, G., Remington, G., & Albright, P. (1993). Reduction of hospital days in chronic schizophrenic patients treated with risperidone: A retrospective study. Clinical Therapy, 15, 917–926.

    Google Scholar 

  • Akiskal, H. S., Downs, J., Jordan, P., Watson, S., Daugherty, D., & Pruitt, D. B. (1985). Affective disorders in referred children and younger siblings of manic depressives. Archives of General Psychiatry, 42, 996–1003.

    Article  PubMed  Google Scholar 

  • American Academy of Pediatrics, Committee on Bioethics (1995). Informed consent, parental permission, and assent in pédiatrie practice. Pediatrics, 95, 314–317.

    Google Scholar 

  • Bernstein, G., Borchard, C, & Perwein, A. (1996). Anxiety disorders in children and adolescents: A review of the past ten years. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1110–1119.

    Article  PubMed  Google Scholar 

  • Biederman, J., Thisted, R. A., Greenhill, L. L., & Ryan, N. D. (1995). Estimation of the association between desipramine and the risk for sudden death in 5-to 14-year-old children. Journal of Clinical Psychiatry, 56, 87–93.

    PubMed  Google Scholar 

  • Birmaher, B., Ryan, N. D., Williamson, D. E., Brent, D. A., Kaufman, J., Dahl, R. E., Perel, J., & Nelson, B. (1996a). Childhood and adolescent depression: A review of the past 10 years. Part I. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1427–1439.

    Article  PubMed  Google Scholar 

  • Birmaher, B., Ryan, N. D., Williamson, D. E., Brent, D. A., & Kaufman, J. (1996b). Childhood and adolescent depression: A review of the past 10 years. Part II. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1575–1583.

    Article  PubMed  Google Scholar 

  • Birmaher, B., Waterman, G. S., Ryan, N., Cully, M., Balach, L., Ingram, J., & Brodsky, M. (1994). Fluoxetine for childhood anxiety disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 33, 993–999.

    Article  PubMed  Google Scholar 

  • Bradley, C. (1937). Behavior of children receiving benzedrine. American Journal of Psychiatry, 94, 577–585.

    Google Scholar 

  • Campbell, M., Silva, R. R., Kafantaris, V., Locascio, J. J., Gonzalez, N. M., Lee, D., & Lynch, N. S. (1991). Predictors of side effects associated with lithium administration in children. Psychopharmacology Bulletin, 27, 373–380.

    PubMed  Google Scholar 

  • Cantwell, D. P. (1996). Attention deficit disorder: A review of the past 10 years. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 978–987.

    Article  PubMed  Google Scholar 

  • Cantwell, D. P., Swanson, J., & Conners, D. F. (1997). Case study: Adverse response to clonidine. Journal of the American Academy of Child and Adolescent Psychiatry, 36(4), 539–544.

    Article  PubMed  Google Scholar 

  • Carlson, G. A., & Weintraub, S. (1993). Childhood behavior problems and bipolar disorder: Relationship or coincidence? Journal of Affective Disorders, 28, 143–153.

    Article  PubMed  Google Scholar 

  • Carrey, N. J., Wiggins, D. M., & Milin, R. P. (1996). Pharmacological treatment of psychiatric disorders in children and adolescents: Focus on guidelines for the primary care practitioner. Drugs, 51, 750–759.

    Article  PubMed  Google Scholar 

  • Cauffman, E., & Steinberg, L. (1995). The cognitive and affective influences on adolescent decision making. Temple Law Review, 68, 1763–1789.

    Google Scholar 

  • Chappell, P. B., Riddle, M. A., Scahill, L., Lynch, K. A., Schultz, R., Arnsten, A., Leckman, J. F., & Cohen, D. J. (1995). Guanfacine treatment of comorbid attention-deficit hyperactivity disorder and Tourette’s syndrome: Preliminary clinical experience. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 1140–1146.

    Article  PubMed  Google Scholar 

  • Committee on Bioethics (1995). Informed consent, parental permission, and assent in pédiatrie practice. The American Academy of Pediatrics, 95, 314–317.

