Abstract
Antimicrobial resistance (AMR) is a global threat as the existing health care may become ineffective. Antibiotics, antibiotic-resistant bacteria (ARB), and antibiotic resistance genes (ARGs) considered as emerging contaminants are the three major components of AMR. India is one of the largest consumers of antibiotics with defined daily dose (DDD) of 4,950 per 1,000 population in 2015. By 2030, therapeutic and nontherapeutic use of antibiotics in veterinary animals is projected to increase by 18%. Antibiotics, ARB, and ARGs in the solid and liquid waste generated enter the environment via different pathways. The major sources of antibiotics, ARB, and ARG include domestic, hospital, and pharmaceutical industry wastewater apart from the solid/liquid waste generated from veterinary and food animals. Existing conventional wastewater treatment technologies like activated sludge process (ASP) do not ensure complete removal of antibiotics, ARB, and ARGs from wastewater. Similarly, the sludge generated find its way to agriculture land and eventually spread resistance in the environment. Once introduced in the environment, elimination of these contaminants is difficult. India’s action plan on AMR in 2017 regulates antibiotic use for human and animal and addresses environment AMR spread from all possible sources and containment. In 2020, the Government of India introduced discharge standard for 121 antibiotics in the effluents of bulk drug manufacturing industries, formulation industries, and common effluent treatment plant (CETP) receiving pharmaceutical wastewater.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Prabhasankar VP et al (2016) Removal rates of antibiotics in four sewage treatment plants in South India. Environ Sci Pollut Res 23(9):8679–8685. https://doi.org/10.1007/s11356-015-5968-3
Laxminarayan R et al (2013) Antibiotic resistance – the need for global solutions. Lancet Infect Dis 13(12):1057–1098. https://doi.org/10.1016/S1473-3099(13)70318-9
The Center for Disease Dynamics Economics & Policy (2018) Resistance map: antibiotic resistance. https://resistancemap.cddep.org/. Accessed 14 Jun 2019
Goossens H (2009) Antibiotic consumption and link to resistance. Clin Microbiol Infect 15:12–15. https://doi.org/10.1111/j.1469-0691.2009.02725.x
Kümmerer K (2009) Antibiotics in the aquatic environment – a review – part I. Chemosphere 75(4):417–434. https://doi.org/10.1016/j.chemosphere.2008.11.086
Larsson DGJ, de Pedro C, Paxeus N (2007) Effluent from drug manufactures contains extremely high levels of pharmaceuticals. J Hazard Mater 148(3):751–755. https://doi.org/10.1016/j.jhazmat.2007.07.008
Kümmerer K (2009) Antibiotics in the aquatic environment – a review – part II. Chemosphere 75(4):435–441. https://doi.org/10.1016/j.chemosphere.2008.12.006
Philip JM, Aravind UK, Aravindakumar CT (2018) Emerging contaminants in Indian environmental matrices – a review. Chemosphere 190:307–326. https://doi.org/10.1016/j.chemosphere.2017.09.120
Peripi SB, Thadepalli VGR, Khagga M, Tripuraribhatla PK, Bharadwaj DK (2012) Profile of antibiotic consumption, sensitivity and resistance in an urban area of Andhra Pradesh, India. Singap Med J 53(4):268–272
Akiba M et al (2015) Impact of wastewater from different sources on the prevalence of antimicrobial-resistant Escherichia coli in sewage treatment plants in South India. Ecotoxicol Environ Saf 115:203–208. https://doi.org/10.1016/j.ecoenv.2015.02.018
