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Complementary and Alternative Treatments for the Management of Cancer-Related Fatigue

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Alternative and Complementary Therapies for Cancer

Abstract

The National Comprehensive Cancer Network defines cancer-related fatigue (CRF) as “a persistent, subjective sense of tiredness related to cancer or cancer treatment that interferes with usual functioning.” [1] Based on this definition, there are two important components included in the measurement of CRF. The first is the subjective sense of tiredness or the descriptive expression of the symptom. The second is the impact of fatigue on various areas of functioning [2]. One of the distinguishing characteristics of CRF is that it is not relieved by sleep or rest [1], and patients report being “unusually” or overwhelmingly tired [3]. CRF affects multiple domains of an individual. In addition to the physical symptoms, CRF is also accompanied by negative affect or distress [1, 3].

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References

  1. Mock V, Atkinson A, Barsevick AM, Berger AM, Cimprich B, Eisenberger MA, Hinds P, Kaldor P, Otis-Greene SA, Piper BF. Cancer-related fatigue: Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. Nov 2007;5(10):1054–78.

    Google Scholar 

  2. Buchanan DR, O'Mara AM, Kelaghan JW, Sgambati M, McCaskill-Stevens W, Minasian L. Challenges and recommendations for advancing the state-of-the-science of quality of life assessment in symptom management trials. Cancer 2007;110(7):1621–8.

    Article  Google Scholar 

  3. Gutstein HB, The biologic basis of fatigue. Cancer 2001;92 Suppl 6:1678–83.

    Google Scholar 

  4. Lawrence DP, Kupelnick B, Miller K, Devine D, Lau J. Evidence report on the occurrence, assessment, and treatment of fatigue in cancer patients. J Natl Cancer Inst Monogr. 2004;32:40–50.

    Article  PubMed  Google Scholar 

  5. Mock V. Fatigue management: evidence and guidelines for practice. Cancer 2001;92 Suppl 6:1699–707.

    Google Scholar 

  6. Fulton C, Knowles G. Cancer fatigue. Eur J Cancer Care Engl. 2000;9(3):167–71.

    Google Scholar 

  7. Baker F, Denniston M, Smith T, West MM. Adult cancer survivors: how are they faring? Cancer 2005;104 Suppl 11:2565–76.

    Google Scholar 

  8. Bower JE, Ganz PA, Desmond KA, et al. Fatigue in long-term breast carcinoma survivors: a longitudinal investigation. Cancer 2006;106(4):751–8.

    Article  Google Scholar 

  9. Bower JE, Ganz PA, Desmond KA, Rowland JH, Meyerowitz BE, Belin TR. Fatigue in breast cancer survivors: occurrence, correlates, and impact on quality of life. J Clin Oncol. 2000;18(4):743–53.

    Google Scholar 

  10. Arndt V, Stegmaier C, Ziegler H, Brenner H. A population-based study of the impact of specific symptoms on quality of life in women with breast cancer 1 year after diagnosis. Cancer 2006;107(10):2496–503.

    Article  Google Scholar 

  11. Kurzrock R. The role of cytokines in cancer-related fatigue. Cancer 2001;92 Suppl 6:1684–8.

    Google Scholar 

  12. Evans WJ, Lambert CP. Physiological basis of fatigue. Am J Phys Med Rehabil. 2007;86 Suppl 1:S29–46.

    Article  PubMed  Google Scholar 

  13. Bower JE, Ganz PA, Aziz N. Altered cortisol response to psychologic stress in breast cancer survivors with persistent fatigue. Psychosom Med. 2005;67(2):277–80.

    Article  Google Scholar 

  14. Bower JE, Ganz PA, Aziz N, Olmstead R, Irwin MR, Cole SW. Inflammatory responses to psychological stress in fatigued breast cancer survivors: relationship to glucocorticoids. Brain Behav Immun. 2007;21(3):251–8.

    Article  Google Scholar 

  15. Bower JE, Ganz PA, Dickerson SS, Petersen L, Aziz N, Fahey JL. Diurnal cortisol rhythm and fatigue in breast cancer survivors. Psychoneuroendocrinology 2005;30(1):92–100.

