Abstract
In attempting to understand the mechanism by which a toxic agent interferes with the normal functioning of cells, studies may be carried out at at least three levels: (i) an anatomical level, with a description of the changes in tissues, cells or cell components; (ii) a chemical level, with cytochemical techniques used in situ or studies in vitro on separate cellular constituents; (iii) a genetical level, with a follow-up of the offspring of treated animals, or of treated cells. Though some poisons are equally toxic for all cells, most are more toxic for one type of cell than another. It is only by the use of several experimental systems, multicellular, single-cell or sub-cellular, that the reason for such differences can be discovered.
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Ord, M. J. (1970). T. cell Sci., in the Press
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Ord, M. J. & Bell, L. G. E. (1970). Nature, Land., 226, 854
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© 1971 Institute of Biology Endowment Fund
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Ord, M.J. (1971). Amoeba Proteus as a Cell Model in Toxicology. In: Aldridge, W.N. (eds) A Symposium on Mechanisms of Toxicity. Biological Council. Palgrave, London. https://doi.org/10.1007/978-1-349-01085-1_12
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DOI: https://doi.org/10.1007/978-1-349-01085-1_12
Publisher Name: Palgrave, London
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