Abstract
Serotonin plays an important role in both male and female sexual behaviour. In general, reduction of 5-HT function facilitates, whereas enhancement inhibits sexual behaviour. Most fundamental research on the involvement of 5-HT in sex has been performed in rats. Selective serotonin reuptake inhibitors (SSRIs) have comparable effects on male and female sexual behaviour in rats; they inhibit it but only after chronic administration. Activation of the 5-HT1A receptor facilitates sexual behaviour in male rats but inhibits sexual behaviour in female rats, suggesting a differential role for 5-HT1A receptors in male and female rats. Research on sexual behaviour in rats with null mutations in the serotonin transporter (SERT) indicated also a differential role for 5-HT1A receptors in male and female sexual behaviour. Evidence exists that different pools of 5-HT1A receptors have differential roles in various parts of the cascade of sexual events occurring during sexual interactions. Roles for other 5-HT receptors are less well defined although 5-HT1B, 5-HT2A/B and 5-HT7 receptors seem to be involved. Identification of putative differential or comparable roles in female and male sexual activities requires more research.
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References
Ahlenius S, Larsson K (1990) In: Rodgers RJ, Cooper SJ (eds) 5-HT1A agonists, 5-HT3 antagonists and benzodiazepines: their comparative behavioural pharmacology. Wiley, Chichester, pp 281–301
Ahlenius S, Larsson K (1998) Evidence for an involvement of 5-HT1B receptors in the inhibition of male rat ejaculatory behaviour produced by 5-HTP. Psychopharmacology 137:374–382
Ahlenius S, Larsson K (1999) Synergistic actions of the 5-HT1A antagonist WAY-100635 and citalopram on male rat ejaculatory behaviour. Eur J Pharmacol 379:1–6
Ahlenius S, Larsson K, Svensson L (1980) Further evidence for an inhibitory role of central 5-HT in male rat sexual behaviour. Psychopharmacology 68:217–220
Ahlenius S, Fernandez-Guasti A, Hjorth S, Larsson K (1986) Suppression of lordosis behaviour by the putative 5-HT receptor agonist 8-OH-DPAT in the rat. Eur J Pharmacol 124:361–363
Albinsson A, Andersson G, Andersson K, VegaMatuszczyk J, Larsson K (1996) The effects of lesions in the mesencephalic raphe systems on male rat sexual behaviour and locomotor activity. Behav Brain Res 80:57–63
Andersson G, Larsson K (1994) Effects of FG-5893, a new compound with 5-HT1A receptor agonistic and 5-HT2 antagonistic properties, on male-rat sexual-behaviour. Eur J Pharmacol 255:131–137
Argiolas A (1999) Neuropeptides and sexual behaviour. Neurosci Biobehav Rev 23:1127–1142
Balon R (2006) SSRI-associated sexual dysfunction. Am J psychiatry 163:1504–1509
Barfield RJ, Sachs BD (1968) Sexual behaviour: stimulation by painful electrical shock to skin in male rats. Science 161:392–395
Beach FA (1942) Comparison of copulatory behaviour of male rats raised in isolation, cohabitation, and segregation. J Genet Psychol 60:3–13
Beach FA (1948) Hormones and behaviour. Hoeber Harber, New York
Bitran D, Hull EM (1987) Pharmacological analysis of male rat sexual behaviour. Neurosci Biobehav Rev 11:365–389
Cantor J, Binik I, Pfaus JG (1999) Chronic fluoxetine inhibits sexual behaviour in the male rat: reversal with oxytocin. Psychopharmacology 144:355–362
Chan JSW, Waldinger MD, Olivier B, Oosting RS (2010) Drug-induced sexual dysfunction in rats. Curr protoc Neurosci 53:9.34.1–9.34.11
Chan JSW, Snoeren EMS, Cuppen E, Waldinger MD, Olivier B, Oosting RS (2011) The serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout rats. J Sex Medicine 8:97–108