    Google Scholar 

  • Conners, C. K., Casat, C. D., Gualtieri, C. T., Weller, E., Reader, M., Reiss, A., Weller, R. A., Khayrallah, M., & Ascher, J. (1996). Bupropion hydrochloride in attention deficit disorder with hyperactivity. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1314–1321.

    Article  PubMed  Google Scholar 

  • Dahl, R. E., Ryan, N. D., Puig-Antich, J., Nguyen, N. A., al-Shabbout, M, Meyer, V. A., & Perel, J. (1991). 24-hour cortisol measures in adolescents with major depression: A controlled study. Biological Psychiatry, 30(1), 25–36.

    Article  PubMed  Google Scholar 

  • DeVaugh-Geiss, J., Moroz, G., Biederman, J., Cantwell, D., Fontaine, R., Greist, J. H., Reichler, R., Katz, R.,’ Landau, P. (1992). Clomipramine hydrochloride in childhood and adolescent obsessive-compulsive disorder: A multicenter trial. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 45–49.

    Article  Google Scholar 

  • Dulcan, M. (1997). Practice parameters for the assessment and treatment of children, adolescents, and adults with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 56(10 Supplement), 85S–121S.

    Google Scholar 

  • Emslie, G. J., Rush, A. J., Weinberg, W. A., Kowatch, R. A., Hughes, C. W., Carmody, T., & Rintelmann, J. (1997). A double-blind, randomized, placebo-controlled trial of fluoxetine in children and adolescents with depression. Archives of General Psychiatry, 54, 1031–1307.

    Article  PubMed  Google Scholar 

  • Famularo, R., Kinscherff, R., & Fenton, T. (1988). Propranolol treatment for childhood posttraumatic stress disorder, acute type. A pilot study. American Journal of Diseases of Children, 142, 1244–1247.

    PubMed  Google Scholar 

  • Faraone, S. V., Biederman, J., Wozniak, J., Mundy, E., Mennin, D., & O’Donnell, D. (1997). Is comorbidity with ADHD a marker for juvenile-onset mania? Journal of the American Academy of Child and Adolescent Psychiatry, 36, 1046–1055.

    Article  PubMed  Google Scholar 

  • Feldman, H., Crumrine, P., Handen, B. L., Alvin, R., & Teodori, J. (1989). Methylphenidate in children with seizures and attention-deficit disorder. American Journal of Diseases of Children, 143, 1081–1086.

    PubMed  Google Scholar 

  • Ferreri, M., & Hantouche, E. G. (1998). Recent trials of hydroxyzine in generalized anxiety disorder. Ada Psychiatrica Scandinavica, Supplementum, 393, 102–108.

    Article  Google Scholar 

  • Gadow, K. D., Sverd, J., Sprafkin, J., Nolan, E. E., & Grossman, S. (1999). Long-term methylphenidate therapy in children with comorbid attention-deficit hyperactivity disorder and chronic multiple tic disorder. Archives of General Psychiatry, 56, 330–336.

    Article  PubMed  Google Scholar 

  • Garland, E. J. (1998). Intranasal abuse of prescribed methylphenidate. Journal of the American Academy of Child and Adolescent Psychiatry, 37, 1242–1243.

    Article  PubMed  Google Scholar 

  • Geller, B. (1997). Double-blind placebo-controlled study of lithium for adolescents with comorbid bipolar and substance dependency disorders. Presented at the Annual Midyear Institute of the American Academy of Child and Adolescent Psychiatry, March 19-21, Hamilton, Bermuda.

    Google Scholar 

  • Geller, B., Cooper, T. B., Chestnut, E. C, Abel, A. S., & Anker, J. A. (1984). Nortriptyline pharmacokinetic parameters in depressed children and adolescents: Preliminary data. Journal of Clinical Psychopharmacology, 4, 265–269.

    Article  PubMed  Google Scholar 

  • Geller, B., Cooper, T. B., & Chestnut, E. C. (1985). Serial monitoring and achievement of steady state nortriptyline plasma levels in depressed children and adolescents: Preliminary data. Journal of Clinical Psychopharmacology, 5, 213–216.