Van Boeckel TP et al (2014) Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. Lancet Infect Dis 14(8):742–750. https://doi.org/10.1016/S1473-3099(14)70780-7
Kumari Indira KS, Chandy SJ, Jeyaseelan L, Rashmi K, Saradha S (2008) Antimicrobial prescription patterns for common acute infections insome rural & urban health facilities of India. Indian J Med Res 128:165–171
Walsh TR, Weeks J, Livermore DM, Toleman MA (2011) Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study. Lancet Infect Dis 11(5):355–362. https://doi.org/10.1016/S1473-3099(11)70059-7
Morgan DJ, Okeke IN, Laxminarayan R, Perencevich EN, Weisenberg S (2011) Non-prescription antimicrobial use worldwide: a systematic review. Lancet Infect Dis 11(9):692–701. https://doi.org/10.1016/S1473-3099(11)70054-8
Kotwani A, Wattal C, Joshi PC, Holloway K (2012) Irrational use of antibiotics and role of the pharmacist: an insight from a qualitative study in New Delhi, India. J Clin Pharm Ther 37(3):308–312. https://doi.org/10.1111/j.1365-2710.2011.01293.x
Kotwani A, Wattal C, Katewa S, Joshi PC, Holloway K (2010) Factors influencing primary care physicians to prescribe antibiotics in Delhi India. Fam Pract 27(6):684–690. https://doi.org/10.1093/fampra/cmq059
Chandy SJ (2008) Consequences of irrational use of antibiotics. Indian J Med Ethics 5(4):174–175. https://doi.org/10.20529/IJME.2008.064
Sivagnanam G, Mohanasundaram J, Thirumalaikolundusubramanian P, Raaj AA, Namasivayam K, Rajaram S (2004) A survey on current attitude of practicing physicians upon usage of antimicrobial agents in southern part of India. MedGenMed, 6(2). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1395775/. Accessed 14 Jun 2019
Kaur A et al (2018) A study of antibiotic prescription pattern in patients referred to tertiary care center in northern India. Ther Adv Infect Dis 5(4):63–68. https://doi.org/10.1177/2049936118773216
You Y, Silbergeld EK (2014) Learning from agriculture: understanding low-dose antimicrobials as drivers of resistome expansion. Front Microbiol 5. https://doi.org/10.3389/fmicb.2014.00284
Subedi B, Balakrishna K, Sinha RK, Yamashita N, Balasubramanian VG, Kannan K (2015) Mass loading and removal of pharmaceuticals and personal care products, including psychoactive and illicit drugs and artificial sweeteners, in five sewage treatment plants in India. J Environ Chem Eng 3(4, Part A):2882–2891. https://doi.org/10.1016/j.jece.2015.09.031
Boeckel TPV et al (2017) Reducing antimicrobial use in food animals. Science 357(6358):1350–1352. https://doi.org/10.1126/science.aao1495
Van Boeckel TP et al (2015) Global trends in antimicrobial use in food animals. Proc Natl Acad Sci U S A 112(18):5649–5654. https://doi.org/10.1073/pnas.1503141112
Annual Report (2017–2018) Department of Animal Husbandry, Dairying and Fisheries, Ministry of Agricultureand Farmers Welfare. http://dadf.gov.in/sites/default/filess/annual_report_17-18.pdf. Accessed 17 Nov 2019
Chauhan SL, Priyanka, Garg SR, Jadhav VJ (2019) Determination of tetracycline residues in milk by high performance liquid chromatography. Int J Curr Microbiol Appl Sci 8(2):2763–2771. https://doi.org/10.20546/ijcmas.2019.802.324
Sahu R, Saxena P, Mathur HB, Agarwal HC (2014) Antibiotics in chicken meat. Center for Science and Environment. http://re.indiaenvironmentportal.org.in/files/file/Antibiotics%20in%20Chicken_Lab%20Report_Final%2029%20July.pdf. Accessed 27 Jun 2019
Stockton B, Davies M, Meesaraganda R (2018) Zoetis and its antibiotics for growth in India. Vet Rec 183(14):432–433. https://doi.org/10.1136/vr.k4278
