Signaling Pathways in Squamous Cancer

  • Adam B. Glick
  • Carter Van Waes

Table of contents

  1. Front Matter
    Pages i-xx
  2. Barry L. Ziober, Joseph O. Humtsoe, Randall H. Kramer
    Pages 1-19
  3. Susan K. Repertinger, Justin G. Madson, Kyle J. Bichsel, Laura A. Hansen
    Pages 113-129
  4. Joyce E. Rundhaug, Susan M. Fischer
    Pages 131-147
  5. Christophe Cataisson, Stuart H. Yuspa
    Pages 149-164
  6. Antonio Costanzo, Giulia Spallone, Michael Karin
    Pages 201-222
  7. Dennis R. Roop, Maranke I. Koster
    Pages 241-259
  8. Sun M. Ahn, Seungwon Kim, Jennifer R. Grandis
    Pages 305-333
  9. Panomwat Amornphimoltham, Vyomesh Patel, Alfredo Molinolo, J. Silvio Gutkind
    Pages 407-429

About this book

Introduction

Squamous epithelia form the essential lining surface of tissues in contact with the environment, including the skin, and mucosa of the oral cavity, pharynx, larynx, esophagus, respiratory and genital tracts, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV light, tobacco smoke, and infectious agents. Consequently, squamous cell carcinomas that form in these tissues are among the most common human solid tumors, and have high morbidity and mortality. The signaling pathways that regulate epithelial homeostasis and the alterations in these pathways that arise during cancer development share certain features among these different tissue sites. This book brings together timely reviews from experts in the field on mechanisms and signaling pathways such as EGFR, TGF1, NFB, PPARs and mTOR/AKT that regulate development of squamous cancer in both human and experimental mouse models, with a focus on how these specific signaling pathways can be utilized as targets for anti-cancer therapy. This comprehensive monograph will be important for researchers wishing to enter the field, for medical students, and for established basic and clinical investigators who would gain from an overview of the field.

Keywords

Adam Glick Cancer Cancer Research Pathways Signaling Squamous

Editors and affiliations

  • Adam B. Glick
    • 1
  • Carter Van Waes
    • 2
  1. 1.Center for Molecular Toxicology &, CarcinogenesisPennsylvania State UniversityUniversity ParkUSA
  2. 2.National Institute on Deafness &, Other Communication DisordersNational Institute of HealthBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-7203-3
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4419-7202-6
  • Online ISBN 978-1-4419-7203-3
  • About this book