    PubMed  Google Scholar 

  • Geller, B., Cooper, T. B., Zimerman, B., Sun, K., Williams, M., & Frazier, J. (1994a). Double-blind placebo-controlled study of lithium for depressed children with bipolar family histories. Neumpsychopharmacology, 10(S-122), 541S.

    Google Scholar 

  • Geller, B., & Fetner, H. H. (1989). Children’s 24-hour serum lithium level after a single dose predicts initial dose and steady-state plasma level. Journal of Clinical Psychopharmacology, 9, 155.

    Article  PubMed  Google Scholar 

  • Geller, B., Fox, L. W., & Clark, K. A. (1994b). Rate and predictors of prepubertal bipolarity during follow-up of 6-to 12-year-old depressed children. Journal of the American Academy of Child and Adolescent Psychiatry, 33, 461–468.

    Article  PubMed  Google Scholar 

  • Geller, B., Fox, L. W., & Fletcher, M. (1993). Effect of tricyclic antidepressants on switching to mania and on the onset of bipolarity in depressed 6-to 12-year-olds. Journal of the American Academy of Child and Adolescent Psychiatry, 32, 43–50.

    Article  PubMed  Google Scholar 

  • Geller, B., & Luby, J. (1997). Child and adolescent bipolar disorder: A review of the past 10 years. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 1168–1176.

    Article  PubMed  Google Scholar 

  • Geller, B., Sun, K., Zimmerman, B., Luby, J., Frazier, J., & Williams, M. (1995). Complex and rapid-cycling in bipolar children and adolescents: A preliminary study. Journal of Affective Disorders, 34, 259–268.

    Article  PubMed  Google Scholar 

  • Goldman-Rakic, C. P., & Brown, R. M. (1982). Postnatal development of monoamine content and synthesis in the cerebral cortex of rhesus monkeys. Developmental Brain Research, 4, 339–349.

    Article  Google Scholar 

  • Grcevich, S. J., Findling, R. L., Rowane, W. A., Friedman, L., & Schulz, S. C. (1996). Risperidone in the treatment of children and adolescents with schizophrenia: A retrospective study. Journal of Child and Adolescent Psychopharmacology, 6, 251–257.

    Article  PubMed  Google Scholar 

  • Gutgesell, H., Atkins, D., Barst, R., Buck, M., Franklin, W, Humes, R., Ringel, R., Shaddy, R., & Taubert, K. A. (1999). Cardiovascular monitoring of children and adolescents receiving psychotropic drugs. Circulation, 99, 979–982.

    Article  PubMed  Google Scholar 

  • Hagino, O. R., Weiler, E. B., Weiler, R. A., Washing, D., Fristad, M. A., & Kontras, S. B. (1995). Untoward effects of lithium treatment in children aged four through six years. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 1584–1590.

    Article  PubMed  Google Scholar 

  • Hanna, G. L., Feibusch, E. L., & Albright, K. J. (1997). Buspirone treatment of anxiety associated with pharyngeal dysphasia in a four-year-old. Journal of the American Academy of Child and Adolescent Psychiatry, 7137–143.

    Google Scholar 

  • Harmon, R. J., & Riggs, P. D. (1996). Clonidine for posttraumatic stress disorder in preschool children. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1247–1249.

    Article  PubMed  Google Scholar 

  • Horrigan, J. P. (1996). Guanfacine for PTSD nightmares. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 975–976.

    Article  PubMed  Google Scholar 

  • Hyman, S. E., & Nestler, E. J. (1996). Initiation and adaptation: A paradigm for understanding psychotropic drug action. American Journal of Psychiatry, 153, 151–162.

    PubMed  Google Scholar 

  • Isojarvi, J. I., Laatikainen, T. J., Pakarinen, A. J., Juntunen, K. T., & Myllyla, V. V. (1993). Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. New England Journal of Medicine, 329, 1383–1388.