Jayalakshmi K, Paramasivam M, Sasikala M, Tamilam T, Sumithra A (2017) Review on antibiotic residues in animal products and its impact on environments and human health. J Entomol Zool Stud 5(3):1446–14451
Massé DI, Saady NMC, Gilbert Y (2014) Potential of biological processes to eliminate antibiotics in livestock manure: an overview. Animals 4(2):146–163. https://doi.org/10.3390/ani4020146
Kibuye FA et al (2019) Fate of pharmaceuticals in a spray-irrigation system: from wastewater to groundwater. Sci Total Environ 654:197–208. https://doi.org/10.1016/j.scitotenv.2018.10.442
Balakrishna K, Rath A, Praveenkumarreddy Y, Guruge KS, Subedi B (2017) A review of the occurrence of pharmaceuticals and personal care products in Indian water bodies. Ecotoxicol Environ Saf 137:113–120. https://doi.org/10.1016/j.ecoenv.2016.11.014
Saha S et al (2018) Assessing the suitability of sewage-sludge produced in Kolkata, India for their agricultural use. Proc Indian Natl Sci Acad 97. https://doi.org/10.16943/ptinsa/2018/49410
Singh P, Mondal T, Sharma R, Mahalakshmi N, Gupta M (2018) Poultry waste management. Int J Curr Microbiol App Sci 7(8):694–700. https://doi.org/10.20546/ijcmas.2018.708.076
Li X, Pletcher D, Walsh FC (2011) Electrodeposited lead dioxide coatings. Chem Soc Rev 40(7):3879–3894. https://doi.org/10.1039/C0CS00213E
Ambesh P, Ambesh SP (2016) Open defecation in India: a major health hazard and hurdle in infection control. J Clin Diagn Res 10(7):IL01–IL02. https://doi.org/10.7860/JCDR/2016/20723.8098
Kumar A, Pal D (2018) Antibiotic resistance and wastewater: correlation, impact and critical human health challenges. J Environ Chem Eng 6(1):52–58. https://doi.org/10.1016/j.jece.2017.11.059
Marathe NP, Pal C, Gaikwad SS, Jonsson V, Kristiansson E, Larsson DGJ (2017) Untreated urban waste contaminates Indian river sediments with resistance genes to last resort antibiotics. Water Res 124:388–397. https://doi.org/10.1016/j.watres.2017.07.060
Dhawde R, Macaden R, Saranath D, Nilgiriwala K, Ghadge A, Birdi T (2018) Antibiotic resistance characterization of environmental E. coli isolated from river Mula-Mutha, Pune District, India. Int J Environ Res Public Health 15(6). https://doi.org/10.3390/ijerph15061247
Diwan V, Tamhankar AJ, Aggarwal M, Sen S, Khandal RK, Lundborg CS (2009) Detection of antibiotics in hospital effluents in India. Curr Sci 97(12):4
Mutiyar PK, Mittal AK (2014) Occurrences and fate of selected human antibiotics in influents and effluents of sewage treatment plant and effluent-receiving river Yamuna in Delhi (India). Environ Monit Assess 186(1):541–557. https://doi.org/10.1007/s10661-013-3398-6
Divya SP, Hatha AAM (2019) Screening of tropical estuarine water in south-west coast of India reveals emergence of ARGs-harboring hypervirulent Escherichia coli of global significance. Int J Hyg Environ Health 222(2):235–248. https://doi.org/10.1016/j.ijheh.2018.11.002
Laroche E, Pawlak B, Berthe T, Skurnik D, Petit F (2009) Occurrence of antibiotic resistance and class 1, 2 and 3 integrons in Escherichia coli isolated from a densely populated estuary (seine, France). FEMS Microbiol Ecol 68(1):118–130. https://doi.org/10.1111/j.1574-6941.2009.00655.x
Dhawde R, Macaden R, Ghadge A, Birdi T (2018) Seasonal prevalence of antibiotic-resistant bacteria in the river Mula-Mutha, India. Environ Monit Assess 190(9):533. https://doi.org/10.1007/s10661-018-6911-0
