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Role of Hedgehog and Gli Signalling in Telencephalic Development

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Shh and Gli Signalling and Development

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Studies performed over the last decade have significantly increased our understanding of the role of Hedgehog (Hh) signalling in brain development. Here, we review the various in vitro and in vivo studies demonstrating the importance of Hh signalling for dorsoventral patterning of the telencephalon. The use of conditional knockouts has been particularly helpful in defining the spatial and temporal requirements of Hh signalling during telencephalic development. We also discuss the primary effectors of Hh signalling, the Gli family of transcription factors, and focus on Gli3, which is particularly important for telencephalic development, as reflected in the severe telencephalic phenotype of Gli3 mutant mice. The presence of some dorsoventral patterning in animals lacking both Shh and GH3 implies that, although these molecules are major players in patterning the telencephalon, other patterning factors exist.

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References

  1. Ericson J, Muhr J, Jessell TM et al. Sonic hedgehog: A common signal for ventral patterning along the rostrocaudal axis of the neural tube. Int J Dev Biol 1995; 39(5):809–816.

    PubMed  CAS  Google Scholar 

  2. Lumsden A, Krumlauf R. Patterning the vertebrate neuraxis. Science 1996;274(5290):1109–1115.

    Article  PubMed  CAS  Google Scholar 

  3. Patten I, Placzek M. The role of Sonic hedgehog in neural tube patterning. Cell Mol Life Sci 2000; 57(12):1695–1708.

    Article  PubMed  CAS  Google Scholar 

  4. Echelard Y, Epstein DJ, St-Jacques B et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 1993; 75(7):1417–1430.

    Article  PubMed  CAS  Google Scholar 

  5. Ingham PW, McMahon AP. Hedgehog signaling in animal development: Paradigms and principles. Genes Dev 2001; 15(23):3059–3087.

    Article  PubMed  CAS  Google Scholar 

  6. Lum L, Beachy PA. The Hedgehog response network: Sensors, switches, and routers. Science 2004; 304(5678):1755–1759.

    Article  PubMed  CAS  Google Scholar 

  7. Walterhouse D, Ahmed M, Slusarski D et al. Gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development. Dev Dyn 1993; 196(2):91–102.

    PubMed  CAS  Google Scholar 

  8. Hui CC, Slusarski D, Platt KA et al. Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm-and mesoderm-derived tissues suggests multiple roles during postimplantation development. Dev Biol 1994; 162(2):402–413.

    Article  PubMed  CAS  Google Scholar 

  9. von Mering C, Basler K. Distinct and regulated activities of human Gli proteins in Drosophila. Curr Biol 1999; 9(22):1319–1322.

    Article  Google Scholar 

  10. Aza-Blanc P, Lin HY, Ruiz i Altaba A et al. Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities. Development 2000; 127(19):4293–4301.

    PubMed  Google Scholar 

  11. Yoon JW, Kita Y, Frank DJ et al. Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem 2002; 277(7):5548–5555.

    Article  PubMed  CAS  Google Scholar 

  12. Agren M, Kogerman P, Kleman MI et al. Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site. Gene 2004; 330:101–114.

    Article  PubMed  CAS  Google Scholar 

  13. Dai P, Akimaru H, Tanaka Y et al. Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J Biol Chem 1999; 274(12):8143–8152.

    Article  PubMed  CAS  Google Scholar 

  14. Bigelow RL, Chari NS, Unden AB et al. Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J Biol Chem 2004; 279(2):1197–1205.

    Article  PubMed  CAS  Google Scholar 

  15. Kawai S, Sugiura T. Characterization of human bone morphogenetic protein (BMP)-4 and-7 gene promoters: Activation of BMP promoters by Gli, a sonic hedgehog mediator. Bone 2001; 29(1):54–61.

    Article  PubMed  CAS  Google Scholar 

  16. Sasaki H, Hui C, Nakafuku M et al. A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 1997; 124(7):1313–1322.

    PubMed  CAS  Google Scholar 

  17. Hynes M, Stone DM, Dowd M et al. Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 1997; 19(1):15–26.

    Article  PubMed  CAS  Google Scholar 

  18. Sasaki H, Nishizaki Y, Hui C et al. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 1999; 126(17):3915–3924.

    PubMed  CAS  Google Scholar 

  19. Ruiz i Altaba A. Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. Development 1998; 125(12):2203–2212.

    PubMed  Google Scholar 

  20. Shin SH, Kogerman P, Lindstrom E et al. GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization. Proc Natl Acad Sci USA 1999; 96(6):2880–2884.