    Article  PubMed  CAS  Google Scholar 

  16. Collado-Hidalgo A, Bower JE, Ganz PA, Cole SW, Irwin MR. Inflammatory biomarkers for persistent fatigue in breast cancer survivors. Clin Cancer Res. 2006;12(9):2759–66.

    Article  Google Scholar 

  17. Prue G, Rankin J, Allen J, Gracey J, Cramp F. Cancer-related fatigue: a critical appraisal. Eur J Cancer 2006;42(7):846–63.

    Article  Google Scholar 

  18. Mitchell SA, Beck SL, Hood LE, Moore K, Tanner ER. Putting evidence into practice: evidence-based interventions for fatigue during and following cancer and its treatment. Clin J Oncol Nurs. 2007;11(1):99–113.

    Article  PubMed  Google Scholar 

  19. Mitchell SA, Berger AM. Cancer-related fatigue: the evidence base for assessment and management. Cancer J. 2006;12(5):374–87.

    Article  Google Scholar 

  20. Mock V, Pickett M, Ropka ME, et al. Fatigue and quality of life outcomes of exercise during cancer treatment. Cancer Pract. 2001;9(3):119–27.

    Article  Google Scholar 

  21. Schwartz AL, Mori M, Gao R, Nail LM, King ME. Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. Med Sci Sports Exerc. 2001;33(5):718–23.

    Google Scholar 

  22. Cramp F, Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev. 2008(2):CD006145.

    Google Scholar 

  23. Schwartz AL, Meek PM, Nail LM, et al. Measurement of fatigue. determining minimally important clinical differences. J Clin Epidemiol. 2002;55(3):239–44.

    Article  Google Scholar 

  24. Jacobsen PB, Donovan KA, Vadaparampil ST, Small BJ. Systematic review and meta-analysis of psychological and activity-based interventions for cancer-related fatigue. Health Psychol. 2007;26(6):660–7.

    Article  Google Scholar 

  25. Minton O, Richardson A, Sharpe M, Hotopf M, Stone P. A systematic review and meta-analysis of the pharmacological treatment of cancer-related fatigue. J Natl Cancer Inst. 2008;100(16):1155–66.

    Article  Google Scholar 

  26. http://nccam.nih.gov/health/whatiscam/. Accessed December 1, 2008.

  27. Agteresch HJ, Dagnelie PC, van der Gaast A, Stijnen T, Wilson JH. Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst. 2000;92(4):321–8.

    Article  Google Scholar 

  28. Schumacher K, Schneider B, Reich G, et al. Influence of postoperative complementary treatment with lectin-standardized mistletoe extract on breast cancer patients. A controlled epidemiological multicentric retrolective cohort study. Anticancer Res. 2003;23(6D):5081–7.

    Google Scholar 

  29. Graziano F, Bisonni R, Catalano V, et al. Potential role of levocarnitine supplementation for the treatment of chemotherapy-induced fatigue in non-anaemic cancer patients. Br J Cancer 2002;86(12):1854–7.

    Article  Google Scholar 

  30. Yellen SB, Cella DF, Webster K, Blendowski C, Kaplan E. Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement system. J Pain Symptom Manage. 1997;13(2):63–74.

    Article  PubMed  CAS  Google Scholar 

  31. Cruciani RA, Dvorkin E, Homel P, et al. L-carnitine supplementation for the treatment of fatigue and depressed mood in cancer patients with carnitine deficiency: a preliminary analysis. Ann NY Acad Sci. 2004;1033:168–76.

    Article  Google Scholar 

  32. Lesser GJ, Case LD, Stark N, Williford SK, Giguere JK, Garino A, Naughton MJ, Vitolins M, Lively M, Shaw EG. A randomized double blind placebo-controlled study of oral coenzyme Q10 to relieve self reported cancer related fatigue in newly diagnosed BC patients. J Clin Oncol. 2010;28:7 s, (Abstract 9006).

