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In Vivo and In Vitro Models of Diabetes: A Focus on Pregnancy

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Diabetes: from Research to Clinical Practice

Part of the book series: Advances in Experimental Medicine and Biology ((AIM,volume 1307))

Abstract

Diabetes in pregnancy is associated with an increased risk of poor outcomes, both for the mother and her offspring. Although clinical and epidemiological studies are invaluable to assess these outcomes and the effectiveness of potential treatments, there are certain ethical and practical limitations to what can be assessed in human studies.

Thus, both in vivo and in vitro models can aid us in the understanding of the mechanisms behind these complications and, in the long run, towards their prevention and treatment. This review summarizes the existing animal and cell models used to mimic diabetes, with a specific focus on the intrauterine environment.

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Summary of this review

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Authors and Affiliations

  1. Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Islas Canarias, Spain

    Joaquín Lilao-Garzón, Carmen Valverde-Tercedor, Silvia Muñoz-Descalzo, Yeray Brito-Casillas & Ana M. Wägner

  2. Servicio de Endocrinología y Nutrición, Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, Las Palmas de Gran Canaria, Spain

    Ana M. Wägner

Authors
  1. Joaquín Lilao-Garzón
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  2. Carmen Valverde-Tercedor
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  3. Silvia Muñoz-Descalzo
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  4. Yeray Brito-Casillas
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  5. Ana M. Wägner
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Corresponding author

Correspondence to Yeray Brito-Casillas .

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Editors and Affiliations

  1. Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden, Department of Emergency Care and Internal Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden

    Md. Shahidul Islam

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Lilao-Garzón, J., Valverde-Tercedor, C., Muñoz-Descalzo, S., Brito-Casillas, Y., Wägner, A.M. (2020). In Vivo and In Vitro Models of Diabetes: A Focus on Pregnancy. In: Islam, M.S. (eds) Diabetes: from Research to Clinical Practice. Advances in Experimental Medicine and Biology(), vol 1307. Springer, Cham. https://doi.org/10.1007/5584_2020_536

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  • DOI: https://doi.org/10.1007/5584_2020_536

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