Diwan V et al (2010) Antibiotics and antibiotic-resistant bacteria in waters associated with a hospital in Ujjain, India. BMC Public Health 10(1):414. https://doi.org/10.1186/1471-2458-10-414
Mohapatra S, Huang C-H, Mukherji S, Padhye LP (2016) Occurrence and fate of pharmaceuticals in WWTPs in India and comparison with a similar study in the United States. Chemosphere 159:526–535. https://doi.org/10.1016/j.chemosphere.2016.06.047
Velpandian T et al (2018) Un-segregated waste disposal: an alarming threat of antimicrobials in surface and ground water sources in Delhi. Environ Sci Pollut Res 25(29):29518–29528. https://doi.org/10.1007/s11356-018-2927-9
Gothwal R, Thatikonda S (2017) Role of environmental pollution in prevalence of antibiotic resistant bacteria in aquatic environment of river: case of Musi river, South India. Water Environ J 31(4):456–462. https://doi.org/10.1111/wej.12263
Diwan V et al (2018) Seasonal variations in water-quality, antibiotic residues, resistant bacteria and antibiotic resistance genes of escherichia coli isolates from water and sediments of the Kshipra River in Central India. Int J Environ Res Public Health 15(6):1281. https://doi.org/10.3390/ijerph15061281
Ramaswamy BR, Shanmugam G, Velu G, Rengarajan B, Larsson DGJ (2011) GC–MS analysis and ecotoxicological risk assessment of triclosan, carbamazepine and parabens in Indian rivers. J Hazard Mater 186(2):1586–1593. https://doi.org/10.1016/j.jhazmat.2010.12.037
Gao J, Pedersen JA (2005) Adsorption of sulfonamide antimicrobial agents to clay minerals. Environ Sci Technol 39(24):9509–9516. https://doi.org/10.1021/es050644c
Devarajan N et al (2016) Occurrence of antibiotic resistance genes and bacterial markers in a tropical river receiving hospital and urban wastewaters. PLoS One 11(2). https://doi.org/10.1371/journal.pone.0149211
Li D et al (2010) Antibiotic resistance characteristics of environmental bacteria from an oxytetracycline production wastewater treatment plant and the receiving river. Appl Environ Microbiol 76(11):3444–3451. https://doi.org/10.1128/AEM.02964-09
Diwan V, Chandran SP, Tamhankar AJ, Stålsby Lundborg C, Macaden R (2012) Identification of extended-spectrum β-lactamase and quinolone resistance genes in Escherichia coli isolated from hospital wastewater from Central India. J Antimicrob Chemother 67(4):857–859. https://doi.org/10.1093/jac/dkr564
Kurasam J, Sihag P, Mandal PK, Sarkar S (2018) Presence of fluoroquinolone resistance with persistent occurrence of gyrA gene mutations in a municipal wastewater treatment plant in India. Chemosphere 211:817–825. https://doi.org/10.1016/j.chemosphere.2018.08.011
Gullberg E et al (2011) Selection of resistant bacteria at very low antibiotic concentrations. PLOS Pathogens 7(7):e1002158. https://doi.org/10.1371/journal.ppat.1002158
Andersson DI, Hughes D (2012) Evolution of antibiotic resistance at non-lethal drug concentrations. Drug Resist Updat 15(3):162–172. https://doi.org/10.1016/j.drup.2012.03.005
Rizzo L et al (2013) Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review. Sci Total Environ 447:345–360. https://doi.org/10.1016/j.scitotenv.2013.01.032
Singh SK, Ekka R, Mishra M, Mohapatra H (2017) Association study of multiple antibiotic resistance and virulence: a strategy to assess the extent of risk posed by bacterial population in aquatic environment. Environ Monit Assess 189(7):320. https://doi.org/10.1007/s10661-017-6005-4
Burmeister AR (2015) Horizontal gene transfer. Evol Med Public Health 2015(1):193–194. https://doi.org/10.1093/emph/eov018
