New Frontiers in Respiratory Control

1. Front Matter

   Pages i-xxvi

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2. Part I Comparative Aspects

   1. Front Matter

      Pages 1-1

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   2. Evidence for a Distributed Respiratory Rhythm Generating Network in the Goldfish (Carsssius auratus)

      • Maryana Duchcherer, Andrew Kottick, R.J.A. Wilson

      Pages 3-7

   3. Fictive Lung Ventilation in the Isolated Brainstem Preparation of the Aquatic Frog, Xenopus Laevis

      • Naofumi Kimura

      Pages 9-12

3. Part II Development

   1. Front Matter

      Pages 13-13

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   2. Loss of Pre-Inspiratory Neuron Synchroneity in Mice with DSCAM Deficiency

      • Kenji Amano, Morimitsu Fujii, Satoru Arata, Masaharu Ogawa, Kazuhiro Yamakawa, Akiko Arata

      Pages 15-19

   3. Central Respiratory Failure in a Mouse Model Depends on the Genetic Background of the Host

      • Satoru Arata, Kenji Amano, Kazuhiro Yamakawa, Akiko Arata

      Pages 21-24

   4. Adrenaline Modulates on the Respiratory Network Development

      • Morimitsu Fujii, Akiko Arata

      Pages 25-28

   5. Ontogeny of Cl- Homeostasis in Mouse Hypoglossal Nucleus

      • Akihito Okabe, Akiko Arata, Yoshitaka Oku, Chitoshi Takayama, Atsuo Fukuda

      Pages 29-31

   6. Anatomical Changes of Phrenic Motoneurons During Development

      • Yasumasa Okada, Shigefumi Yokota, Yoshio Shinozaki, Fumikazu Miwakeichi, Yoshitaka Oku, Yukihiko Yasui

      Pages 33-36

   7. Postnatal Changes in Morphology and Dendritic Organization of Neurones Located in the Area of the Kölliker-Fuse Nucleus of Rat

      • Julia Reuter, Miriam Kron, Mathias Dutschmann

      Pages 37-41

4. Part III Modeling

   1. Front Matter

      Pages 43-43

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   2. Geometrical Analysis of Bursting Pacemaker Neurons Generated by Computational Models: Comparison to In Vitro Pre-Bötzinger Complex Bursting Neurons

      • Juan M. Cordovez, Christopher G. Wilson, Irene C. Solomon

      Pages 45-48

   3. Origami Model for Breathing Alveoli

      • HirHiroko Kitaoka, Carlos A. M. Hoyos, Ryuji Takaki

      Pages 49-52

   4. Biologically Variable Respiration as a Stochastic Process in Ventilation – a Stochastic Model Study

      • Kyongyob Min, Keita Hosoi, Masayuki Degami, Yoshinori Kinoshita

      Pages 53-55

   5. Future Perspectives – Proposal for Oxford Physiome Project

      • Yoshitaka Oku

      Pages 57-60

   6. Homeostatic Competition: Evidence of a Serotonin-Gated Spinoparabrachial Pathway for Respiratory and Thermoregulatory Interaction

      • Chi-Sang Poon

      Pages 61-65

   7. A Simplified Model for Explaining Negative Feedback to Beginners in Life Sciences

      • Masato Shibuya, Yoshitaka Oku, Ikuo Homma

      Pages 67-68

   8. Paradoxical Potentiation of Exercise Hyperpnea in Congestive Heart Failure Contradicts Sherrington Chemoreflex Model and Supports a Respiratory Optimization Model

      • Chung Tin, Karlman Wasserman, Neil S. Cherniack, Chi-Sang Poon

      Pages 69-72

5. Part IV Respiratory rhythm generation

   1. Front Matter

      Pages 73-73

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Breathing is performed by the rhythmic contraction of respiratory muscles. It ma- tains homeostasis of the organism by taking in the oxygen necessary to live and work and by controlling the level of CO within the organism. At first glance, breathing 2 seems simple; however, it is produced by a complex system in the brain with various afferents and efferents. The control of breathing is of the utmost importance in s- taining life, and although more than 150 years have passed since research on brea- ing control was first begun, many unsolved mysteries still remain. Breathing is like watching the tides at a beach that are created by the vast, complex open sea. The first Oxford Conference on Modeling and Control of Breathing was held 30 years ago in September of 1978 at the University Laboratory of Physiology in Oxford, England. During this first conference, the participants engaged in a hot d- cussion on the problem of whether breathing rhythm was produced by pacemaker cells or a neural network. This was before the discovery of the Bötinger complex in the medulla, and at the time, central chemoreceptive areas were still the focus of research. This conference was an especially unforgettable moment in the dawning of the new age of respiratory research. It has since been held every 3 years in various countries around the globe and is widely appreciated as the best respiratory meeting in the world.

• Respiratory Medicine
• brainstem
• chemoreception
• control of respiration
• neurons
• respiratory rhythm generation
• sleep apnea syndrome

From the review: “This volume in the Advances in Experimental Medicine and Biology series is an account of the proceedings of the XIth annual Oxford conference on modeling and control of breathing, which focused on respiratory control, held in Nara City, Japan, in 2009. … The book is very useful for specialists in pulmonary medicine and sleep disorders. It will be welcomed by the attendees of the conference and researchers in the fields of respiratory control, sleep disorders, exercise and respiratory control, respiratory muscle function, and respiratory failure.” (K. P. Ravikrishnan, Doody’s Review Service, July, 2010)

• Showa University School of Medicine, Tokyo, Japan

  Ikuo Homma, Hiroshi Onimaru

• Jyuntendo University School of Medicine, Tokyo, Japan

  Yoshinosuke Fukuchi

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