    Article  PubMed  CAS  Google Scholar 

  21. Motoyama J, Milenkovic L, Iwama M et al. Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. Dev Biol 2003; 259(1):150–161.

    Article  PubMed  CAS  Google Scholar 

  22. Bai CB, Stephen D, Joyner AL. All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev Cell 2004; 6(1):103–115.

    Article  PubMed  CAS  Google Scholar 

  23. Tyurina OV, Guner B, Popova E et al. Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling. Dev Biol 2005; 277(2):537–556.

    Article  PubMed  CAS  Google Scholar 

  24. Wang B, Fallon JF, Beachy PA. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 2000; 100(4):423–434.

    Article  PubMed  CAS  Google Scholar 

  25. Litingtung Y, Dahn RD, Li Y et al. Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature 2002; 418(6901):979–983.

    Article  PubMed  CAS  Google Scholar 

  26. Bastida MF, Delgado MD, Wang B et al. Levels of Gli3 repressor correlate with Bmp4 expression and apoptosis during limb development. Dev Dyn 2004; 231(1):148–160.

    Article  PubMed  CAS  Google Scholar 

  27. Lee J, Platt KA, Censullo P et al. Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 1997; 124(13):2537–2552.

    PubMed  CAS  Google Scholar 

  28. Marigo V, Johnson RL, Vortkamp A et al. Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev Biol 1996; 180(1):273–283.

    Article  PubMed  CAS  Google Scholar 

  29. Takahashi M, Tamura K, Buscher D et al. The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development. Development 1998; 125(22):4417–4425.

    PubMed  CAS  Google Scholar 

  30. Schweitzer R, Vogan KJ, Tabin CJ. Similar expression and regulation of Gli2 and Gli3 in the chick limb bud. Mech Dev 2000; 98(1–2):171–174.

    Article  PubMed  CAS  Google Scholar 

  31. Buscher D, Bosse B, Heymer J et al. Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech Dev 1997; 62(2):175–182.

    Article  PubMed  CAS  Google Scholar 

  32. Masuya H, Sagai T, Moriwaki K et al. Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouse. Dev Biol 1997; 182(1):42–51.

    Article  PubMed  CAS  Google Scholar 

  33. Corbin JG, Nery S, Fishell G. Telencephalic cells take a tangent: Nonradial migration in the mammalian forebrain. Nat Neurosci 2001; (4 Suppl):1177–1182.

    Article  PubMed  CAS  Google Scholar 

  34. Ericson J, Muhr J, Placzek M et al. Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube. Cell 1995; 81(5):747–756.

    Article  PubMed  CAS  Google Scholar 

  35. Roessler E, Belloni E, Gaudenz K et al. Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nat Genet 1996; 14(3):357–360.

    Article  PubMed  CAS  Google Scholar 

  36. Belloni E, Muenke M, Roessler E et al. Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nat Genet 1996; 14(3):353–356.

    Article  PubMed  CAS  Google Scholar 

  37. Chiang C, Litingtung Y, Lee E et al. Cydopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 1996; 383(6599):407–413.

    Article  PubMed  CAS  Google Scholar 

  38. Pabst O, Herbrand H, Takuma N et al. NKX2 gene expression in neuroectoderm but not in mesendodermally derived structures depends on sonic hedgehog in mouse embryos. Dev Genes Evol 2000; 210(1):47–50.

    Article  PubMed  CAS  Google Scholar 

  39. Rallu M, Machold R, Gaiano N et al. Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling. Development 2002; 129(21):4963–4974.

    PubMed  CAS  Google Scholar 

  40. Corbin JG, Rutlin M, Gaiano N et al. Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning. Development 2003; 130(20):4895–4906.

    Article  PubMed  CAS  Google Scholar 

  41. Aoto K, Nishimura T, Eto K et al. Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud. Dev Biol 2002; 251(2):320–332.

    Article  PubMed  CAS  Google Scholar 

  42. Ohkubo Y, Chiang C, Rubenstein JL. Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles. Neuroscience 2002; 111(1):1–17.

    Article  PubMed  CAS  Google Scholar 

  43. Zhang XM, Ramalho-Santos M, McMahon AP. Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. Cell 2001; 105(6):781–792.

