Abstract
Specifically selected anti-idiotypic antibodies can be used for immunization in place of the nominal antigen. Aiming toward this, human monoclonal anti-idiotypic antibodies Mab2s) specific for a mouse monoclonal anticolon carcinoma antibody (Mab17-1A)(Ab1) were produced by Epstein-Barr virus (EBV)-immortalized cells (Steinitz et al., 1988b). Ten of these human IgGs, which inhibited the binding of Mab17-1A to colon carcinoma cells, bound to the same or to a close epitope in the combining site of Ab1. The Mab2s did not inhibit the binding of another mouse monoclonal antibody (M74) directed to the same molecule to which Mab17-1A was directed.
A purified fraction of anti-idiotypic antibodies (but not the mouse anti-human IgG fraction) from mice immunized with Mab2s was shown to contain antibodies that had binding specificity similar to Mab17-1A (i.e., anti-human colon carcinoma).
Selected human monoclonal anti-idiotypic antibodies may be successfully applied for active immunization against tumor-associated antigens in analogy to experimental systems.
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References
Bhattacharya-Chatterjee, M., Pride, M. W., Seon, B. K., and Kohler, H. (1987) J. Immunol. 139, 1354–1360.
Bona, C. A., Heber-Katz, E., and Paul, W. E. (1981) J. Exp. Med. 153, 951–967.
Egan, M. L., and Todd, C. W. (1972) J. Natl. Cancer Inst. 49, 887–889.
Francotte, M., and Urbain, J. (1984) J. Exp. Med. 160, 1485–1494.
Gaulton, G. N., Sharpe, A. H., Chang, D. W., Fields, B. N., and Greene, M. I. (1986) J. Immunol. 137, 2930–2936.
Göttlinger, H. G., Funke, I., Johnson, J. P., Gokel, J. M., and Riethmüller, G. (1986) Int. J. Cancer. 38, 47–53.
Herlyn, D., Ross, A. H., and Koprowski, H. (1986) Science 232, 100–102.
Herlyn, M., Steplewski, Z., Herlyn, D., and Koprowski, H. (1979) Proc. Natl. Acad. Sci. USA 76, 1438–1452.
Huang, J. Y., Ward, R. E., and Kohler, H. (1986) J. Immunol. 137, 770–776.
Huang, J. Y., Ward, R. E., and Kohler, H. (1988) Immunol. 63, 1–8.
Hunter, W. M., and Greenwood, F. C. (1962) Nature 194, 495–496.
Koprowski, H., Herlyn, D., Lubeck, M., DeFreitas, E., and Sears, H. F. (1984) Proc. Natl. Acad. Sci. USA 81, 216–219.
Lee, V. K., Harriott, T. G., Kuchroo, V. K., Halliday, W. J., Hellström, I., and Hellström, K. E. (1985) Proc. Natl. Acad. Sci. USA 82, 6286–6290.
Nepom, G. T., Nelson, K. A., Holbeck, S. L., Hellström, I., and Hellström, K. E. (1984) Proc. Natl. Acad. Sci. USA 81, 2864–2867.
Raychaudhuri, S., Saeki, Y., Fuji, H., and Kohler, H. (1986) J. Immunol. 137, 1743–1749.
Raychaudhuri, S., Saeki, Y., Chen, J. J., Iribe, H., and Kohler, H. (1987a) J. Immunol. 139, 271–278.
Raychaudhuri, S., Saeki, Y., Chen, J. J., and Kohler, H. (1987b) J. Immunol. 139, 3902–3910.
Steinitz, M., Koide, M., Spira, G., Tamir, S., and Klein, G. (1982) Cell. Immunol. 69, 205–214.
Steinitz, M., Tamir, S., Bar Sela, S., and Rosenmann, E. (1988a) Cell. Immunol. 113, 10–19.
Steinitz, M., Tamir, S., Frodin, J. E., Lefvert, A. K., and Mellstedt, H. (1988b) J. Immunol. 141, 3516–3522.
Sy, M. S., Bach, B. A., Dohl, Y., Nisonoff, A., Benaceraf, B., and Greene, M. I. (1979) J. Exp. Med. 150, 1216–1228.
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Steinitz, M., Tamir, S., Frödin, JE., Mellstedt, H. (1990). Human Monoclonal Anti-Idiotypic Antibodies against a Murine Monoclonal Antibody (Mab17-1A) as an Anti-Tumor Vaccine. In: Borrebaeck, C.A.K., Larrick, J.W. (eds) Therapeutic Monoclonal Antibodies. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-11894-6_10
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DOI: https://doi.org/10.1007/978-1-349-11894-6_10
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