Cyranowski JM, Bromberger J, Youk A, Matthews K, Kravitz HM, Powell LH (2004) Lifetime depression history and sexual function in women at midlife. Arch Sex Behav 33:539–548
De Jong TR, Pattij T, Veening JG, Dederen PFJ, Waldinger MD, Cools AR, Olivier B (2005a) Citalopram combined with WAY100635 inhibits ejaculation and ejaculation-related Fos immunoreactivity. Eur J Pharmacol 509:49–59
De Jong TR, Pattij T, Veening JG, Waldinger MD, Cools AR, Olivier B (2005b) Effects of chronic selective serotonin reuptake inhibitors on 8-OH-DPAT induced facilitation of ejaculation in rats: comparison of fluvoxamine and paroxetine. Psychopharmacology 179:509–515
De Jong TR, Veening JG, Waldinger MD, Cools AR, Olivier B (2006) Serotonin and the neurobiology of the ejaculation threshold. Neurosci Biobehav Rev 30:893–907
De Jong TR, Veening JG, Olivier B, Waldinger MD (2007) Oxytocin involvement in SSRI-induced delayed ejaculation: a review of animal studies. J Sex Med 4:14–28
Dornan WA, Katz JL, Ricaurte GA (1991) The effects of repeated administration of MDMA on the expression of sexual behaviour in the male rat. Pharmacol Biochem Behav 39:813–816
Ferrari F, Giuliani D (1994) The selective D-2 dopamine-receptor antagonist eticlopride counteracts the ejaculatio-praecox induced by the selective D-2-dopamine agonist SND-919 in the rat. Life Sci 55:1155–1162
Foreman MM, Hall JL, Love RL (1992) Effects of fenfluramine and para-chloroamphetamine on sexual behaviour of male rats. Psychopharmacology 107:327–330
Frank JL, Hendricks SE, Olson CH (2000) Multiple ejaculations and chronic fluoxetine: effects on male rat copulatory behaviour. Pharmacol Biochem Behav 66:337–342
Frye CA, Petralia SM, Rhodes ME, Stein B (2003) Fluoxetine may influence lordosis of rats through effects on midbrain 3 alpha, 5 alpha-THP concentrations. Ann RNY Acad Sci 1007:37–41
Gonzales G, Mendoza L, Ruiz J, Torrejon J (1982) A demonstration that 5-hydroxytryptamine administered peripherally can affect sexual behaviour in male rats. Life Sci 31:2775–2781
Haddjeri N, Blier P, De Montigny C (1998) Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors. J Neurosci 18:10150–10156
Haensel SM, Slob AK (1997) Flesinoxan: a prosexual drug for male rats. Eur J Pharmacol 330:1–9
Hillegaart V, Ahlenius S (1998) Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5-HT1A and 5-HT1B receptor agonists 8-OH-DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD-299 and NAS-181. Br J Pharmacol 125:1733–1743
Hunter AJ, Hole DR, Wilson CA (1985) Studies into the dual effects of serotonergic pharmacological agents on female sexual behaviour in the rat: preliminary evidence that endogenous 5-HT is stimulatory. Pharmacol Biochem Behav 22:5–13
Kendurkar A, Kaur B (2008) Major depressive disorder, obsessive-compulsive disorder, and generalized anxiety disorder: do the sexual dysfunctions differ? Primary Care Companion J Clin Psychiatry 10:299–305
Kennedy SH, Rizvi S (2009) Sexual dysfunction, depression, and the impact of antidepressants. J Clin Psychopharmacol 29:157–164
Klint T, Larsson K (1995) Clozapine acts as a 5-HT2 antagonist by attenuating DOI-induced inhibition of male rat sexual behaviour. Psychopharmacology 119:291–294
Klint T, Dahlgren IL, Larsson K (1992) The selective 5-HT2 receptor antagonist amperozide attenuates 1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane-induced inhibition of male rat sexual behaviour. Eur J Pharmacol 212:241–246
