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Novel antihypertensive drugs: β-adrenoceptor antagonists and drugs with additional properties

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IUPHAR 9th International Congress of Pharmacology

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Abstract

β-Adrenoceptor blocking drugs were originally introduced into clinical medicine for the management of angina pectoris. However, it was soon discovered that pronethalol (Prichard, 1964) and propranolol (Prichard & Gillam, 1964) lowered blood pressure in patients with hypertension. This original finding has been confirmed many times, (although the exact mechanisms underlying this effect have never been satisfactorily elucidated), and β-adrenoceptor antagonists have become drugs of choice in the control of hypertension. These common, and potentially lucrative, indications are one of the reasons why many more β-adrenoceptor blocking drugs have been developed and marketed (Table 1). Although they share the common property of β-adrenoceptor antagonism and all have an antihypertensive effect, these drugs differ from one another both in terms of additional pharmacological properties, such as cardioselectivity, partial agonist activity and membrane stabilising activity and also in their pharmacokinetic characteristics.

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  1. Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, Scotland, UK

    D. G. McDevitt

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William Paton James Mitchell Paul Turner

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McDevitt, D.G. (1984). Novel antihypertensive drugs: β-adrenoceptor antagonists and drugs with additional properties. In: Paton, W., Mitchell, J., Turner, P. (eds) IUPHAR 9th International Congress of Pharmacology. Palgrave, London. https://doi.org/10.1007/978-1-349-86029-6_18

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