    Article  PubMed  Google Scholar 

  • Jakala, P., Riekkinen, M., Sirvio, J., Koivisto, E., Kejonen, K., Vanhanen, M, & Riekkinen, P., Jr. (1999). Guanfacine, but not clonidine, improves planning and working memory performance in humans. Neumpsychopharmacology, 20, 460–470.

    Article  Google Scholar 

  • Joshi, P. T., Hamel, L., Joshi, A. R., & Capozzoli, J. A. (1998). Use of droperidol in hospitalized children. Journal of the American Academy of Child and Adolescent Psychiatry, 37, 228–230.

    Article  PubMed  Google Scholar 

  • Kelly, D. L., Conley, R. R., Love, R. C, Horn, D. S., & Ushchak, C. M. (1998). Weight gain in adolescents treated with risperidone and conventional antipsychotics over six months. Journal of Child and Adolescent Psychopharmacology, 8, 151–159.

    Article  PubMed  Google Scholar 

  • King, R. A., Riddle, M. S., Chappell, P. B., Hardin, M. T., Anderson, G. M, Lombroso, P., & Scahill, L. (1991). Emergence of self-destructive phenomena in children and adolescents during fluoxetine treatment. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 179–186.

    Article  PubMed  Google Scholar 

  • Kingsbury, S. J., & Tekell, J. L. (1999). What are the advantages and disadvantages of using different providers for psychotherapy and drug treatment? Harvard Mental Health Letter, 15(11), 8.

    PubMed  Google Scholar 

  • Kolmen, B. K., Feldman, H. M., Handen, B. L., & Janosky, J. E. (1995). Naltrexone in young autistic children: A double-blind, placebo-controlled crossover study. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 223–231.

    Article  PubMed  Google Scholar 

  • Kovacs, M., & Gatsonis, C. (1994). Secular trends in age at onset of major depressive disorder in a clinical sample of children. Journal of Psychiatric Research, 28, 319–329.

    Article  PubMed  Google Scholar 

  • Kovacs, M., & Pollock, M. (1995). Bipolar disorder and comorbid conduct disorder in childhood and adolescence. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 715–723.

    Article  PubMed  Google Scholar 

  • Kuperman, S., & Stewart, M. A. (1987). Use of propranolol to decrease aggressive outbursts in younger patients. Open study reveals potentially favorable outcome. Psychosomatics, 28, 315–319.

    Article  PubMed  Google Scholar 

  • Leonard, H. L., March, J., Rickler, K. C, & Allen, A. J. (1997). Pharmacology of the selective serotonin reuptake inhibitors in children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 725–736.

    Article  PubMed  Google Scholar 

  • Leonard, H. L., Meyer, M. C, Swedo, S. E., Richter, D., Hamburger, S. D., Allen, A. J., Rapoport, J. L., & Tucker, E. (1995). Electrocardiographic changes during desipramine and clomipramine treatment in children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 1460–1468.

    Article  PubMed  Google Scholar 

  • Lombroso, P. J., Scahill, L., King, R. A., Lynch, K. A., Chappell, P. B., Peterson, B. S., McDougle, C. J., & Leckman, J. F. (1995). Risperidone treatment of children and adolescents with chronic tic disorders: A preliminary report. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 1147–1152.

    Article  PubMed  Google Scholar 

  • March, J., Biederman, J., Wolkow, R., & Safferman, A. (1998). Sertraline in children and adolescents with obsessive compulsive disorder: A multicenter double-blind placebo-controlled study. Journal of the American Medical Association, 280, 1752–1756.

    Article  PubMed  Google Scholar 

  • March, J. S., Kobak, K. A., Jefferson, J. W., Mazza, J., & Greist, J. H. (1990). A double-blind, placebo-controlled trial of fluroxamine versus impramine in outpatients with major depression. Journal of Clinical Psychiatry, 51, 200–202.

    PubMed  Google Scholar 

  • Myers, K., & McCauley, E. (1997). Treatment of depressive disorders during adolescence. In D. L. Dunner (Ed.), Current psychiatric therapy II, 2nd ed. (pp. 458–467). Philadelphia: W.B. Saunders.

