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Lipid Rafts as Regulators of SNARE Activity and Exocytosis

  • Chapter
Molecular Mechanisms of Exocytosis

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

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Abstract

Lipid rafts, cholesterol and sphingolipid rich microdomains of the plasma membrane, have been implicated in the regulation of several intracellular pathways. Interestingly, components of the SNARE membrane fusion machinery associate with raft domains, and recent work suggests that this interaction may play an important role in regulated exocytosis. Here, we review the relationship between rafts and SNAREs, and discuss how rafts might participate in regulated exocytosis.

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  1. Henry Wellcome Laboratory of Cell Biology, Division of Biochemistry and Molecular Biology, Davidson Building, IBLS, University of Glasgow, Glasgow, G12 8QQ, UK

    Christine Salaün & Luke H. Chamberlain

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  1. Christine Salaün
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Salaün, C., Chamberlain, L.H. (2007). Lipid Rafts as Regulators of SNARE Activity and Exocytosis. In: Molecular Mechanisms of Exocytosis. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39961-4_7

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