Kugaya A, Seneca NM, Snyder PJ, Williams SA, Malison RT, Baldwin RM, Seibyl JP, Innis RB (2003) Changes in human in vivo serotonin and dopamine transporter availabilities during chronic antidepressant administration. Neuropsychopharmacology 28:413–420
Le Poul E, Boni C, Hanoun N, Laporte AM, Laaris N, Chauveau J, Hamon M, Lanfumey L (2000) Differential adaptation of brain 5-HT1A and 5-HT1B receptors and 5-HT transporter in rats treated chronically with fluoxetine. Neuropharmacology 39:110–122
Leyton M, Stewart J (1996) Acute and repeated activation of male sexual behaviour by tail pinch: opioid and dopaminergic mechanisms. Physiol Behav 60:77–85
Looney C, Thor KB, Ricca D, Marson L (2005) Differential effects of simultaneous or sequential administration of paroxetine and WAY-100, 635 on ejaculatory behaviour. Pharmacol Biochem Behav 82:427–433
Maswood N, Sarkar J, Uphouse L (2008) Modest effects of repeated fluoxetine on estrous cyclicity and sexual behaviour in Sprague Dawley female rats. Brain Res 1745:53–60
Matuszcyk JV, Larsson K, Eriksson E (1998) The selective serotonin reuptake inhibitor fluoxetine reduces sexual motivation in male rats. Pharmacol Biochem Behav 60:527–532
Matuszewich L, Lorrain DS, Trujillo R, Dominguez J, Putnam SK, Hull EM (1999) Partial antagonism of 8-OH-DPAT's effects on male rat sexual behaviour with a D2, but not a 5-HT1A antagonist. Brain Res 820:55–62
Melis MR, Argiolas A (1995) Dopamine and sexual behaviour. Neurosci Biobehav Rev 19:19–38
Mendelson SD (1992) A review and reevaluation of the role of serotonin in the modulation of lordosis behaviour in the female rat. Neurosci Biobehav Rev 16:309–350
Mendelson SD, Gorzalka BB (1985) A facilitatory role for serotonin in the sexual behaviour of the female rat. Pharmacol Biochem Behav 22:1025–1033
Mendelson SD, Gorzalka BB (1986) 5-HT1A receptors: differential involvement in female and male sexual behaviour in the rat. Eur J Pharmacol 132:323–326
Mendelson SD, Gorzalka BB (1990) Sex differences in the effects of 1-(m-trifluoromethylphenyl) piperazine an 1-(m-chlorophenyl) piperazine on copulatory behaviour in the rat. Neuropharmacology 29:783–786
Montgomery SA, Baldwin DS, Riley A (2002) Antidepressant medications: a review of the evidence for drug-induced sexual dysfunction. J Affect Disord 69(1–3):119–140
Mos J, Olivier B, Bloetjes K, Poth M (1990) Drug-induced facilitation of sexual behaviour in the male rat: behavioural and pharmacological aspects. In: Slob AK, Baum MJ (eds) Psychoneuroendocrinology of growth and development. Medicom Publishers, Rotterdam, pp 221–232
Mos J, Van Logten J, Bloetjes K, Olivier B (1991) The effects of idazoxan and 8-OH-DPAT on sexual behaviour and associated ultrasonic vocalizations in the rat. Neurosci Biobehav Rev 15:505–515
Mos J, Mollet I, Tolboom JTBM, Waldinger MD, Olivier B (1999) A comparison of the effects of different serotonin reuptake blockers on sexual behaviour of the male rat. Eur Neuropsychopharmacol 9:123–135
Murphy DL, Lesch KP (2008) Targeting the murine serotonin transporter insights into human neurobiology. Nat Rev Neurosci 9:85–96
Olivier J, Cools A, Ellenbroek B, Cuppen E, Homberg J (2010) The serotonin transporter knock-out rat: a review. In Kalueff AV, LaPorte JL (eds) Experimental models in serotonin transporter research. Cambridge University Press, Cambridge, PP170–213
Pattij T, de Jong TR, Uitterdijk A, Waldinger MD, Veening JG, Cools AR, van der Graaf PH, Olivier B (2005) Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders. Eur J Neurosci 22:724–734