    Google Scholar 

  • Neumann, P. J. (1999). Methods of cost-effectiveness analysis in the evaluation of new antipsychotics: Implications for schizophrenia treatment. Journal of Clinical Psychology, 60(Suppl 3), 9–14, discussion 15.

    Google Scholar 

  • Papatheodorou, G., & Kutcher, S. P. (1993). Divalproex sodium treatment in late adolescent and young adult acute mania. Psychopharmacology, 29, 213–219.

    Google Scholar 

  • Pfeffer, C. R., Jiang, H., & Domeshek, L. J. (1997). Buspirone treatment of psychiatrically hospitalized prepubertal children with symptoms of anxiety and moderately severe aggression. Journal of Child and Adolescent Psychopharmacology, 7, 145–155.

    Article  PubMed  Google Scholar 

  • Pizzuti, D. (1999, June). Cylert (pemoline) patient information/consent form. Abbott Pharmaceutical Products Division, 99F–110–6993A.

    Google Scholar 

  • Preskorn, S. H., Bupp, S. J., Weiler, E. B., & Weiler, R. A. (1989). Plasma levels of imipramine and metabolites in 68 hospitalized children. Journal of the American Academy of Child and Adolescent Psychiatry, 28, 373–375.

    Article  PubMed  Google Scholar 

  • Richman, N. (1985). A double-blind drug trial of treatment in young children with waking problems. Journal of Child Psychology and Psychiatry and Allied Disciplines, 26, 591–598.

    Article  Google Scholar 

  • Riddle, M. A., Brown, N., Dzubinski, D., Jetmalani, A. N., Law, Y., & Woolston, J. L. (1989). Fluoxetine overdose in an adolescent. Journal of the American Academy of Child and Adolescent Psychiatry, 23, 587–588.

    Article  Google Scholar 

  • Riddle, M. A., Claghorn, J., Gaffney, G., et al. (1996). Fluvoxamine for children and adolescents with OCD: A controlled multicenter trial. Presented at the 43rd Annual Meeting of the American Academy of Child and Adolescent Psychiatry, October 25, Philadelphia.

    Google Scholar 

  • Riddle, M. A., Nelson, J. C, Kleinman, C. S., Rasmusson, A., Leckman, J. F., King, R. A., & Cohen, D. J. (1991). Sudden death in children receiving Norpramin: A review of three reported cases and commentary. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 104–108.

    Article  PubMed  Google Scholar 

  • Riddle, M. A., Scahill, L., King, R. A., Hardin, M. T., Anderson, G. M., Ort, S. I., Smith, J. C, Leckman, J. F., & Cohen, D. J. (1992). Double-blind, crossover trial of fluoxetine and placebo in children and adolescents with obsessive-compulsive disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 1062–1069.

    Article  PubMed  Google Scholar 

  • Rosenberg, D. R., Stewart, C. M., Fitzgerald, K. D., Tawile, V., & Carroll, E. (1999). Paroxetine open-label treatment of pédiatrie outpatients with obsessive-compulsive disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 1180–1185.

    Article  PubMed  Google Scholar 

  • Rosenheck, R., Cramer, J., Allan, E., Erdos, J., Frisman, L. K., Xu, W., Thomas, J., Henderson, W., & Charney, D. (1999). Cost-effectiveness of clozapine in patients with high and low levels of hospital use. Department of Veterans Affairs Cooperative Study Group on clozapine in refractory schizophrenia. Archives of General Psychiatry, 56, 565–572.

    Article  PubMed  Google Scholar 

  • Ryan, N. D. (1992). The pharmacologie treatment of child and adolescent depression. Psychiatric Clinics of North America, 15, 29–40.

    PubMed  Google Scholar 

  • Ryan, N. D., Williamson, D. E., Iyengar, S., Orvaschel, H., Reich, T., Dahl, R. E., & Puig-Antich, J. (1992). A secular increase in child and adolescent onset affective disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 600–605.

    Article  PubMed  Google Scholar 

  • Safer, D. J., Zito, J. M., & Fine, E. M. (1996). Increased methylphenidate usage for attention deficit disorder in the 1990s. Pediatrics, 98, 1084–1088.

