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Histiocytic Tumors

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Atlas of Pediatric Brain Tumors

Abstract

Represents a heterogeneous group of tumors and tumor-like masses commonly associated with histologically identical extracranial lesions. Broadly classified into two groups: Langerhans cell histiocytosis (LCH) and non-Langerhans cell histiocytosis (non-LCH). LCH results from clonal proliferation of dendritic cells with Langerhans cell characteristics; Previously known as Histiocytosis X that included entities such as eosinophilic granuloma, Hand-Schüller-Christian disease and Letterer-Siwe disease. LCH as currently defined may present as unifocal, multifocal (usually polyostotic), or disseminated disease.

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Suggested Reading

  • Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (ed) (2007) WHO Classification of Tumors of the central Nervous system, pp 193–196

    Google Scholar 

  • Da Costa CE, Szuhai K, Van Ejik R, Hoogeboom M et al (2009) No genomic aberrations in Langerhans cell histiocytosis as assessed by diverse molecular technologies: Genes chromosomes. Cancer 48(3):239–249

    Google Scholar 

  • Grois N, Prayer D, Prosch H, Lassmann H (2005) Neuropathology of CNS disease in Langerhans cell histiocytosis. Brain 128(4):829–838

    Article  PubMed  Google Scholar 

  • Weintraub M, Bhatia KG, Chandra RS, Magrath IT, Ladisch S (1998) p53 expression in Langerhans cell histiocytosis. J Pediatr Hematol Oncol 20(1):7–12

    Article  Google Scholar 

  • Beverly PC, Egeler RM, Arceci RR, Pritchard J (2005) The Nikolas Symphosia and histiocytosis. Natl Rev Cancer 5:488–494

    Article  Google Scholar 

  • Prayer D, Grois N, ProschH GH, Barkoviich AJ (2004) MR imaging presentation of intracranial disease associated with Langerhans cell histiocytosis. AJNR Am J Neuroradiol 25:880–891

    PubMed  Google Scholar 

  • Willis B, Abin A, Weinberg V, Zoger S, Wara WM, Matthay KK (1996) Disease course and late sequelae of Langerhans cell histiocytosis: 25 year experience at University of California, San Francisco. J Clin Oncol 14:2073–2082

    PubMed  CAS  Google Scholar 

  • Andriko JA, Morrison A, Colegial CH, Davis BJ, Jones RV (2001) Rosai-Dorfman disease isolated to the central Nervous system: A report of 11 cases. Mod Pathol 14(3):172–178

    Article  PubMed  CAS  Google Scholar 

  • Paulli M, Bergamaschi G, Tonon L, Viglio A, Rosso R, Facchetti F, Geerts ML (1995) Evidence of polyclonal nature of the cell infiltrate in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Br J Hematol 91(2):415–418

    Article  CAS  Google Scholar 

  • Weidauuer S, Stuckrad-Barre S, Dettmann E, Zanella FE, Lanfermann H (2003) Cerebral Erdheim-Chester disease: Case report and review of literature. Neuroradiology 45:241–245

    Article  Google Scholar 

  • Shinoda J, Murase S, Takenaka K, Sakai N (2005) Isolated central nervous system hemophagocytic lymphohistiocytosis: Case report. Neurosurgery 56:187

    PubMed  Google Scholar 

  • Lesniak MS, Viglione MP, Weingart J (2002) Multicentric parenchymal Xanthogranuloma in a child: case report and review of literature. Neurosurgery 51:1493–1498

    Article  PubMed  Google Scholar 

  • Sun W, Nordberg ML, Fowler MR (2003) Histiocytic sarcoma involving the central nervous system: clinical, immunohistochemical and molecular genetic studies of a case with review of literature. Am J Surg Pathol 27(3):258–265

    Article  PubMed  Google Scholar 

  • Hasselblatt M, Sepeehrnia A, Von Falkenhoausen M, Paulus W (2003) Intracranial follicular dendritic cell sarcoma: Case report. J Neurosurg 99:1089–1090

    Article  PubMed  Google Scholar 

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Mukherjee, A., Adesina, A.M. (2010). Histiocytic Tumors. In: Adesina, A., Tihan, T., Fuller, C., Poussaint, T. (eds) Atlas of Pediatric Brain Tumors. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1062-2_36

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  • DOI: https://doi.org/10.1007/978-1-4419-1062-2_36

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