Immune Regulation and Immunotherapy in Autoimmune Disease

1. Front Matter

   Pages i-xvi

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2. Immune Regulation and Autoimmune Disease

   1. Front Matter

      Pages 1-1

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   2. Autoimmune Response and Immune Tolerance

      • Ana C. Anderson, Vijay K. Kuchroo

      Pages 3-19

   3. Priming Regulatory T Cells and Antigen-Specific Suppression of Autoimmune Disease

      • Trevor R. F. Smith, Xiaolei Tang, Vipin Kumar

      Pages 20-35

   4. Peripheral T Cell Regulation and Autoimmunity

      • Hong Jiang, Leonard Chess

      Pages 36-55

   5. Anti-Ergotypic Regulation of the Immune Response

      • Francisco J. Quintana, Irun R. Cohen

      Pages 56-65

   6. How B Cells Contribute to Multiple Sclerosis Pathology

      • Kevin C. O'Connor, Sunil V. Cherry, David A. Hafler

      Pages 66-86

   7. Molecular Basis for Induction of Tolerance in Type I Diabetes

      • Sophie Candon, Lucienne Chatenoud, Jean-FranÇois Bach

      Pages 87-120

   8. Co-stimulation Regulation of Immune Tolerance and Autoimmunity

      • Chen Dong, Roza Nurieva, Natalia Martin-Orozco

      Pages 121-138

   9. Invariant NKT Cells and Immune Regulation in Multiple Sclerosis

      • Takashi Yamamura

      Pages 139-151

   10. CD4+CD25+ Regulatory T Cells in Autoimmune Disease

       • Adam P. Kohm, Stephen D. Miller

       Pages 152-170

   11. Immunopathogenesis of Multiple Sclerosis: Overview

       • Til Menge, Bernhard Hemmer, Stefan Nessler, Dun Zhou, Bernd C. Kieseier, Hans-Peter Hartung

       Pages 171-187

   12. Viral Infection and Multiple Sclerosis

       • Elizabeth L. Williams, Steven Jacobson

       Pages 188-213

   13. Multiple Sclerosis Pathology During Early and Late Disease Phases: Pathogenic and Clinical Relevance

       • Claudia F. Lucchinetti

       Pages 214-264

   14. CD8+ T Cells in Multiple Sclerosis

       • Manuel A. Friese, Lars Fugger

       Pages 265-285

3. Novel Immunotherapeutic Strategies and Emerging Treatments

   1. Front Matter

      Pages 288-288

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   2. Review of Novel Immunotherapeutic Strategies for MS

      • Heinz Wiendl, Reinhard Hohlfeld

      Pages 289-338

   3. T Cell Vaccination in Autoimmune Disease

      • Sheri M. Skinner, Ying C. Q. Zang, Jian Hong, Jingwu Z. Zhang

      Pages 339-368

   4. Trivalent T Cell Receptor Peptide Vaccine for Treatment of Multiple Sclerosis Targets Predominant V Genes Widely Implicated in Autoimmune Diseases and Allergy

      • Arthur A. Vandenbark, Nicole E. Culbertson

      Pages 369-408

   5. Nonmyeloablative Stem Cell Transplantation for Multiple Sclerosis

      • Richard K. Burt, Yvonne Loh, Larissa Verda

      Pages 409-424

This book critically reviews both clinical and immunological aspects of auto- mune disease with a strong emphasis on multiple sclerosis (MS). Research in MS is one of the fastest-developing areas in modern medicine. It employs some of the newest concepts in autoimmune mechanisms and an array of new treatments that would have been considered science fiction only two decades ago. It is an area in which research findings are being actively translated into treatment strategies. Advances in this area have both clinical and scientific implications for other autoimmune conditions that share many similarities with MS. The book, which comprises 24 chapters contributed by experts and thought leaders in the field, is designed to provide new insights into two arenas: our current understanding of autoimmune mechanisms and immune regulation and the latest developments in immunotherapy. This book is intended for both researchers and clinicians. Its purpose is not only to provide a comprehensive review on the recent advances in the two arenas m- tioned above but also to reflect the current opinions or concepts that influence our thinking about the disease mechanisms and our way of treating MS patients. Many of these issues have emerged from recent studies and are somewhat contradictory to traditional thinking. For example, recent studies have indicated that MS is more heterogeneous in many aspects than traditionally thought. Pathologically, in ad- tion to demyelination and inflammation, there is axonal loss or damage detectable in the central nervous system (CNS) lesions.

• Antigen
• Transplantation
• autoimmune disease
• autoimmunity
• infection
• vaccine
• viral infection
• infectious diseases

• Shanghai JiaoTong University School of Medicine, Shanghai, China

  Jingwu Zhang

• Baylor College of Medicine, Houston, USA

  Jingwu Zhang

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