    PubMed  Google Scholar 

  • Schowalter, J. E. (1989). Psychodynamics and medication. Journal of the American Academy of Child and Adolescent Psychiatry, 28, 681–684.

    Article  PubMed  Google Scholar 

  • Schreier, H. A. (1998). Risperidone for young children with mood disorders and aggressive behavior. Journal of Child and Adolescent Psychopharmacology, 8(1), 49–59.

    Article  PubMed  Google Scholar 

  • Silva, R. R., Munoz, D. M, & Alpert, M. (1996). Carbamazepine use in children and adolescents with features of attention-deficit hyperactivity disorder: A meta-analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 352–358.

    Article  PubMed  Google Scholar 

  • Simeon, J., Dinicola, V. B., Ferguson, H. B., & Copping, W. (1990). Adolescent depression: A placebo controlled fluoxetine treatment study and follow-up. Progress in Neuropsychopharmacology and Biological Psychiatry, 14, 791–795.

    Article  Google Scholar 

  • Stein, D. J., Bouwer, C, Hawkridge, S., & Emsley, R. A. (1997). Risperidone augmentation of SSRIs in obsessive compulsive and related disorders. Journal of Clinical Psychiatry, 58(3), 119–122.

    Article  PubMed  Google Scholar 

  • Strober, M. (1992). Relevance of early age-of-onset in genetic studies of bipolar affective disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 606–610.

    Article  PubMed  Google Scholar 

  • Strober, M., Freeman, R., Rigali, J., Schmidt, S., & Diamond, R. (1992). The pharmacotherapy of depressive illness in adolescence: II. Effects of lithium augmentation in nonresponders to imipramine. Journal of the American cademy of Child and Adolescent Psychiatry, 31, 16–20.

    Article  Google Scholar 

  • Strober, M., Lampert, C, Schmidt, S., & Morrell, W. (1993). The course of major depressive disorder in adolescents: I. Recovery and risk of manic switching in a follow-up of psychotic and nonpsychotic subtypes. Journal of the American Academy of Child and Adolescent Psychiatry, 32, 34–42.

    Article  PubMed  Google Scholar 

  • Strober, M., Morrell, W., Burroughs, J., Lampert, C, Danforth, H., & Freeman, R. (1988). A family study of bipolar I disorder in adolescence: Early onset of symptoms linked to increased familial loading and lithium resistance. Journal of Affective Disorders, 15, 255–268.

    Article  PubMed  Google Scholar 

  • Strober, M., Morrell, W., Lampert, C, & Burroughs, J. (1990). Relapse following discontinuation of lithium maintenance therapy in adolescents with bipolar I illness: A naturalistic study. American Journal of Psychiatry, 147, 457–461.

    PubMed  Google Scholar 

  • Strober, M., Schmidt-Lackner, S., Freeman, R., Bower, S., Lampert, C, & DeAntonio, M. (1995). Recovery and relapse in adolescents with bipolar affective illness: A five-year naturalistic prospective follow-up. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 724–731.

    Article  PubMed  Google Scholar 

  • Thomas, C. R., & Holzer, C. E. (1999). National distribution of child adolescent psychiatrists. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 9–15.

    Article  PubMed  Google Scholar 

  • Varley, C. K., & McClellan, J. (1997). Case study: Two additional sudden deaths with tricyclic antidepressants. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 390–394.

    Article  PubMed  Google Scholar 

  • Wagner, K. D. (1999). Multisite study of paroxetine versus imipramine and placebo in the treatment of children and adolescents with major depression. Paper presented at Oregon Health Sciences University, June 18.

    Google Scholar 

  • Walsh, B. T, Greenhill, L. L., Giardina, E. V., Bigger, J. T., Waslick, B. D., Sloan, R. P., Bilich, K., Wölk, S., &

    Google Scholar 

  • Bagiella, E. (1999). Effects of desipramine on autonomie input to the heart. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 1186–1192.