Lamba M, Ahammad SZ (2017) Sewage treatment effluents in Delhi: a key contributor of β-lactam resistant bacteria and genes to the environment. Chemosphere 188:249–256. https://doi.org/10.1016/j.chemosphere.2017.08.133
Lamba M, Gupta S, Shukla R, Graham DW, Sreekrishnan TR, Ahammad SZ (2018) Carbapenem resistance exposures via wastewaters across New Delhi. Environ Int 119:302–308. https://doi.org/10.1016/j.envint.2018.07.004
Diwan V et al (2017) A three-year follow-up study of antibiotic and metal residues, antibiotic resistance and resistance genes, focusing on Kshipra – a river associated with holy religious mass-bathing in India: protocol paper. Int J Environ Res Public Health 14(6):574. https://doi.org/10.3390/ijerph14060574
Gothwal R, Shashidhar T (2017) Proliferation of ciprofloxacin resistant Bacteria in polluted sediments of Musi River, India. Soil Sediment Contam Int J 26(5):501–509. https://doi.org/10.1080/15320383.2017.1355352
Bajaj P, Singh NS, Kanaujia PK, Virdi JS (2015) Distribution and molecular characterization of genes encoding CTX-M and AmpC β-lactamases in Escherichia coli isolated from an Indian urban aquatic environment. Sci Total Environ 505:350–356. https://doi.org/10.1016/j.scitotenv.2014.09.084
Siddiqui MT, Mondal AH, Sultan I, Ali A, Haq QMR (2018) Co-occurrence of ESBLs and silver resistance determinants among bacterial isolates inhabiting polluted stretch of river Yamuna, India. Int J Environ Sci Technol 16:5611. https://doi.org/10.1007/s13762-018-1939-9
Mondal AH, Siddiqui MT, Sultan I, Haq QMR (2019) Prevalence and diversity of blaTEM, blaSHV and blaCTX-M variants among multidrug resistant Klebsiella spp. from an urban riverine environment in India. Int J Environ Health Res 29(2):117–129. https://doi.org/10.1080/09603123.2018.1515425
Skariyachan S et al (2015) Environmental monitoring of bacterial contamination and antibiotic resistance patterns of the fecal coliforms isolated from Cauvery River, a major drinking water source in Karnataka, India. Environ Monit Assess 187(5):279. https://doi.org/10.1007/s10661-015-4488-4
Mathews EB et al (2018) Occurrence and antibiotic susceptibility testing of Vibrio cholerae from district Wayanad, Kerala, India. Proc Natl Acad Sci India Sect B Biol Sci 88(2):673–678. https://doi.org/10.1007/s40011-016-0799-7
Purohit MR, Chandran S, Shah H, Diwan V, Tamhankar AJ, Stålsby Lundborg C (2017) Antibiotic resistance in an Indian rural community: a ‘one-health’ observational study on commensal coliform from humans, animals, and water. Int J Environ Res Public Health 14(4):386. https://doi.org/10.3390/ijerph14040386
Maloo A, Fulke AB, Mulani N, Sukumaran S, Ram A (2017) Pathogenic multiple antimicrobial resistant Escherichia coli serotypes in recreational waters of Mumbai, India: a potential public health risk. Environ Sci Pollut Res 24(12):11504–11517. https://doi.org/10.1007/s11356-017-8760-8
Sneha KG et al (2016) Distribution of multiple antibiotic resistant Vibrio spp across Palk Bay. Reg Stud Mar Sci 3:242–250. https://doi.org/10.1016/j.rsma.2015.11.004
Meena B et al (2015) Enterococcus species diversity and molecular characterization of biomarker genes in enterococcus faecalis in Port Blair Bay, Andaman and Nicobar Islands, India. Mar Pollut Bull 94(1):217–227. https://doi.org/10.1016/j.marpolbul.2015.02.027