    Article  PubMed  CAS  Google Scholar 

  44. Pierani A, Brenner-Morton S, Chiang C et al. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Cell 1999; 97(7):903–915.

    Article  PubMed  CAS  Google Scholar 

  45. Novitch BG, Wichterle H, Jessell TM et al. A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification. Neuron 2003; 40(1):81–95.

    Article  PubMed  CAS  Google Scholar 

  46. LaMantia AS, Colbert MC, Linney E. Retinoic acid induction and regional differentiation prefigure olfactory pathway formation in the mammalian forebrain. Neuron 1993; 10(6):1035–1048.

    Article  PubMed  CAS  Google Scholar 

  47. Toresson H, Mata de Urquiza A, Fagerstrom C et al. Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation. Development 1999; 126(6):1317–1326.

    PubMed  CAS  Google Scholar 

  48. Schneider RA, Hu D, Rubenstein JL et al. Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH. Development 2001; 128(14):2755–2767.

    PubMed  CAS  Google Scholar 

  49. Rubenstein JL, Shimamura K, Martinez S et al. Regionalization of the prosencephalic neural plate. Annu Rev Neurosci 1998; 21:445–477.

    Article  PubMed  CAS  Google Scholar 

  50. Gunhaga L, Jessell TM, Edlund T. Sonic hedgehog signaling at gastrula stages specifies ventral telencephalic cells in the chick embryo. Development 2000; 127(15):3283–3293.

    PubMed  CAS  Google Scholar 

  51. Epstein DJ, McMahon AP, Joyner AL. Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and-independent mechanisms. Development 1999; 126(2):281–292.

    PubMed  CAS  Google Scholar 

  52. Kiecker C, Niehrs C. The role of prechordal mesendoderm in neural patterning. Curr Opin Neurobiol 2001; 11(1):27–33.

    Article  PubMed  CAS  Google Scholar 

  53. Shimamura K, Rubenstein JL. Inductive interactions direct early regionalization of the mouse forebrain. Development 1997; 124(14):2709–2718.

    PubMed  CAS  Google Scholar 

  54. Pera EM, Kessel M. Patterning of the chick forebrain anlage by the prechordal plate. Development 1997; 124(20):4153–4162.

    PubMed  CAS  Google Scholar 

  55. Dale JK, Vesque C, Lints TJ et al. Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm. Cell 1997; 90(2):257–269.

    Article  PubMed  CAS  Google Scholar 

  56. Briscoe J, Chen Y, Jessell TM et al. A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube. Mol Cell 2001; 7(6):1279–1291.

    Article  PubMed  CAS  Google Scholar 

  57. Lewis PM, Dunn MP, McMahon JA et al. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptcl. Cell 2001; 105(5):599–612.

    Article  PubMed  CAS  Google Scholar 

  58. Zeng X, Goetz JA, Suber LM et al. A freely diffusible form of Sonic hedgehog mediates long-range signalling. Nature 2001; 411(6838):716–720.

    Article  PubMed  CAS  Google Scholar 

  59. Nery S, Wichterle H, Fishell G. Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain. Development 2001; 128(4):527–540.

    PubMed  CAS  Google Scholar 

  60. Platt KA, Michaud J, Joyner AL. Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice. Mech Dev 1997; 62(2):121–135.

    Article  PubMed  CAS  Google Scholar 

  61. Kohtz JD, Baker DP, Corte G et al. Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog. Development 1998; 125(24):5079–5089.

    PubMed  CAS  Google Scholar 

  62. Machold R, Hayashi S, Rutlin M et al. Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 2003; 39(6):937–950.

    Article  PubMed  CAS  Google Scholar 

  63. Palma V, Lim DA, Dahmane N et al. Sonic hedgehog controls stem cell behavior in the postnatal and adult brain. Development 2005; 132(2):335–344.

    Article  PubMed  CAS  Google Scholar 

  64. Fuccillo M, Rallu M, McMahon AP et al. Temporal requirement for hedgehog signaling in ventral telencephalic patterning. Development 2004; 131(20):5031–5040.

    Article  PubMed  CAS  Google Scholar 

  65. Wijgerde M, McMahon JA, Rule M et al. A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev 2002; 16(22):2849–2864.

    Article  PubMed  CAS  Google Scholar 

  66. Dahmane N, Sanchez P, Gitton Y et al. The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development 2001; 128(24):5201–5212.

