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Stem Cell Interaction with Topography

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Biomaterials as Stem Cell Niche

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 2))

Abstract

The growth and differentiation of stem cells are regulated by biochemical and biophysical cues in the extracellular microenvironment. Increasing evidences have shown that substrate topography, one of the biophysical properties of the microenvironment, can affect stem cell fate, such as the maintenance of embryonic stem cells and the differentiation of adult and embryonic stem cells. The underlying mechanism of how topography influences stem cells remains unknown. Nevertheless, the advancement in technology has enabled the fabrication of synthetic topography with different materials, chemistries, geometries and sizes, allowing systematic studies of the underlying mechanism. Recent studies show that the topography-induced stem cells response can be a result of mechanotransduction via cellular components such as intergrins, focal adhesion and cytoskeleton organization.

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Authors and Affiliations

  1. Division of Bioengineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117576, Singapore

    Benjamin K. K. Teo, Soneela Ankam & Evelyn K. F. Yim

  2. Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, Singapore, 117597, Singapore

    Evelyn K. F. Yim

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  1. Benjamin K. K. Teo
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  2. Soneela Ankam
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Correspondence to Evelyn K. F. Yim .

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  1. Cockrell School of Engineering, Dept. Biomedical Engineering, University of Texas, Austin, University Station 1, Austin, 78712, Texas, USA

    Krishnendu Roy

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Teo, B.K.K., Ankam, S., Yim, E.K.F. (2010). Stem Cell Interaction with Topography. In: Roy, K. (eds) Biomaterials as Stem Cell Niche. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2010_4

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