    Article  PubMed  Google Scholar 

  • Weiss, G., Hechtman, L., Milroy, T., & Perlman, T. (1985). Psychiatric status of hyperactives as adults: A controlled prospective 15-year follow-up of 63 hyperactive children. Journal of the American Academy of Child and Adolescent Psychiatry, 24, 211–220.

    Article  Google Scholar 

  • Weithorn, L. A., & Campbell, S. B. (1982). The competency of children and adolescents to make informed treatment decisions. Child Development, 53, 1597–1598.

    Article  Google Scholar 

  • Weiler, E. B., Weller, R. A., & Fristad, M. A. (1995). Bipolar disorder in children: Misdiagnosis, underdiagnosis, and future directions. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 709–714.

    Article  Google Scholar 

  • Werry, J. S., & Aman, M. G. (1999). Practitioner’s guide to psychoactive drugs for children and adolescents, 2nd ed. New York: Plenum Medical Book.

    Google Scholar 

  • West, S. A., McElroy, S. L., Strkowski, S. M., Keck, P. E., Jr., & McConville, B. J. (1995). Attention deficit hyperactivity disorder in adolescent mania. American Journal of Psychiatry, 152, 271–273.

    PubMed  Google Scholar 

  • Wilens, T. E., Spencer, T. J., Swanson, J. M., Connor, D. F, & Cantwell, D. (1999). Combining methylphenidate and clonidine: A clinically sound medication option. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 614–619, discussion 619-622.

    Article  PubMed  Google Scholar 

  • Wilens, T. E., Biederman, J., Baldessarini, R. J., Geller, B., Schleifer, D., Spencer, T. J., Birmaher, B., & Goldblatt, A. (1996). Cardiovascular effects of therapeutic doses of tricyclic antidepressants in children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1491–1501.

    Article  PubMed  Google Scholar 

  • Wilens, T. E., Biederman, J., Baldessarini, R. J., Puopolo, P. R., & Flood, J. G. (1992). Developmental changes in serum concentrations of desipramine and 2-hydroxydesipramine during treatment with desipramine. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 691–698.

    Article  PubMed  Google Scholar 

  • Williams, D. T., Mehl, R., Yudofsky, S., Adams, D., & Roseman, B. (1982). The effect of propranolol on uncontrolled rage outbursts in children and adolescents with organic brain dysfunction. Journal of the American Academy of Child and Adolescent Psychiatry, 21, 129–135.

    Article  Google Scholar 

  • Wirshing, D. A., Wirshing, W. C, Kysar, L., Berisford, M. A., Goldstein, D., Pashdag, J., Mintz, J., & Marder, S. R. (1999). Novel antipsychotics: Comparison of weight gain liabilities. Journal of Clinical Psychiatry, 60, 358–363.

    Article  PubMed  Google Scholar 

  • Wozniak, J., Biederman, J., Kiely, K., Ablon, J. S., Faraone, S. V., Mundy, E., & Mennin, D. (1995). Mania-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 867–876.

    Article  PubMed  Google Scholar 

  • Yudofsky, S., Williams, D., & Gorman, J. (1981). Propranolol in the treatment of rage and violent behavior in patients with chronic brain syndromes. American Journal of Psychiatry, 138, 218–220.

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Child and Adolescent Treatment Program, Emanuel Hospital, Portland, Oregon, 97227, USA

    Keith Cheng

  2. Outpatient Child and Adolescent Psychiatry, Department of Psychiatry, Oregon Health Sciences University, Portland, Oregon, 97201, USA

    Kathleen Myers

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  1. Keith Cheng
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  2. Kathleen Myers
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Editor information

Editors and Affiliations

  1. Pacific University, Forest Grove, Oregon, USA

    Michel Hersen

  2. Nova Southeastern University, Fort Lauderdale, Florida, USA

    Vincent B. Van Hasselt

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© 2001 Springer Science+Business Media New York

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Cheng, K., Myers, K. (2001). Pharmacological Interventions. In: Hersen, M., Van Hasselt, V.B. (eds) Advanced Abnormal Psychology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8497-5_24

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  • DOI: https://doi.org/10.1007/978-1-4419-8497-5_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4631-9

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