Abstract
Visual processing involves the retina, thalamus, and primary visual cortex and cognitive response to visual information involves the integration of various cortical regions. Measures of infant visual acuity have focused on two main aspects of the visual system; retinal development using electroretinogram (ERG) and visual processing at the level of the primary visual cortex. Visual evoked potential (VEP) and behavioral assessments such as the forced-choice preferential looking are two measures involving processing at or beyond the level of the primary visual cortex. VEP measures cortical response directly and has less inherent variability. Forced-choice preferential looking procedures provide insight regarding the integration of visual information beyond the primary visual cortex. The retinal photoreceptors and the gray matter of the cortex have high docosahexaenoic acid (DHA, 22:6 n-3) content. The majority of research investigating functional outcomes in human infants has repeatedly demonstrated better visual function related to the provision of DHA during the prenatal and postnatal periods in comparison to infants who were not supplemented. Multiple independent research groups have documented that pregnant women have DHA intakes well below current recommendations. In turn, DHA deficits during the prenatal period place the developing fetus at risk for interruptions in visual system development. Although breast milk is the best source of DHA for infants during the postnatal period DHA supplementation is necessary for formula-fed infants. The three main sources of DHA and arachidonic acid oil considered used in infant formulas: marine, egg phospholipid, and single-cell oils. Of the three, single-cell oils are the most efficacious for supplementation of formula-fed infants and women of child-bearing age. Increased efforts toward community-based educational programs targeting women of child-bearing age aimed to increase DHA intake are highly important. Interruptions in visual development can delay the achievement of other developmental milestones with important long-term implications.
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Abbreviations
- ACP:
-
Acuity card procedure
- ARASCO:
-
Arachidonic acid single-cell oil
- DHA:
-
Docosahexaenoic acid
- DHASCO:
-
Docosahexaenoic acid single-cell oil
- ERG:
-
Electroretinogram
- FPL:
-
Forced-choice preferential looking
- GPCR:
-
G-protein coupled reaction
- Kg:
-
Kilogram
- LCPUFA:
-
Long chain polyunsaturated fatty acid
- Mg:
-
Milligrams
- SCO:
-
Single-cell oil
- VEP:
-
Visual evoked potential
References
Auestad N, Innis SM. Am J Clin Nutr. 2000;71:312S–4.
Auestad N, Montalto MB, Hall RT, Fitzgerald KM, Wheeler RE, Connor WE, et al. Pediatr Res. 1997;41:1–10.
Auestad N, Halter R, Hall RT, Blatter M, Bogle ML, Burks W, et al. J Pediatr. 2001;108:372–81.
Bazan NG, Scott BL. J Med Sci. 1990;48:97–107.
Bertenthal BI. Annu Rev Psychol. 1996;47:431–59.
Birch E, Birch DG, Hoffman D. J Pediatr Opthalmol Strabismus. 1993a;30:33–8.
Birch E, Birch DG, Hoffman D, Everett M, Uauy R. J Pediatr Ophthalmol Strabismus. 1993b;30:33–8.
Birch EE, Garfield S, Hoffman DR, Uauy R, Birch DG. Dev Med Child Neurol. 2000;42:174–81.
Boswell K, Koskelo EK, Carl L, Glaza S, Hensen DJ, Williams KD, et al. Food Chem Toxicol. 1996;34:585–93.
Bowen RA, Clandinin MT. J Neurochem. 2002;83:764–74.
Carlson SE, Werkman SH. Lipids. 1996;31:85–90.
Carlson SE, Cooke R, Werkman S, Tolley EA. Lipids. 1992a;27:901–7.
Carlson SE, Cooke RJ, Rhodes JM, Peeples J, Werkman SH. J Pediatr. 1992b;120:159–67.
Carlson SE, Werkman S, Peeples JM, Cooke RJ, Tolley EA. Proc Natl Acad Sci. 1993;90:1073–7.
Carlson SE, Ford AJ, Werkman SH, Peeples JM, Koo WK. Pediatr Res. 1996;39:882–8.
Cheruku SR, Montgomery-Downs HE, Farkas SL, Thoman EB, Lammi-Keefe CJ. Am J Clin Nutr. 2002;76:608–13.
Clandinin MT, CJ LS, Heim T, Sawyer PR, Chance GW. Early Hum Dev. 1980;4:121–9.
Denomme J, Stark KD, Holub BJ. J Nutr. 2005;135(2):206–11.
Fox P. Fetal and neonatal physiology, vol 1. Philadelphia: W.B. Saunders Company; 1998. p. 489–504.
