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The Magnitude of Carbapenemase and ESBL Producing Enterobacteriaceae Isolates from Patients with Urinary Tract Infections at Tikur Anbessa Specialized Teaching Hospital, Addis Ababa, Ethiopia

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References

  • Abayneh M, Tesfaw G, Abdissa A (2018) Isolation of extended-spectrum β-lactamase-(ESBL-) producing Escherichia coli and Klebsiella pneumoniae from patients with community-onset urinary tract infections in Jimma University Specialized Hospital, Southwest Ethiopia. Can J Infect Dis Med Microbiol 2018:4846159

    Article  Google Scholar 

  • Albaramki J, Abdelghani T, Dalaeen A, Khdair Ahmad F, Alassaf A, Odeh R (2019) Urinary tract infection caused by ESBL-producing bacteria: risk factors and antibiotic resistance. Pediatr Int 61(11):1127–1132

    Article  CAS  Google Scholar 

  • Amladi AU, Abirami B, Devi SM, Sudarsanam TD, Kandasamy S, Kekre N, Veeraraghavan B, Sahni RD (2019) Susceptibility profile, resistance mechanisms & efficacy ratios of fosfomycin, nitrofurantoin & colistin for carbapenem-resistant Enterobacteriaceae causing urinary tract infections. Indian J Med Res 149:185

    Article  CAS  Google Scholar 

  • Behzadi P, Urbán E, Matuz M, Benkő R, Gajdács M (2021) The role of gram-negative bacteria in urinary tract infections: current concepts and therapeutic options. Adv Exp Med Biol 1323:35–69

    Article  CAS  Google Scholar 

  • Bharadwaj R, Robinson ML, Balasubramanian U, Kulkarni V, Kagal A, Raichur P, Khadse S, Kadam D, Valvi C, Kinikar A (2018) Drug-resistant Enterobacteriaceae colonization is associated with healthcare utilization and antimicrobial use among inpatients in Pune, India. BMC Infect Dis 18:504

    Article  CAS  Google Scholar 

  • Chander A, Shrestha CD (2013) Prevalence of extended spectrum beta lactamase producing Escherichia coli and Klebsiella pneumoniae urinary isolates in a tertiary care hospital in Kathmandu, Nepal. BMC Res Notes 6:487

    Article  Google Scholar 

  • CLSI (2017) Performance standards for antimicrobial susceptibility testing. Clinical and Laboratory Standards Institute, Wayne

    Google Scholar 

  • CLSI (2018) Performance standards for antimicrobial susceptibility testing. CLSI supplement M100, 28th edn. Clinical and Laboratory Standards Institute, Wayne

    Google Scholar 

  • David S, Reuter S, Harris SR, Glasner C, Feltwell T, Argimon S, Abudahab K, Goater R, Giani T, Errico G (2019) Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread. Nat Microbiol 4:1919–1929

    Article  CAS  Google Scholar 

  • Dayan N, Dabbah H, Weissman I, Aga I, Even L, Glikman D (2013) Urinary tract infections caused by community-acquired extended-spectrum β-lactamase-producing and nonproducing bacteria: a comparative study. J Pediatr 163:1417–1421

    Article  Google Scholar 

  • De La Blanchardière A, Dargère S, Guérin F, Daurel C, Saint-Lorant G, Verdon R, Cattoir V (2015) Non-carbapenem therapy of urinary tract infections caused by extended-spectrum β-lactamase-producing Enterobacteriaceae. Med Mal Infect 45:169–172

    Article  Google Scholar 

  • Eshetie S, Unakal C, Gelaw A, Ayelign B, Endris M, Moges F (2015) Multidrug resistant and carbapenemase producing Enterobacteriaceae among patients with urinary tract infection at referral hospital, Northwest Ethiopia. Antimicrob Resist Infect Control 4:12

    Article  Google Scholar 

  • Fernando M, Luke W, Miththinda J, Wickramasinghe R, Sebastiampillai B, Gunathilake M, Silva F, Premaratna R (2017) Extended spectrum beta lactamase producing organisms causing urinary tract infections in Sri Lanka and their antibiotic susceptibility pattern – a hospital based cross sectional study. BMC Infect Dis 17:138

