Shh and Gli Signalling in Development

1. Front Matter

   Pages i-x

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2. Introduction

   • Carolyn E. Fisher, Sarah E.M. Howie

   Pages 1-11

3. Sonic Hedgehog Signalling in Dorsal Midline and Neural Development

   • Silvia L. López, Andrés E. Carrasco

   Pages 12-22

4. Role of Hedgehog and Gli Signalling in Telencephalic Development

   • Paulette A. Zaki, Ben Martynoga, David J. Price

   Pages 23-35

5. Role of Shh and Gli Signalling in Oligodendroglial Development

   • Min Tan, Yingchuan Qi, Mengsheng Qiu

   Pages 36-43

6. The Role of Sonic Hedgehog Signalling in Craniofacial Development

   • Dwight Cordero, Minal Tapadia, Jill A. Helms

   Pages 44-57

7. Multiple Roles for Hedgehog Signalling in Zebrafish Eye Development

   • Deborah L. Stenkamp

   Pages 58-68

8. Sonic Hedgehog Signalling during Tooth Morphogenesis

   • Martyn T. Cobourne, Isabelle Miletich, Paul T. Sharpe

   Pages 69-78

9. Limb Pattern Formation

   • Aimée Zuniga, Antonella Galli

   Pages 79-92

10. Sonic Hedgehog Signalling in the Developing and Regenerating Fins of Zebrafish

    • Fabien Avaron, Amanda Smith, Marie-Andrée Akimenko

    Pages 93-106

11. Hedgehog Signalling in T Lymphocyte Development

    • Susan Outram, Ariadne L. Hager-Theodorides, Tessa Crompton

    Pages 107-115

12. Hedgehog Signalling in Prostate Morphogenesis

    • Marilyn L. G. Lamm, Wade Bushman

    Pages 116-124

13. Sonic Hedgehog Signalling in Visceral Organ Development

    • Huimin Zhang, Ying Litingtung, Chin Chiang

    Pages 125-136

14. Shh/Gli Signalling during Murine Lung Development

    • Martin Rutter, Martin Post

    Pages 137-146

15. New Perspectives in Shh Signalling?

    • Carolyn E. Fisher

    Pages 147-154

16. Back Matter

    Pages 155-158

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he hedgehog signalling pathway is highly conserved and seen in organisms ranging from Drosophila to humans. This pathway is Tcritical in determining cell fate decisions in a variety of different cell types. There are several vertebrate analogues of the Drosophila hedgehog protein of which the most widely studied is Sonic hedgehog (Shh). Shh signalling classically involves the Gli family of zinc-fmger transcription factors. The Shh signalling pathway is well characterised in the develop­ ment of a number of vertebrate organ systems. It could indeed be argued that the Shh and Gli signalling may well be involved at some stage in the development of all the major organ systems in vertebrates. This volume rep­ resents a concerted drive to bring together *state of the art' reviews by lead­ ing experts in the field of Shh and Gli signalling in development from all over the world. The chapters span vertebrate organisms from zebrafish to humans and cover development of the multiple organ systems in which the Shh signalling pathway is crucial for normal development. There are chap­ ters on the development of the central nervous system, skeletal struc­ tures, visceral organs, prostate, lung, immune system and the structures of the human face. The authors themselves span three major continents and multiple nationalities which admirably illustrates the worldwide nature of the science.

• Invertebrate
• Vertebrate
• cell
• development
• invertebrates
• morphogenesis
• mouse
• transcription
• vertebrates

• Immunobiology Group MRC/UoE Centre for Inflammation Research, The Queen’s Medical Research Institute, Edinburgh, UK

  Carolyn E. Fisher, Sarah E. M. Howie

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