Kumar S, Tripathi VR, Vikram S, Kumar B, Garg SK (2018) Characterization of MAR and heavy metal-tolerant E. coli O157:H7 in water sources: a suggestion for behavioral intervention. Environ Dev Sustain 20(6):2447–2461. https://doi.org/10.1007/s10668-017-9998-5
Mishra RK et al (2017) Bacterial diversity and antibiotic resistance in a wetland of Lakhimpur-Kheri, Uttar Pradesh, India. J Environ Biol 38(1):55–66. https://doi.org/10.22438/jeb/38/1/MS-117
Tallur PN et al (2016) Characterization of antibiotic resistant and enzyme producing bacterial strains isolated from the Arabian Sea. 3 Biotech 6(1):28. https://doi.org/10.1007/s13205-015-0332-3
Kalaiselvi K, Mangayarkarasi V, Balakrishnan D, Chitraleka V (2016) Survival of antibacterial resistance microbes in hospital-generated recycled wastewater. J Water Health 14(6):942–949. https://doi.org/10.2166/wh.2016.154
Lamba M, Graham DW, Ahammad SZ (2017) Hospital wastewater releases of Carbapenem-resistance pathogens and genes in urban India. Environ Sci Technol 51(23):13906–13912. https://doi.org/10.1021/acs.est.7b03380
Chandran SP et al (2014) Detection of carbapenem resistance genes and cephalosporin, and quinolone resistance genes along with oqxAB gene in Escherichia coli in hospital wastewater: a matter of concern. J Appl Microbiol 117(4):984–995. https://doi.org/10.1111/jam.12591
Kumar H et al (2014) Prevalence of multidrug-resistant, coagulase-positive Staphylococcus aureus in nasal carriage, food, wastewater and paper currency in Jalandhar city (north-western), an Indian state of Punjab. Environ Monit Assess 187(1):4134. https://doi.org/10.1007/s10661-014-4134-6
Tibrewal MA, Rajesh N, Rajesh V (2018) Identification and characterization of the microbial communities found in electronic industrial effluent and their potential for bioremediation. Ecotoxicol Environ Saf 164:379–387. https://doi.org/10.1016/j.ecoenv.2018.08.018
Sundaramanickam A, Suresh Kumar P, Kumaresan S, Balasubramanian T (2015) Isolation and molecular characterization of multidrug-resistant halophilic bacteria from shrimp farm effluents of Parangipettai coastal waters. Environ Sci Pollut Res 22(15):11700–11707. https://doi.org/10.1007/s11356-015-4427-5
Saha S, Saha BN, Pati S, Pal B, Hazra GC (2018) Agricultural use of sewage sludge in India: benefits and potential risk of heavy metals contamination and possible remediation options – a review. Int J Environ Technol Manag 20(3/4):183–199. https://doi.org/10.1504/IJETM.2017.089645
Mohamed Amanullah M, Sekar S, Muthukrishnan P (2010) Prospects and potential of poultry manure. Asian J Plant Sci 9(4):172–182. https://doi.org/10.3923/ajps.2010.172.182
Gupta KK, Aneja KR, Rana D (2016) Current status of cow dung as a bioresource for sustainable development. Bioresour Bioprocess 3(1):28. https://doi.org/10.1186/s40643-016-0105-9
He Y et al (2020) Antibiotic resistance genes from livestock waste: occurrence, dissemination, and treatment. NPJ Clean Water 3(1):1–11. https://doi.org/10.1038/s41545-020-0051-0
Allen HK, Donato J, Wang HH, Cloud-Hansen KA, Davies J, Handelsman J (2010) Call of the wild: antibiotic resistance genes in natural environments. Nat Rev Microbiol 8(4):251–259. https://doi.org/10.1038/nrmicro2312
Bag S et al (2018) Molecular insights into antimicrobial resistance traits of commensal human gut microbiota. Microb Ecol 77:546. https://doi.org/10.1007/s00248-018-1228-7
Lamba M, Ahammad SZ (2017) Performance comparison of secondary and tertiary treatment systems for treating antibiotic resistance. Water Res 127:172–182. https://doi.org/10.1016/j.watres.2017.10.025