Hoffman DR, Birch EE, Castaneda YS, Fawcett SL, Wheaton DH, Birch DG, et al. J Pediatr. 2003;142:669–77.
Innis SM, Elias SL. Am J Clin Nutr. 2003;77:473–8.
Innis SM, Nelson CM, Rioux FM, King JD. Am J Clin Nutr. 1994;60:347–52.
Innis SM, Nelson CM, Lwanga D, Rioux FM, Walsen P. Am J Clin Nutr. 1996;64:40–6.
Innis SM, Akrabawi SS, Diersen-Schade DA, Dobson VM, Guy DG. Lipids. 1997;32:63–72.
Jorgensen HM, Hernell O, Lund P, Holmer G, Michaelsen KF. Lipids. 1996;31:99–105.
Judge MP, Harel O, Lammi-Keefe CJ. Lipids. 2007;42:117–22.
Kellman PJ, Banks MS. Infant visual perception. In: Kuhn D, Siegler RS, editors. Handbook of child psychology: cognition, perception, and language, vol 2. New York: Wiley; 1998. p. 103–46.
Kolb B, Whishaw IQ. Organization of the nervous system. In: Atkinson RC, Lindzey G, Thompson RF, editors. Fundamentals of human neuropsychology. New York: Worth Publishers; 2003. p. 46–74.
Koletzko B, Lien E, Agostoni C, Böhles H, Compoy C, Cetin I, et al. J Perinat Med. 2008;36:5–14.
Lewis NM, Widga AC, Buck JS, Frederick AM. J Agromedicine. 1995;2:49–56.
Loosemore ED, Judge MP, Lammi-Keefe CJ. Lipids. 2004;39:421–4.
Makrides M, Simmer K, Goggin M, Gibson RA. Pediatr Res. 1993;33:425–7.
Makrides M, Neumann M, Simmer K, Pater J, Gibson R. Lancet. 1995;345:1463–8.
Malcolm CA, Hamilton R, McCulloch DL, Montgomery C, Weaver LT. Invest Opthalmol Vis Sci. 2003a;44:3685–91.
Malcolm CA, McCulloch DL, Montgomery C, Shepherd A, Weaver LT. Arch Dis Child Fetal Neonatal Ed. 2003b;88:F383–90.
Mitchell DC, Niu SL, Litman BJ. J Pediatr. 2003;143:880–6.
Neuringer M. Am J Clin Nutr. 2000;71:256S–67.
Neuringer M, Jeffrey BG. J Pediatr. 2003;143:S87–95.
Neuringer M, Connor WE, Barstad L, Luck S. Proc Natl Acad Sci. 1986;83:4021–5.
Niu SL, Mitchell DC, Litman BJ. J Biol Chem. 2001;276:42807–11.
Nui SL, Mitchell DC, Lim SY, Wen ZM, Kim HY, Salem N, et al. J Biol Chem. 2004;279:31098–104.
O’Connor DL, Hall R, Adamkin D, Auestad N, Castillo M, Connor WE, et al. J Pediatr. 2001;108:359–71.
Olsen SF, Secher NJ. Br Med J. 2002;324:447–50.
Olsen SF, Hansen HS, Secher NJ, Jensen B, Sandstrom B. Br. J Nutr. 1995;73:397–404.
Salem Jr N, Litman B, Kim HY, Gawrisch K. Lipids. 2001;36:945–59.
Sarkadi-Nagy E, Wijendran V, Diau GY, Chao AC, Hsieh AT, Turpeinen A, et al. Pediatr Res. 2003;54:244–52.
Simopoulos AP, Leaf A, Salem N. Prostaglandins Leukot Essent Fatty Acids. 2000;83:119–21.
Uauy R, Hoffman DR, Birch EE, Birch DG, Jameson DM, Tyson J. J Pediatr. 1994;124:612–20.
Von Hofsten C. J Exp Child Psychol. 1980;30:369–82.
Wijendran V, Bendel RB, Couch SC, Philipson EH, Cheruku S, Lammi-Keefe CJ. Lipids. 2000;35:927–31.
Zigmond MJ, Bloom FE, Landis SC, Roberts JL, Squire LR. Fundamental Neuroscience. San Diego: Academic; 1999.
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Judge, M.P., Lammi-Keefe, C.J., Durham, H. (2011). Infant Visual Acuity and Relationships with Diet and Nutrition. In: Preedy, V., Watson, R., Martin, C. (eds) Handbook of Behavior, Food and Nutrition. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92271-3_5
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