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Therapeutic Implication of Monoclonal Antibodies against Multidrug-Resistant Tumor Cells

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Therapeutic Monoclonal Antibodies

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Abstract

One of the major problems in cancer chemotherapy is the development of drug resistance during treatment. The nature of drug resistance in cancer patients is complex. One reason for the clinical resistance is the metabolic inactivation or excretion of anti-tumor agents by the liver, kidney, and other organs. In addition, tumor cells can acquire resistance to anticancer drugs. It is now generally accepted that drug resistance at the cellular level (cellular resistance) is also an important mechanism of drug resistance in patients.

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Authors
  1. Takashi Tsuruo
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  2. Hirofumi Hamada
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Editor information

Carl A. K. Borrebaeck James W. Larrick

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© 1990 Stockton Press

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Tsuruo, T., Hamada, H. (1990). Therapeutic Implication of Monoclonal Antibodies against Multidrug-Resistant Tumor Cells. In: Borrebaeck, C.A.K., Larrick, J.W. (eds) Therapeutic Monoclonal Antibodies. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-11894-6_7

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