Zhang X-X, Zhang T, Fang HHP (2009) Antibiotic resistance genes in water environment. Appl Microbiol Biotechnol 82(3):397–414. https://doi.org/10.1007/s00253-008-1829-z
Ahammad ZS, Sreekrishnan TR, Hands CL, Knapp CW, Graham DW (2014) Increased waterborne blaNDM-1 resistance gene abundances associated with seasonal human pilgrimages to the upper Ganges River. Environ Sci Technol 48(5):3014–3020. https://doi.org/10.1021/es405348h
Singh G, Vajpayee P, Rani N, Amoah ID, Stenström TA, Shanker R (2016) Exploring the potential reservoirs of non specific TEM beta lactamase (blaTEM) gene in the indo-Gangetic region: a risk assessment approach to predict health hazards. J Hazard Mater 314:121–128. https://doi.org/10.1016/j.jhazmat.2016.04.036
Marathe NP et al (2013) A treatment plant receiving waste water from multiple bulk drug manufacturers is a reservoir for highly multi-drug resistant integron-bearing bacteria. PLOS One 8(10):e77310. https://doi.org/10.1371/journal.pone.0077310
Bailey JK, Pinyon JL, Anantham S, Hall RM (2010) Commensal Escherichia coli of healthy humans: a reservoir for antibiotic-resistance determinants. J Med Microbiol 59(11):1331–1339. https://doi.org/10.1099/jmm.0.022475-0
Bajaj P, Kanaujia PK, Singh NS, Sharma S, Kumar S, Virdi JS (2016) Quinolone co-resistance in ESBL- or AmpC-producing Escherichia coli from an Indian urban aquatic environment and their public health implications. Environ Sci Pollut Res 23(2):1954–1959. https://doi.org/10.1007/s11356-015-5609-x
National status of waste water generation & treatment:Inventorization of Sewage Treatment Plants,Central Pollution Control Board, Ministry of Environment and Forests. http://www.sulabhenvis.nic.in/Database/STST_wastewater_2090.aspx. Accessed 17 Nov 2019
Sewage/Wastewater Treatment Technologies,National River Conservation Directorate Ministry of Jal Shakti Department of Water Resources, River Development & Ganga Rejuvenation Government of India. https://nrcd.nic.in/writereaddata/FileUpload/69307246Technologies.pdf. Accessed 5 Feb 2019
Mutiyar PK, Mittal AK (2013) Occurrences and fate of an antibiotic amoxicillin in extended aeration-based sewage treatment plant in Delhi, India: a case study of emerging pollutant. Desalin Water Treat 51(31–33):6158–6164. https://doi.org/10.1080/19443994.2013.770199
WHO, United Nations’ Children’s Fund (2015) Water, sanitation and hygiene in health care facilities Status in low- and middle-income countries and way forward. https://apps.who.int/iris/bitstream/handle/10665/154588/9789241508476_eng.pdf;jsessionid=B43B935B4DE8DF4405CF21D08970F0E1?sequence=1. Accessed 17 Nov 2019
Kümmerer K, Henninger A (2003) Promoting resistance by the emission of antibiotics from hospitals and households into effluent. Clin Microbiol Infect 9(12):1203–1214. https://doi.org/10.1111/j.1469-0691.2003.00739.x
Praveenkumarreddy Y, Akiba M, Guruge KS, Balakrishna K, Vandana KE, Kumar V (2020) Occurrence of antimicrobial-resistant Escherichia coli in sewage treatment plants of South India. J Water Sanitation Hygiene Dev 10(1):48–55. https://doi.org/10.2166/washdev.2020.051
Aggarwal A, Bhalla M, Fatima KH (2020) Detection of New Delhi metallo-beta-lactamase enzyme gene blaNDM-1 associated with the Int-1 gene in gram-negative bacteria collected from the effluent treatment plant of a tuberculosis care hospital in Delhi, India. Access Microbiol. https://doi.org/10.1099/acmi.0.000125
