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Stem Cells in the Treatment of Stroke

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Frontiers in Brain Repair

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 671))

Abstract

Stroke is an often devastating insult resulting in neurological deficit lasting greater than 24 hours. In the United States, stroke is the third leading cause of death. In those who do not succumb, any outcome from total recovery over a period of weeks to months to persistent profound neurological deficits is possible. Present treatment centers on the decision to administer tissue plasminogen activator, subsequent medical stabilization and early intervention with rehabilitation and risk factor management. The advent of stem cell therapy presents an exciting new frontier for research in stroke treatment, with the potential to cause a paradigm shift from symptomatic control and secondary prevention to reconstitution of neural networks and prevention of neuronal cell death after neurologic injury.

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Authors and Affiliations

  1. Department of Radiation Oncology, University of Michigan, UH B2C490, 1500 E. Medical Center Dr, Ann Arbor, Michigan, USA

    Klaudia Urbaniak Hunter

  2. Department of Neurological Surgery Barnes-Jewish Hospital, Washington University School of Medicine, St Louis, Missouri, USA

    Chester Yarbrough

  3. Division of Neurosurgery, UCSD Medical Center, San Diego, California, USA

    Joseph Ciacci

Authors
  1. Klaudia Urbaniak Hunter
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  2. Chester Yarbrough
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  3. Joseph Ciacci
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Correspondence to Klaudia Urbaniak Hunter .

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Editors and Affiliations

  1. Division of Neurosurgery, City of Hope Comprehensive Cancer Center & Beckman Research Institute, Duarte, California, USA

    Rahul Jandial MD, PhD

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Hunter, K.U., Yarbrough, C., Ciacci, J. (2010). Stem Cells in the Treatment of Stroke. In: Jandial, R. (eds) Frontiers in Brain Repair. Advances in Experimental Medicine and Biology, vol 671. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5819-8_9

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