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THE ACTIN CYTOSKELETON AND METASTASIS

  • Chapter
Cell Adhesion and Cytoskeletal Molecules in Metastasis

Part of the book series: Cancer Metastasis – Biology and Treatment ((CMBT,volume 9))

Abstract

Transformed cells require cell motility to invade adjacent and distant tissues. To move, cells need to operate a dynamic actin cytoskeleton to produce the necessary protrusions and forces that drive the cell forward. Several of the elements of the basic molecular machinery that assemble and operate the actin cytoskeleton have been identified and their function thoroughly characterized. Most of these elements are actin-binding proteins that can be controlled by a network of regulatory molecules that connects the actin cytoskeleton to higher cellular processes. In cancer cells the dynamics and regulation of the actin cytoskeleton may be corrupted at several levels. This review examines several aspects of the actin cytoskeleton that may be affected during transformation and tumor progression.

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Authors and Affiliations

  1. Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA

    Isaac Rabinovitz

  2. Department of Cell Biology, Harvard Medical School, Boston, MA, USA

    Kaylene J. Simpson

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  1. Isaac Rabinovitz
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  2. Kaylene J. Simpson
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  1. University of Arizona, Tucson, AZ, U.S.A.

    Anne E. Cress

  2. University of Arizona, Tucson, AZ, U.S.A.

    Raymond B. Nagle

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Rabinovitz, I., Simpson, K.J. (2006). THE ACTIN CYTOSKELETON AND METASTASIS. In: Cress, A.E., Nagle, R.B. (eds) Cell Adhesion and Cytoskeletal Molecules in Metastasis. Cancer Metastasis – Biology and Treatment, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5129-6_4

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