    Article  CAS  Google Scholar 

  • Flateau C, Duron-Martinaud S, Haus-Cheymol R, Bousquet A, Delaune D, Ficko C, Merens A, Rapp C (2018) Prevalence and risk factors for extended-spectrum beta-lactamase-producing-Enterobacteriaceae in French military and civilian travelers: a cross-sectional analysis. Travel Med Infect Dis 23:44–48

    Article  Google Scholar 

  • Flokas ME, Karanika S, Alevizakos M, Mylonakis E (2017) Prevalence of ESBL-producing Enterobacteriaceae in pediatric bloodstream infections: a systematic review and meta-analysis. PLoS One 12:e0171216

    Article  Google Scholar 

  • Gajdács M (2019) The concept of an ideal antibiotic: implications for drug design. Molecules 24:892

    Article  Google Scholar 

  • Gajdács M (2020) The importance of reporting clinical and epidemiological data in urology: local experiences and insights from the international literature. Medicina 56:581

    Article  Google Scholar 

  • Gajdács M, Ábrók M, Lázár A, Burián K (2019) Comparative epidemiology and resistance trends of common urinary pathogens in a tertiary-care hospital: a 10-year surveillance study. Medicina 55:356

    Article  Google Scholar 

  • Gajdács M, Ábrók M, Lázár A, Jánvári L, Tóth Á, Terhes G, Burián K (2020a) Detection of VIM, NDM and OXA-48 producing carbapenem resistant Enterobacterales among clinical isolates in southern Hungary. Acta Microbiol Immunol Hung 67:209–215

    Article  Google Scholar 

  • Gajdács M, Bátori Z, Ábrók M, Lázár A, Burián K (2020b) Characterization of resistance in gram-negative urinary isolates using existing and novel indicators of clinical relevance: a 10-year data analysis. Life 10:16

    Article  Google Scholar 

  • Gashaw M, Berhane M, Bekele S, Kibru G, Teshager L, Yilma Y, Ahmed Y, Fentahun N, Assefa H, Wieser A (2018) Emergence of high drug resistant bacterial isolates from patients with health care associated infections at Jimma University medical center: a cross sectional study. Antimicrob Resist Infecti Control 7:138

    Article  Google Scholar 

  • Hassan H, Abdalhamid B (2014) Molecular characterization of extended-spectrum beta-lactamase producing Enterobacteriaceae in a Saudi Arabian tertiary hospital. J Infect Dev Ctries 8:282–288

    Article  Google Scholar 

  • Kiddee A, Assawatheptawee K, Na-Udom A, Boonsawang P, Treebupachatsakul P, Walsh TR, Niumsup PR (2019) Risk factors for extended-spectrum β-lactamase-producing Enterobacteriaceae carriage in patients admitted to intensive care unit in a tertiary care hospital in Thailand. Microb Drug Resist 25:1182–1190

    Article  CAS  Google Scholar 

  • Legese MH, Weldearegay GM, Asrat D (2017) Extended-spectrum beta-lactamase-and carbapenemase-producing Enterobacteriaceae among Ethiopian children. Infect Drug Resist 10:27

    Article  CAS  Google Scholar 

  • Nakai H, Hagihara M, Kato H, Hirai J, Nishiyama N, Koizumi Y, Sakanashi D, Suematsu H, Yamagishi Y, Mikamo H (2016) Prevalence and risk factors of infections caused by extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. J Infect Chemother 22:319–326

    Article  CAS  Google Scholar 

  • Okoche D, Asiimwe BB, Katabazi FA, Kato L, Najjuka CF (2015) Prevalence and characterization of carbapenem-resistant Enterobacteriaceae isolated from Mulago National Referral Hospital, Uganda. PLoS One 10:e0135745

    Article  Google Scholar 

  • Ouedraogo AS, Sanou M, Kissou A, Sanou S, Solare H, Kabore F, Poda A, Aberkane S, Bouzinbi N, Sano I, Nacro B, Sangare L, Carriere C, Decre D, Ouegraogo R, Jean-Pierre H, Godreuil S (2016) High prevalence of extended-spectrum ss-lactamase producing enterobacteriaceae among clinical isolates in Burkina Faso. BMC Infect Dis 16:326

