Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ablamunits, V., Quintana, F., Reshef, T., et al. (1999) Acceleration of autoimmune diabetes by cyclophosphamide is associated with an enhanced IFN-gamma secretion pathway. J. Autoimmun. 13:383–392.
Almawi, W. Y., Melemedjian, O. K., Rieder, M. J. (1999) An alternate mechanism of glucocorticoid anti-proliferative effect: promotion of a Th2 cytokine-secreting profile. Clin. Transplant. 13:365–374.
Banerjee, S., Webber, C., Poole, A. R. (1992) The induction of arthritis in mice by the cartilage proteoglycan aggrecan: roles of CD4+ and CD8+ T cells. Cell. Immunol. 144:347–357.
Barrett, S. P., Toh, B. H., Alderuccio, F., et al. (1995) Organ-specific autoimmunity induced by adult thymectomy and cyclophosphamide-induced lymphopenia. Eur. J. Immunol. 25:238–244.
Bessis, N., Boissier, M. C., Ferrara, P., et al. (1996) Attenuation of collagen-induced arthritis in mice by treatment with vector cells engineered to secrete interleukin-13. Eur. J. Immunol. 26:2399–2403.
Breedveld, F. C., Dynesius-Trentham, R., de Sousa, M., Trentham, D. E. (1989) Collagen arthritis in the rat is initiated by CD4+ T cells and can be amplified by iron. Cell. Immunol. 121:1–12.
Bruneau, J. M., Yea, C. M., Spinella-Jaegle, S., et al. (1998) Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide. Biochem. J. 336:299–303.
Calin, A., Elswood, J., Klouda, P. T. (1989) Destructive arthritis, rheumatoid factor, and HLA-DR4: susceptibility versus severity, a case-control study. Arthritis Rheum. 32:1221–1225.
Constantin, A., Loubet-Lescoulie, P., Lambert, N., et al. (1998) Antiinflammatory and immunoregulatory action of methotrexate in the treatment of rheumatoid arthritis: evidence of increased interleukin-4 and interleukin-10 gene expression demonstrated in vitro by competitive reverse transcriptase-polymerase chain reaction. Arthritis Rheum. 41:48–57.
De Groot, K., Gross, W. L. (1998) Wegener’s granulomatosis: disease course, assessment of activity and extent and treatment. Lupus 7:285–291.
Dimitrova, P., Skapenko, A., Herrmann, M. L., et al. (2002) Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiation. J. Immunol. 169:3392–3399.
Emmrich, F., Schulze-Koops, H., Burmester, G. (1994) Anti-CD4 and other antibodies to cell surface antigens for therapy. In: Immunopharmacology of Joints and Connective Tissue. London, Academic Press, pp 87–117.
Firestein, G. S. (2003) Evolving concepts of rheumatoid arthritis. Nature 423:356–361.
Fontenot, J. D., Gavin, M. A., Rudensky, A. Y. (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4:330–336.
Genovese, M. C., Becker, J. C., Schiff, M., et al. (2005) Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition. N. Engl. J. Med. 353:1114–1123.
Gleeson, P. A., Toh, B. H., van Driel, I. R. (1996) Organ-specific autoimmunity induced by lymphopenia. Immunol. Rev. 149:97–125.
Gottlieb, A. B. (2006) Alefacept for psoriasis and psoriatic arthritis. Ann. Rheum. Dis. 64:58–60.
Hepburn, T. W., Totoritis, M. C., Davis, C. B. (2003) Antibody-mediated stripping of CD4 from lymphocyte cell surface in patients with rheumatoid arthritis. Rheumatology (Oxford) 42:54–61.
Joosten, L. A., Lubberts, E., Helsen, M. M., et al. (1999) Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis. Arthritis Res. 1:81–91.
Kang, B. Y., Chung, S. W., Im, S. Y., et al. (1999) Sulfasalazine prevents T-helper 1 immune response by suppressing interleukin-12 production in macrophages. Immunology 98:98–103.
Kavanaugh, A. F., Davis, L. S., Nichols, L. A., et al. (1994) Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule 1. Arthritis Rheum. 37:992–999.
Kavanaugh, A. F., Schulze-Koops, H., Davis, L. S., Lipsky, P. E. (1997). Repeat treatment of rheumatoid arthritis patients with a murine anti-intercellular adhesion molecule 1 monoclonal antibody. Arthritis Rheum. 40:849–853.
Kojima, A., Prehn, R. T. (1981) Genetic susceptibility to post-thymectomy autoimmune diseases in mice. Immunogenetics 14:15–27.
Kremer, J. M., Westhovens, R., Leon, M., et al. (2003) Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N. Engl. J. Med. 349:1907–1915.
Kremer, J. M., Dougados, M., Emery, P., et al. (2005) Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial. Arthritis Rheum. 52:2263–2271.
Leung, B. P., Sattar, N., Crilly, A., et al. (2003) A novel anti-inflammatory role for simvastatin in inflammatory arthritis. J. Immunol. 170:1524–1530.
