NF-κB, IκB Kinase and Interacting Signal Networks in Squamous Cell Carcinomas

  • Antonio Costanzo
  • Giulia Spallone
  • Michael KarinEmail author


Nuclear factor-κB (NF-κB) transcription factors and the IκB kinases (IKKs) that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-κB signaling also has a critical role in cancer development and progression. The canonical NF-κB pathway contributes to squamous cell carcinoma (SCC) development by interacting with other signaling pathways including tumor suppressive and oncogenic pathways in a tissue specific manner. In this chapter, we will summarize recent advances in the understanding of interconnections between NF-κB and IKKs, including IKKα which has NF-κB independent functions, in the context of SCC development and progression and as potential target for novel chemotherapy approaches.


Squamous Cell Carcinoma Squamous Cell Carcinoma Cell Line Human Squamous Cell Carcinoma HNSCC Cell RelA Phosphorylation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Antonio Costanzo
  • Giulia Spallone
  • Michael Karin
    • 1
    Email author
  1. 1.Laboratory of Gene Regulation and Signal Transduction, School of MedicineUniversity of California, San DiegoLa JollaUSA

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