The Coronary Circulation
The relations between arterial pressure and flow in the coronary bed are under the influence of the humoral-nervous systems, and under local control, i.e., autoregulation. There is also the mechanical effect of the contracting cardiac muscle on coronary flow. Several other mutual interactions of smaller magnitude between the coronary vasculature and the cardiac muscle exist, which will be discussed below. The quantitative contribution of humoral and nervous control will not be discussed here. For a comprehensive description of coronary hemodynamics see refs. [1–3].
KeywordsCoronary Flow Fractional Flow Reserve Reactive Hyperemia Cardiac Contraction Coronary Vascular Resistance
- 4.Dankelman J, Spaan JAE, van der Ploeg CPB, Vergroesen I. Dynamic response of the coronary circulation to a rapid change in perfusion in the anaesthetised goat. J Physiol (Lond) 1989;419:703–715.Google Scholar
- 14.Gregg DE, Green HD. Registration and interpretation of normal phasic inflow into the left coronary artery by an improved differential manometric method. Am J Physiol 1940;130:114–125.Google Scholar
- 18.Willemsen MJ, Duncker DJ, Krams R, Dijkman M, Lamberts RR, Sipkema P, Westerhof N. Decrease in coronary vascular volume in systole augments cardiac contraction. Am J Physiol 2001;281:H731–H737.Google Scholar
- 24.Vis MA, Sipkema P, Westerhof N. Compression of intramyocardial arterioles during cardiac contraction is attenuated by accompanying venules. Am J Physiol 1997;273:H1002–H1011.Google Scholar
- 27.Lamberts RR, van Rijen MH, Sipkema P, Fransen P, Sys SU, Westerhof N. Increased coronary perfusion augments cardiac contractility in the rat through stretch-activated ion channels. Am J Physiol 2002;282:H1334–H1340.Google Scholar