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Latrophilin Signalling in Tissue Polarity and Morphogenesis

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Adhesion-GPCRs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 706))

Abstract

Understanding the mechanisms that coordinate the polarity of cells and tissues during embryogenesis and morphogenesis is a fundamental problem in developmental biology. We have recently demonstrated that the putative neurotoxin receptor lat-1 defines a mechanism required for the alignment of cell division planes in the early embryo of the nematode C. elegans. Our analysis suggests that lat-1 is required for the propagation rather than the initial establishment of polarity signals. Similar to the role of the flamingo/CELSR protein family in the control of planar cell polarity, these results implicate an evolutionary conserved subfamily of adhesion-GPCRs in the control of tissue polarity and morphogenesis.

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Author information

Authors and Affiliations

  1. Institute of Physiology, University of Würzburg, 97070, Würzburg, Germany

    Tobias Langenhan

  2. Department of Biochemistry, University of Oxford, OX1 3QU, Oxford, UK

    Andreas P. Russ

Authors
  1. Tobias Langenhan
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  2. Andreas P. Russ
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Editor information

Editors and Affiliations

  1. Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

    Simon Yona PhD

  2. Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK

    Martin Stacey DPhil

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© 2010 Landes Bioscience and Springer Science+Business Media, LLC

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Langenhan, T., Russ, A.P. (2010). Latrophilin Signalling in Tissue Polarity and Morphogenesis. In: Yona, S., Stacey, M. (eds) Adhesion-GPCRs. Advances in Experimental Medicine and Biology, vol 706. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7913-1_3

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