    PubMed  CAS  Google Scholar 

  67. Graham A, Koentges G, Lumsden A. Neural crest apoptosis and the establishment of craniofacial pattern: An honorable death. Mol Cell Neurosci 1996; 8(2–3):76–83.

    Article  CAS  Google Scholar 

  68. Merino R, Ganan Y, Macias D et al. Bone morphogenetic proteins regulate interdigital cell death in the avian embryo. Ann NY Acad Sci 1999; 887:120–132.

    Article  PubMed  CAS  Google Scholar 

  69. Golden JA, Bracilovic A, McFadden KA et al. Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly. Proc Natl Acad Sci USA 1999; 96(5):2439–2444.

    Article  PubMed  CAS  Google Scholar 

  70. Furuta Y, Piston DW, Hogan BL. Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development 1997; 124(11):2203–2212.

    PubMed  CAS  Google Scholar 

  71. Mabie PC, Mehler MF, Kessler JA. Multiple roles of bone morphogenetic protein signaling in the regulation of cortical cell number and phenotype. J Neurosci 1999; 19(16):7077–7088.

    PubMed  CAS  Google Scholar 

  72. Israsena N, Kessler JA. Msx2 and p21(CIPl/WAFl) mediate the proapoptotic effects of bone morphogenetic protein-4 on ventricular zone progenitor cells. J Neurosci Res 2002; 69(6):803–809.

    Article  PubMed  CAS  Google Scholar 

  73. Thibert C, Teillet MA, Lapointe F et al. Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog. Science 2003; 301(5634):843–846.

    Article  PubMed  CAS  Google Scholar 

  74. Gaiano N, Kohtz JD, Turnbull DH et al. A method for rapid gain-of-function studies in the mouse embryonic nervous system. Nat Neurosci 1999; 2(9):812–819.

    Article  PubMed  CAS  Google Scholar 

  75. Barnes EA, Kong M, Ollendorff V et al. Patchedl interacts with cyclin B1 to regulate cell cycle progression. EMBO J 2001; 20(9):2214–2223.

    Article  PubMed  CAS  Google Scholar 

  76. Lu QR, Yuk D, Alberta JA et al. Sonic hedgehog—regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron 2000; 25(2):317–329.

    Article  PubMed  CAS  Google Scholar 

  77. Tekki-Kessaris N, Woodruff R, Hall AC et al. Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. Development 2001; 128(13):2545–2554.

    PubMed  CAS  Google Scholar 

  78. Spassky N, Heydon K, Mangatal A et al. Sonic hedgehog-dependent emergence of oligodendrocytes in the telencephalon: Evidence for a source of oligodendrocytes in the olfactory bulb that is independent of PDGFRalpha signaling. Development 2001; 128(24):4993–5004.

    PubMed  CAS  Google Scholar 

  79. Gulacsi A, Lillien L. Sonic hedgehog and bone morphogenetic protein regulate interneuron development from dorsal telencephalic progenitors in vitro. J Neurosci 2003; 23(30):9862–9872.

    PubMed  CAS  Google Scholar 

  80. Matise MP, Epstein DJ, Park HL et al. Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 1998; 125(15):2759–2770.

    PubMed  CAS  Google Scholar 

  81. Park HL, Bai C, Platt KA et al. Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development 2000; 127(8):1593–1605.

    PubMed  CAS  Google Scholar 

  82. Ding Q, Motoyama J, Gasca S et al. Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 1998; 125(14):2533–2543.

    PubMed  CAS  Google Scholar 

  83. Palma V, Ruiz i Altaba A. Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex. Development 2004; 131(2):337–345.

    Article  PubMed  CAS  Google Scholar 

  84. Shinozaki K, Yoshida M, Nakamura M et al. Emx1 and Emx2 cooperate in initial phase of archipallium development. Mech Dev 2004; 121(5):475–489.

    Article  PubMed  CAS  Google Scholar 

  85. Schimmang T, Lemaistre M, Vortkamp A et al. Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt). Development 1992; 116(3):799–804.

    PubMed  CAS  Google Scholar 

  86. Hui CC, Joyner AL. A mouse model of greig cephalopolysyndactyly syndrome: The extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat Genet 1993; 3(3):241–246.