    Google Scholar 

  33. Nicolson GL, Conklin KA. Reversing mitochondrial dysfunction, fatigue and the adverse effects of chemotherapy of metastatic disease by molecular replacement therapy. Clin Exp Metastasis 2008;25(2):161–9.

    Article  Google Scholar 

  34. Barton DL, Soori GS, Bauer BA, Sloan J, Johnson LA, Loprinzi CL. A pilot, multi-dose, placebo-controlled evaluation of American ginseng (panax quinquefolius) to improve cancer-related fatigue: NCCTG trial N03CA. J Clin Oncol. 2007;25(185):493 s.

    Google Scholar 

  35. Younus J, Simpson I, Collins A, Wang X. Mind control of menopause. Womens Health Issues 2003;13(2):74–8.

    Article  Google Scholar 

  36. Mendoza TR, Wang XS, Cleeland CS, et al. The rapid assessment of fatigue severity in cancer patients: use of the Brief Fatigue Inventory. Cancer 1999;85(5):1186–96.

    Article  Google Scholar 

  37. Carlson LE, Garland SN. Impact of mindfulness-based stress reduction (MBSR) on sleep, mood, stress and fatigue symptoms in cancer outpatients. Int J Behav Med. 2005;12(4):278–85.

    Article  Google Scholar 

  38. Nyenhuis DL, Yamamoto C, Luchetta T, Terrien A, Parmentier A. Adult and geriatric normative data and validation of the profile of mood states. J Clin Psychol. 1999;55(1):79–86.

    Article  PubMed  CAS  Google Scholar 

  39. Kim SD, Kim HS. Effects of a relaxation breathing exercise on fatigue in haemopoietic stem cell transplantation patients. J Clin Nurs. 2005;14(1):51–5.

    Article  Google Scholar 

  40. Piper BF. Piper fatigue scale available for clinical testing. Oncol Nurs Forum. 1990;17(5):661–2.

    Google Scholar 

  41. Moadel AB, Shah C, Wylie-Rosett J, et al. Randomized controlled trial of yoga among a multiethnic sample of breast cancer patients: effects on quality of life. J Clin Oncol. 2007;25(28):4387–95.

    Article  Google Scholar 

  42. Cohen L, Warneke C, Fouladi RT, Rodriguez MA, Chaoul-Reich A. Psychological adjustment and sleep quality in a randomized trial of the effects of a Tibetan yoga intervention in patients with lymphoma. Cancer 2004;100(10):2253–60.

    Article  Google Scholar 

  43. Danhauer SC, Tooze JA, Farmer DF, et al. Restorative yoga for women with ovarian or breast cancer: findings from a pilot study. J Soc Integr Oncol. Spring 2008;6(2):47–58.

    Google Scholar 

  44. Carson JW, Carson KM, Porter LS, Keefe FJ, Shaw H, Miller JM. Yoga for women with metastatic breast cancer: results from a pilot study. J Pain Symptom Manage. 2007;33(3):331–41.

    Article  Google Scholar 

  45. Morin CM, Bootzin RR, Buysse DJ, Edinger JD, Espie CA, Lichstein KL. Psychological and behavioral treatment of insomnia:update of the recent evidence (1998–2004). Sleep 2006;29(11):1398–1414.

    PubMed  Google Scholar 

  46. Berger A. Treating fatigue in cancer patients. Oncologist 2003;8 Suppl 1:10–14.

    Article  PubMed  Google Scholar 

  47. Buysse DJ, Reynolds CF III, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193–213.

    Article  PubMed  CAS  Google Scholar 

  48. Epstein DR, Dirksen SR. Randomized trial of a cognitive-behavioral intervention for insomnia in breast cancer survivors. Oncol Nurs Forum. 2007;34(5):E51–9.

    Article  Google Scholar 

  49. Barsevick AM, Dudley W, Beck S, Sweeney C, Whitmer K, Nail L. A randomized clinical trial of energy conservation for patients with cancer-related fatigue. Cancer 2004;100(6):1302–10.

    Article  Google Scholar 

  50. Forester B, Kornfeld DS, Fleiss JL. Psychotherapy during radiotherapy: effects on emotional and physical distress. Am J Psychiatry 1985;142(1):22–7.