Gandra S, Joshi J, Trett A, Sankhil Lamkang A, Laxminarayan R (2017) Scoping report on Antimicrobial Resistance in India. Center for Disease Dynamics, Economics & Policy, Washington. https://cddep.org/wp-content/uploads/2017/11/AMR-INDIA-SCOPING-REPORT.pdf
Global Action Plan on Antimicrobial Resistance, 2014,World Health Organisation (2015). https://apps.who.int/iris/bitstream/handle/10665/193736/9789241509763_eng.pdf?sequence=1. Accessed 27 Jun 2019
National Policy for Containment of Antimicrobial Resistance in India.Ministry of Health and Family Welfare (2011). https://mohfw.gov.in/sites/default/files/3203490350abpolicy%20%281%29.pdf. Accessed 27 Jun 2019
Jaipur Declaration on Antimicrobial Resistance (2011) Ministry of health and family welfare and WHO. http://www.searo.who.int/entity/antimicrobial_resistance/rev_jaipur_declaration_2014.pdf?ua=1. Accessed 27 Jun 2019
Team C (2014) ‘Chennai declaration’: 5-year plan to tackle the challenge of anti-microbial resistance. Indian J Med Microbiol 32(3):221–228. https://doi.org/10.4103/0255-0857.129053
Antimicrobial resistance and its containment in India (2016) Ministry of health and family welfare and WHO. http://www.searo.who.int/india/topics/antimicrobial_resistance/amr_containment.pdf. Accessed 27 Jun 2019
National antimicrobial resistance research and surveillance network (AMRSN) (2015) Indian Council of Medical Research. http://pib.nic.in/newsite/PrintRelease.aspx?relid=133016. Accessed 27 Jun 2019
National Treatment Guidelines for Antimicrobial Use in Infectious Diseases (2016) National Center for Disease Control, Directorate General of Health Services. Ministry of Health & Family Welfare. http://pbhealth.gov.in/AMR_guideline7001495889.pdf. Accessed 27 Jun 2019
National Action Plan on Antimicrobial Resistance (NAP AMR 2017–2021) (2017) Ministry of Health and Family Welfare. http://www.searo.who.int/entity/antimicrobial_resistance/national-action-plans/en/. Accessed 27 Jun 2019
Delhi Declaration on Antimicrobial Resistance (2017). http://www.searo.who.int/india/topics/antimicrobial_resistance/delhi_dec_amr.pdf. Accessed 27 Jun 2019
Indian Network for Fishery and Animals Antimicrobial Resistance (INFAAR), FAO in India, Food and Agriculture Organization of the United Nations (2017). http://www.fao.org/india/news/detail-events/en/c/853974/. Accessed 27 Jun 2019
Nafade V et al (2019) Over-the-counter antibiotic dispensing by pharmacies: a standardised patient study in Udupi district, India. BMJ Global Health 4(6):e001869. https://doi.org/10.1136/bmjgh-2019-001869
Swachh Bharat Mission-Gramin, Department of Drinking Water and Sanitation, Ministry of Jal Shakti. https://sbm.gov.in/sbmReport/home.aspx. Accessed 3 May 2020
Environment Protection Amendment Rules, Ministry of Environment, Forest and Climate Change. Authority (2020) https://assets.documentcloud.org/documents/6770398/The-following-draft-of-the-notification-which.pdf. Accessed 4 May 2020
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Sasikaladevi, R., Kiruthika Eswari, V., Nambi, I.M. (2020). Antibiotic Resistance and Sanitation in India: Current Situation and Future Perspectives. In: Manaia, C., Donner, E., Vaz-Moreira, I., Hong, P. (eds) Antibiotic Resistance in the Environment . The Handbook of Environmental Chemistry, vol 91. Springer, Cham. https://doi.org/10.1007/698_2020_608
Download citation
DOI: https://doi.org/10.1007/698_2020_608
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-55064-6
Online ISBN: 978-3-030-55065-3
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)