    Article  PubMed  CAS  Google Scholar 

  87. Buscher D, Grotewold L, Ruther U. The XtJ allele generates a Gli3 fusion transcript. Mamm Genome 1998; 9(8):676–678.

    Article  PubMed  CAS  Google Scholar 

  88. Maynard TM, Jain MD, Balmer CW et al. High-resolution mapping of the Gli3 mutation extra-toes reveals a 51.5-kb deletion. Mamm Genome 2002; 13(1):58–61.

    Article  PubMed  CAS  Google Scholar 

  89. Franz T. Extra-toes (Xt) homozygous mutant mice demonstrate a role for the Gli-3 gene in the development of the forebrain. Acta Anat (Basel) 1994; 150(1):38–44.

    Article  PubMed  CAS  Google Scholar 

  90. Theil T, Alvarez-Bolado G, Walter A et al. Gli3 is required for Emx gene expression during dorsal telencephalon development. Development 1999; 126(16):3561–3571.

    PubMed  CAS  Google Scholar 

  91. Grove EA, Tole S, Limon J et al. The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. Development 1998; 125(12):2315–2325.

    PubMed  CAS  Google Scholar 

  92. Tole S, Ragsdale CW, Grove EA. Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J). Dev Biol 2000; 217(2):254–265.

    Article  PubMed  CAS  Google Scholar 

  93. Theil T, Aydin S, Koch S et al. Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon. Development 2002; 129(13):3045–3054.

    PubMed  CAS  Google Scholar 

  94. Kuschel S, Ruther U, Theil T. A disrupted balance between Bmp/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalon. Dev Biol 2003; 260(2):484–495.

    Article  PubMed  CAS  Google Scholar 

  95. Rubenstein JL, Beachy PA. Patterning of the embryonic forebrain. Curr Opin Neurobiol 1998; 8(1):18–26.

    Article  PubMed  CAS  Google Scholar 

  96. Monuki ES, Walsh CA. Mechanisms of cerebral cortical patterning in mice and humans. Nat Neurosci 2001; (4 Suppl):1199–1206.

    Article  PubMed  CAS  Google Scholar 

  97. Zaki PA, Quinn JC, Price DJ. Mouse models of telencephalic development. Curr Opin Genet Dev 2003; 13(4):423–437.

    Article  PubMed  CAS  Google Scholar 

  98. Roth KA, D’Sa C. Apoptosis and brain development. Ment Retard Dev Disabil Res Rev 2001; 7(4):261–266.

    Article  PubMed  CAS  Google Scholar 

  99. te Welscher P, Zuniga A, Kuijper S et al. Progression of vertebrate limb development through SHH-mediated counteraction of GLI3. Science 2002; 298(5594):827–830.

    Article  CAS  Google Scholar 

  100. Litingtung Y, Chiang C. Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Nat Neurosci 2000; 3(10):979–985.

    Article  PubMed  CAS  Google Scholar 

  101. Bose J, Grotewold L, Ruther U. Pallister-Hall syndrome phenotype in mice mutant for Gli3. Hum Mol Genet 2002; 11(9):1129–1135.

    Article  PubMed  CAS  Google Scholar 

  102. Persson M, Stamataki D, te Welscher P et al. Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev 2002; 16(22):2865–2878.

    Article  PubMed  CAS  Google Scholar 

  103. Krishnan V, Pereira FA, Qiu Y et al. Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase. Science 1997; 278(5345):1947–1950.

    Article  PubMed  CAS  Google Scholar 

  104. Tripodi M, Filosa A, Armentano M et al. The COUP-TF nuclear receptors regulate cell migration in the mammalian basal forebrain. Development 2004; 131(24):6119–6129.

    Article  PubMed  CAS  Google Scholar 

  105. Liu F, Massague J, Ruiz i Altaba A. Carboxy-terminally truncated Gli3 proteins associate with Smads. Nat Genet 1998; 20(4):325–326.

    Article  PubMed  CAS  Google Scholar 

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  1. Genes and Development IDG, Section of Biomedical Sciences, University of Edinburgh, Hugh Robson Building George Square, Edinburgh, EH8 9XD, UK

    Paulette A. Zaki, Ben Martynoga & David J. Price

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  1. Paulette A. Zaki
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  2. Ben Martynoga
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Zaki, P.A., Martynoga, B., Price, D.J. (2006). Role of Hedgehog and Gli Signalling in Telencephalic Development. In: Shh and Gli Signalling and Development. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39957-7_3

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