    Google Scholar 

  51. Fawzy NW. A psychoeducational nursing intervention to enhance coping and affective state in newly diagnosed malignant melanoma patients. Cancer Nurs. 1995;18(6):427–38.

    Article  Google Scholar 

  52. Bar-Sela G, Atid L, Danos S, Gabay N, Epelbaum R. Art therapy improved depression and influenced fatigue levels in cancer patients on chemotherapy. Psychooncology 2007;16(11):980–4.

    Google Scholar 

  53. Spiegel D, Bloom JR, Yalom I. Group support for patients with metastatic cancer: a randomized outcome study. Arch Gen Psychiatry 1981;38(5):527–33.

    Article  Google Scholar 

  54. Given B, Given CW, McCorkle R, et al. Pain and fatigue management: results of a nursing randomized clinical trial. Oncol Nurs Forum. 2002;29(6):949–56.

    Article  Google Scholar 

  55. Gielissen MF, Verhagen CA, Bleijenberg G. Cognitive behaviour therapy for fatigued cancer survivors: long-term follow-up. Br J Cancer. 2007;97(5):612–18.

    Article  Google Scholar 

  56. Armes J, Chalder T, Addington-Hall J, Richardson A, Hotopf M. A randomized controlled trial to evaluate the effectiveness of a brief, behaviorally oriented intervention for cancer-related fatigue. Cancer 2007;110(6):1385–95.

    Article  Google Scholar 

  57. Ahles TA, Tope DM, Pinkson B, et al. Massage therapy for patients undergoing autologous bone marrow transplantation. J Pain Symptom Manage. 1999;18(3):157–63.

    Article  Google Scholar 

  58. Hernandez-Reif M, Field T, Ironson G, et al. Natural killer cells and lymphocytes increase in women with breast cancer following massage therapy. Int J Neurosci. 2005;115(4):495–510.

    Article  PubMed  Google Scholar 

  59. Post-White J, Kinney ME, Savik K, Gau JB, Wilcox C, Lerner I. Therapeutic massage and healing touch improve symptoms in cancer. Integr Cancer Ther. 2003;2(4):332–44.

    Article  Google Scholar 

  60. Tsang KL, Carlson LE, Olson K. Pilot crossover trial of Reiki versus rest for treating cancer-related fatigue. Integr Cancer Ther. 2007;6(1):25–35.

    Article  PubMed  CAS  Google Scholar 

  61. Roscoe JA, Matteson SE, Mustian KM, Padmanaban D, Morrow GR. Treatment of radiotherapy-induced fatigue through a nonpharmacological approach. Integr Cancer Ther. 2005;4(1):8–13.

    Article  PubMed  Google Scholar 

  62. Vickers AJ, Straus DJ, Fearon B, Cassileth BR. Acupuncture for postchemotherapy fatigue: a phase II study. J Clin Oncol. 2004;22(9):1731–5.

    Article  Google Scholar 

  63. Molassiotis A, Sylt P, Diggins H. The management of cancer-related fatigue after chemotherapy with acupuncture and acupressure: a randomised controlled trial. Complement Ther Med. 2007;15(4):228–37.

    Article  Google Scholar 

  64. Kohara H, Miyauchi T, Suehiro Y, Ueoka H, Takeyama H, Morita T. Combined modality treatment of aromatherapy, footsoak, and reflexology relieves fatigue in patients with cancer. J Palliat Med. 2004;7(6):791–6.

    Article  Google Scholar 

  65. Okuyama T, Akechi T, Kugaya A, et al. Development and validation of the cancer fatigue scale: a brief, three-dimensional, self-rating scale for assessment of fatigue in cancer patients. J Pain Symptom Manage. 2000;19(1):5–14.

    Article  PubMed  CAS  Google Scholar 

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Sood, A., Barton, D. (2010). Complementary and Alternative Treatments for the Management of Cancer-Related Fatigue. In: Alaoui-Jamali, M. (eds) Alternative and Complementary Therapies for Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0020-3_15

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  • DOI: https://doi.org/10.1007/978-1-4419-0020-3_15

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