Maksymowych, W. P., Blackburn, W. D., Jr., Tami, J. A., Shanahan, W. R., Jr. (2002) A randomized, placebo controlled trial of an antisense oligodeoxynucleotide to intercellular adhesion molecule-1 in the treatment of severe rheumatoid arthritis. J. Rheumatol. 29:447–453.
Miltenburg, A. M., van Laar, J. M., de Kuiper, R., et al. (1992) T cells cloned from human rheumatoid synovial membrane functionally represent the Th1 subset. Scand. J. Immunol. 35:603–610.
Mizoguchi, A., Mizoguchi, E., Smith, R. N., et al. (1997) Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice. J. Exp. Med. 186:1749–1756.
Mombaerts, P., Mizoguchi, E., Grusby, M. J., et al. (1993) Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 75:274–282.
Moreland, L. W., Alten, R., Van den Bosch, F., et al. (2002) Costimulatory blockade in patients with rheumatoid arthritis: a pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y eighty-five days after the first infusion. Arthritis Rheum. 46:1470–1479.
Morinobu, A., Wang, Z., Kumagai, S. (2000) Bucillamine suppresses human Th1 cell development by a hydrogen peroxide-independent mechanism. J. Rheumatol. 27:851–858.
Patel, S., Veale, D., FitzGerald, O., McHugh, N. J. (2001) Psoriatic arthritis—emerging concepts. Rheumatology 40:243–246.
Sadlack, B., Merz, H., Schorle, H., et al. (1993) Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253–261.
Sakaguchi, N., Miyai, K., Sakaguchi, S. (1994a) Ionizing radiation and autoimmunity. Induction of autoimmune disease in mice by high dose fractionated total lymphoid irradiation and its prevention by inoculating normal T cells. J. Immunol. 152:2586–2595.
Sakaguchi, S., Ermak, T. H., Toda, M., et al. (1994b) Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression. J. Immunol. 152:1471–1484.
Sakaguchi, S., Sakaguchi, N. (1989) Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease. J. Immunol. 142:471–480.
Sakaguchi, S., Sakaguchi, N., Asano, M., et al. (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151–1164.
Schulze-Koops, H. (2004). Lymphopenia and autoimmune diseases. Arthritis Res. Ther. 6:178–180.
Schulze-Koops, H., Kalden, J. R. (2003) Targeting T Cells in rheumatic diseases. In: Smolen, J. S., Lipsky, P. E. (eds) Biological Therapy in Rheumatology. London, Martin Dunitz, pp 3–24.
Schulze-Koops, H., Lipsky, P. E. (2000) Anti-CD4 monoclonal antibody therapy in human autoimmune diseases. Curr. Dir. Autoimmun. 2:24–49.
Schulze-Koops, H., Lipsky, P. E. (2004) T cells in the pathogenesis of rheumatoid arthritis. In: Clair, W. W., Pisetsky, D. S., Haynes A. (eds) Rheumatoid Arthritis. Philadelphia, Lippincott Williams & Wilkins, pp 184–196.
Schulze-Koops, H., Lipsky, P. E., Kavanaugh, A. F., Davis, L. S. (1995). Elevated Th1- or Th0-like cytokine mRNA in peripheral circulation of patients with rheumatoid arthritis: modulation by treatment with anti-ICAM-1 correlates with clinical benefit. J. Immunol. 155:5029–5037.
Simon, A. K., Seipelt, E., Sieper, J. (1994) Divergent T-cell cytokine patterns in inflammatory arthritis. Proc. Natl. Acad. Sci. USA 91:8562–8566.
Skapenko, A., Wendler, J., Lipsky, P. E., et al. (1999) Altered memory T cell differentiation in patients with early rheumatoid arthritis. J. Immunol. 163:491–499.
Skapenko, A., Lipsky, P. E., Kraetsch, H. G., et al. (2001) Antigen-independent Th2 cell differentiation by stimulation of CD28: regulation via IL-4 gene expression and mitogen-activated protein kinase activation. J. Immunol. 166:4283–4292.
Utset, T. O., Auger, J. A., Peace, D., et al. (2002) Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial. J. Rheumatol. 29:1907–1913.
Wildin, R. S., Smyk-Pearson, S., Filipovich, A. H. (2002) Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J. Med. Genet. 39:537–545.
Winchester, R. (1994) The molecular basis of susceptibility to rheumatoid arthritis. Adv. Immunol. 56:389–466.
Yacyshyn, B. W., Chey, W., Salzberg, G. B., et al. (2000) Double-blinded, randomized, placebo-controlled trial of the remission inducing and steroid sparing properties of two schedules of ISIS 2302 (ICAM-1 antisense) in active, steroid-dependent Crohn’s disease. Gastroenterology 118:S2:2977.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Schulze-Koops, H., Lipsky, P.E. (2007). T Cell-Targeted Therapy for Rheumatoid Arthritis. In: Zhang, J. (eds) Immune Regulation and Immunotherapy in Autoimmune Disease. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-36003-4_18
Download citation
DOI: https://doi.org/10.1007/978-0-387-36003-4_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-36002-7
Online ISBN: 978-0-387-36003-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)