    Article  Google Scholar 

  • Pishtiwan AH, Khadija KM (2019) Prevalence of blaTEM, blaSHV, and blaCTX-M genes among ESBL-producing Klebsiella pneumoniae and Escherichia coli isolated from thalassemia patients in Erbil, , Iraq. Mediterr J Hematol Infect Dis 11:e2019041

    Article  Google Scholar 

  • Rao MR, Chandrashaker P, Mahale RP, Shivappa SG, Gowda RS, Chitharagi VB (2019) Detection of carbapenemase production in Enterobacteriaceae and pseudomonas species by carbapenemase Nordmann–Poirel test. J Lab Phys 11:107

    CAS  Google Scholar 

  • Reuland E, Al Naiemi N, Kaiser A, Heck M, Kluytmans J, Savelkoul P, Elders P, Vandenbroucke-Grauls C (2016) Prevalence and risk factors for carriage of ESBL-producing Enterobacteriaceae in Amsterdam. J Antimicrob Chemother 71:1076–1082

    Article  CAS  Google Scholar 

  • Rodríguez-Baño J, Gutiérrez-Gutiérrez B, Machuca I, Pascual A (2018) Treatment of infections caused by extended-spectrum-beta-lactamase-, AmpC-, and carbapenemase-producing. Enterobacteriaceae CMR 31(2):e00079–e00017

    Google Scholar 

  • Saliu EM, Vahjen W, Zentek J (2017) Types and prevalence of extended-spectrum beta-lactamase producing Enterobacteriaceae in poultry. Anim Health Res Rev 18:46–57

    Article  Google Scholar 

  • Selassie LG (2016) Prevalence of extended spectrum beta-lactamase producing Enterobacteriaceae: a cross sectional study at Adama Hospital, Adama, Ethiopia. J Emerg Infect Dis 1:102

    Google Scholar 

  • Singh N, Pattnaik D, Neogi DK, Jena J, Mallick B (2016) Prevalence of ESBL in Escherichia coli isolates among ICU patients in a tertiary care hospital. J Clin Diagn Res 10:DC19–DC22

    PubMed  PubMed Central  Google Scholar 

  • Tamadonfar KO, Omattage NS, Spaulding CN, Hultgren SJ (2019) Reaching the end of the line: urinary tract infections. Bacteria Intracellularity 7(3): 83–99

    Google Scholar 

  • Teklu DS, Negeri AA, Legese MH, Bedada TL, Woldemariam HK, Tullu KD (2019) Extended-spectrum beta-lactamase production and multi-drug resistance among Enterobacteriaceae isolated in Addis Ababa, Ethiopia. Antimicrob Resist Infect Control 8:39

    Article  Google Scholar 

  • Vandepitte J, Verhaegen J, Engbaek K, Rohner P, Piot P, Heuck C, Heuck C (2003) Basic laboratory procedures in clinical bacteriology. World Health Organization, Geneva

    Google Scholar 

  • Woodford N, Xu-Mccrae L, Mushtaq S, Wu HHT, Ellington MJ, Lancaster O, Davies F, Donaldson H, Rao GG, Verma A (2018) Prevalence of carbapenem resistance and carbapenemase production among Enterobacteriaceae isolated from urine in the UK: results of the UK infection-Carbapenem Resistance Evaluation Surveillance Trial (iCREST-UK). J Antimicrob Chemother 73:698–702

    Article  CAS  Google Scholar 

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Acknowledgments

The authors would like to thank TASH laboratory staffs for their well coming approach during the laboratory work and the study participants.

Author Contributions

All authors made a significant contribution to the work reported, Data acquisition, analysis and interpretation: SS and TA. Revising critically and Final approval: BY, AA, DA, TA and AM. All authors gave final approval of the version to be published

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The datasets supporting the conclusions of this article are included within the article and its additional files

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Correspondence to Aminu Seman .

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Seman, A. et al. (2021). The Magnitude of Carbapenemase and ESBL Producing Enterobacteriaceae Isolates from Patients with Urinary Tract Infections at Tikur Anbessa Specialized Teaching Hospital, Addis Ababa, Ethiopia. In: Donelli, G. (eds) Advances in Microbiology, Infectious Diseases and Public Health. Advances in Experimental Medicine and Biology(), vol 1369. Springer, Cham. https://doi.org/10.1007/5584_2021_687

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