Adhesion-GPCRs pp 157-166 | Cite as

Signal Transduction Mediated through Adhesion-GPCRs

  • Norikazu Mizuno
  • Hiroshi Itoh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 706)


The signaling cascade of most adhesion-GPCRs remains uncharacterized, as the majority are still orphan receptors and further complicated by their unique structure containing a cleaved long extracellular domain (ECD) and a seven-transmembrane domain (7TM). In this chapter, we review previous reports which suggest G protein-dependent and -independent signaling pathways of adhesion-GPCRs and present our approach to investigate the signal transduction of the adhesion-GPCR, GPR56.


Thyrotropin Receptor Epidermal Growth Factor Domain GPR56 Signaling Secretin Family Mediate Cell Attachment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Norikazu Mizuno
  • Hiroshi Itoh
    • 1
  1. 1.Department of Cell BiologyNara Institute of Science and TechnologyNaraJapan

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