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Irreversible Electroporation (IRE) on Liver Tumor Ablation: A Summary of Preclinical Translational Research

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Clinical Aspects of Electroporation

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Abstract

In the recent years the topic of irreversible electroporation has created an excitement in the ablation community due to its advantageous characteristics. In this chapter, we will explore these advantages such as complete cell death, demarcated ablation zones, quick procedure time, feasibility with real time imaging, and the lack of the “heat sink” effect that is affecting currently used ablation techniques such as radiofrequency ablation (RFA). Additionally, we will explore in depth the mechanism of IRE, preliminary research and our in vivo studies in a swine liver, and rabbit VX2 tumor model.

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Authors and Affiliations

  1. Ronald Reagan Medical Center at UCLA, Division of Interventional Radiology, Department of Radiology, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, RM2125, Los Angeles, CA, 90095, USA

    Stephen T. Kee

Authors
  1. Edward W. Lee
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  2. Daphne Wong
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  3. Stephen T. Kee
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Corresponding author

Correspondence to Stephen T. Kee .

Editor information

Editors and Affiliations

  1. Division of Interventional Radiology, Department of Radiology, Ronald Reagan Medical Center at UCLA, 757 Westwood Plaza, RM2125, Los Angeles, 90095, California, USA

    Stephen T. Kee

  2. , Department of Oncology, Copenhagen University Hospital Herlev, Herlev Ringvej 75, Herlev, 2730, Denmark

    Julie Gehl

  3. Division of Interventional Radiology, Department of Radiology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, B2-168 10833, Los Angeles, 90095, California, USA

    Edward W. Lee

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Lee, E.W., Wong, D., Kee, S.T. (2011). Irreversible Electroporation (IRE) on Liver Tumor Ablation: A Summary of Preclinical Translational Research. In: Kee, S., Gehl, J., Lee, E. (eds) Clinical Aspects of Electroporation. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8363-3_19

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  • DOI: https://doi.org/10.1007/978-1-4419-8363-3_19

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-8362-6

  • Online ISBN: 978-1-4419-8363-3

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