Regitz-Zagrosek V, Schubert C, Krüger S (2008) Gesclechterunterschiede in der neuropsychiatrischen Pharmakotherapie. Der Internist 12:1516–1523
Sarkar J, Hiegel C, Ginis E, Hilbun E, Uphouse L (2008) Subchronic treatment with fluoxetine attenuates effects of acute fluoxetine on female rat sexual behaviour. Brain Res 1190:58–64
Siddiqui A, Niazi A, Shahariar S, Wilson CA (2007) The 5-Ht(7) receptor is involved in the regulation of female sexual behaviour in the rat. Pharmacol Biochem Behave 87:386–392
Smits BM, Mudde JB, van de Belt J, Verheul M, Olivier JD, Homberg J, Gurvey V, Cools AR, Ellenbroek BA, Cuppen E (2006) Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target selected mutagenesis. Pharmacogenet Genomics 16:159–169
Snoeren EMS, Chan JSW, De Jong TR, Cuppen E, Waldinger MD, Olivier B, Oosting RS (2010) Serotonin transporter null mutation and sexual behaviour in female rats: 5-HT1A receptor desensitization. J Sex Med 7:2424–2434
Sugden K, Tichopad A, Khan N, Craig IW, D’Souza UM (2009) Genes within the serotonergic system are differentially expressed I the human brain. BMC Neurosci 10:50
Sura A, Overstreet DH, Marson L (2001) Selectively bred male rat lines differ in naïve and experienced sexual behaviour. Physiol Behav 72:13–20
Tagliamonte A, Tagliamonte P, Gessa GL, Brodie BB (1969) Compulsive sexual activity induced by p-chlorophenylalanine in normal and pinealectomized male rats. Science 166:1433–1435
Uphouse L (2000) Female gonadal hormones, serotonin and sexual receptivity. Brain Res Rev 33:242–257
Uphouse L, Guptarak J (2010) Serotonin and sexual behaviour. In: Müller C, Jacobs B (eds) Handbook of behavioural neurobiology of serotonin. Elsevier, Amsterdam, pp 347–365
Uphouse L, Hiegel C, Guptarak J, Maswood N (2009) Progesterone reduces the effect of the serotonin 1B/1D receptor antagonist GR127935, on lordosis behaviour. Horm Behav 55(1):169–174
Waldinger MD (2002) The neurobiological approach to premature ejaculation (review article). J Urol 168:2359–2367
Waldinger MD, Hengeveld MW, Zwinderman AH, Olivier B (1998) Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. J Clin Psychopharmacol 18:274–281
Waldinger MD, Plas A vd, Pattij T, Oorschot R v, Coolen LM, Veening JG, Olivier B (2001a) The SSRIs fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatment. Psychopharmacology 160:283–289
Waldinger MD, Zwinderman AH, Olivier B (2001b) SSRIs and ejaculation: a double-blind, randomized, fixed-dose study with paroxetine and citalopram. J Clin Psychopharmacol 21:556–560
Wang L, Hull EM (1980) Tail pinch induces sexual behaviour in olfactory bulbectomized male rats. Physiol Behav 24:211–215
Watson NV, Gorzalka BB (1991) DOI-induced inhibition of copulatory behaviour in male rats: reversal by 5-HT2 antagonists. Pharmacol Biochem Behav 39:605–621
Williams VSL, Baldwin DS, Hogue SL, Fehnel SE, Hollis KA, Edin HM (2006) Estimating the prevalence and impact of antidepressant-induced sexual dysfunction in 2 European countries< a cross-sectional patient survey. J Clin Psychiatry 67:204–210
Zemishlany Z, Weizman A (2008) The impact of mental illness on sexual dysfunction. Adv Psychosom Med 29:89–106
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Olivier, B. et al. (2010). Differences in Sexual Behaviour in Male and Female Rodents: Role of Serotonin. In: Neill, J., Kulkarni, J. (eds) Biological Basis of Sex Differences in Psychopharmacology. Current Topics in Behavioral Neurosciences, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2010_116
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