Structure to Function

  • Simon Yona
  • Martin Stacey

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 706)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Helgi B. Schiöth, Karl J. V. Nordström, Robert Fredriksson
    Pages 1-13
  3. Tobias Langenhan, Andreas P. Russ
    Pages 37-48
  4. Hsi-Hsien Lin, Martin Stacey, Simon Yona, Gin-Wen Chang
    Pages 49-58
  5. John-Paul Silva, Yuri A. Ushkaryov
    Pages 59-75
  6. Natalie Strokes, Xianhua Piao
    Pages 87-97
  7. Gabriela Aust
    Pages 109-120
  8. Simon Yona, Hsi-Hsien Lin, Martin Stacey
    Pages 121-127
  9. Jörg Hamann, Henrike Veninga, Dorien M. de Groot, Lizette Visser, Claudia L. Hofstra, Paul P. Tak et al.
    Pages 128-137
  10. Ian Spendlove, Ruhcha Sutavani
    Pages 138-148
  11. Hsi-Hsien Lin, Martin Stacey, Joan Stein-Streilein, Siamon Gordon
    Pages 149-156
  12. Norikazu Mizuno, Hiroshi Itoh
    Pages 157-166
  13. Daeho Park, Kodi S. Ravichandran
    Pages 167-178
  14. Ben Davies, Christiane Kirchhoff
    Pages 179-188
  15. Back Matter
    Pages 189-199

About this book


Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation.


Adhesion Function GPCR Stacey Structure Yona leukocyte tissue

Editors and affiliations

  • Simon Yona
    • 1
  • Martin Stacey
    • 2
  1. 1.Department of ImmunologyThe Weizmann Institute of ScienceRehovotIsrael
  2. 2.Institute of Molecular and Cellular BiologyUniversity of LeedsLeedsUK

Bibliographic information