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Multistage Magnetic and Electrophoretic Extraction of Cells, Particles and Macromolecules

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New Products and New Areas of Bioprocess Engineering

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 68))

Abstract

Improved techniques for separating cells, particles, and macromolecules (proteins) are increasingly important to biotechnology because separation is frequently the limiting factor for many biological processes. Manufacturers of new enzymes and pharmaceutical products require improved methods for recovering intact cells and intracellular products. Similarly isolation, purification, and concentration of many biomolecules produced in fermentation processes is extremely important. Often such downstream processing contributes a large portion of the product cost. In conventional methods like centrifugation and even modern methods like chromatography, scale-up problems are enormous, making them uneconomical and prohibitively expensive unless the product is of very high value. Therefore there has been a need for efficient and economical alternative approaches to bioseparation processes to eliminate, reduce, or facilitate solids handling. Magnetic and electric field assisted separations may hold considerable potential for providing a future major improvement in bioseparation technology.

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Authors and Affiliations

  1. Department of Food Engineering, Central Food Technological Research Institute (CFTRI), Mysore, 570 013, India

    K. S. M. S. Raghavarao

  2. Department of Chemical Engineering, University of Colorado, Boulder, CO, 80809-424, USA

    Marc Dueser & Paul Todd

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  1. K. S. M. S. Raghavarao
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Raghavarao, K.S.M.S., Dueser, M., Todd, P. (2000). Multistage Magnetic and Electrophoretic Extraction of Cells, Particles and Macromolecules. In: New Products and New Areas of Bioprocess Engineering. Advances in Biochemical Engineering/Biotechnology, vol 68. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45564-7_4

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