Abstract
JM-1232(-), a newly manufactured isoindole derivative, shows sedative effect at a lower concentration compared with propofol. In the present study, we analyzed the response of the central respiratory activity to JM-1232(-). The brainstem-spinal cord of a newborn rat was isolated and was continuously superfused with oxygenated artificial cerebrospinal fluid (ACSF). Rhythmic inspiratory burst activity was recorded from C4 spinal ventral root using a glass suction electrode. We measured C4 burst rate and amplitude of integrated C4 activity. After obtaining a control recording, the preparation was superfused with ACSF containing JM-1232(-) at 10, 100 or 500 μM for 10 min. The application of both 10 and 100 μM JM-1232(-) did not decrease C4 burst rate significantly. However, 500 μM JM-1232(-) reduced C4 burst rate. On the contrary, C4 burst amplitude was not affected by the application of JM-1232(-) for 10 min at any concentrations. In conclusion, JM-1232(-) at a low concentration (but presumably higher than hypnotic dose), did not depress the central respiratory activity, whereas at a high concentration depression was seen.
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Acknowledgements
This work was Supported by Japan Society for the Promotion of Science KAKENHI (18791106 to Dr. Kuribayashi and 19603015 to Dr. Kuwana), Tokyo, Japan
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Kuribayashi, J., Kuwana, Si., Hosokawa, Y., Hatori, E., Takeda, J. (2010). Effect of JM-1232(-), a New Sedative on Central Respiratory Activity in Newborn Rats. In: Homma, I., Onimaru, H., Fukuchi, Y. (eds) New Frontiers in Respiratory Control. Advances in Experimental Medicine and Biology, vol 669. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5692-7_23
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DOI: https://doi.org/10.1007/978-1-4419-5692-7_23
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