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Ganglioside galactosyltransferase

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Class 2 · Transferases IV

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume 31))

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References

  1. Sanyal, S.N.: Stimulation of uridine diphosphate-galactose: ceramide galactosyl transferase by certain soluble protein factor in rat brain cytosol. Indian J. Exp. Biol., 25, 606–612 (1987)

    PubMed  CAS  Google Scholar 

  2. Neskovic, N.M.; Mandel, P.; Gatt, S.: UDP-galactose: ceramide galactosyltransferase. Kinetic properties and effect of detergents and phospholipids on the partially purified enzyme of rat brain. Adv. Exp. Med. Biol., 101, 613–630 (1978)

    PubMed  CAS  Google Scholar 

  3. Basu, S.; Kaufman, B.; Roseman, S.: Conversion of Tay-Sachs ganglioside to monosialoganglioside by brain uridine diphosphate d-galactose: glycolipid galactosyltransferase. J. Biol. Chem., 240, 4115–4117 (1965)

    PubMed  CAS  Google Scholar 

  4. Yip, M.C.M.; Dain, J.A.: Frog brain uridine diphosphate galactose-N-acetyl-galactosaminyl-N-acetylneuraminylgalactosylglucosylceramide galactosyltransferase. Biochem. J., 118, 247–252 (1970)

    PubMed  CAS  Google Scholar 

  5. Bellman Yip, G.; Dain, J.A.: The enzymic synthesis of ganglioside. II. UDPgalactose: N-acetylgalactosaminyl-(n-acetylneuraminyl)galactosyl-glucosylceramide galactosyltransferase in rat brain. Biochim. Biophys. Acta, 206, 252–260 (1970)

    Google Scholar 

  6. Senn, H.J.; Wagner, M.; Decker, K.: Ganglioside biosynthesis in rat liver. Characterization of UDPgalactose-glucosylceramide galactosyltransferase and UDPgalactose-GM2 galactosyltransferase. Eur. J. Biochem., 135, 231–236 (1983)

    Article  PubMed  CAS  Google Scholar 

  7. Costantino-Ceccarini, E.; Suzuki, K.: Isolation and partial characterization of an endogenous inhibitor of ceramide glycosyltransferases from rat brain. J. Biol. Chem., 253, 340–342 (1978)

    PubMed  CAS  Google Scholar 

  8. Stahl, N.; Jurevics, H.; Morell, E; Suzuki, K.; Popko, B.: Isolation, characterization, and expression of cDNA clones that encode rat UDP-galactose:ceramide galactosyltransferase. J. Neurosci. Res., 38, 234–242 (1994)

    Article  PubMed  CAS  Google Scholar 

  9. Schulte, S.; Stoffel, W.: UDP galactose:ceramide galactosyltransferase and glutamate/aspartate transporter. Copurification, separation and characterization of the two glycoproteins. Eur. J. Biochem., 233, 947–953 (1995)

    Article  PubMed  CAS  Google Scholar 

  10. Ghosh, S.; Kyle, J.W.; Dastgheib, S.; Daussin, E; Li, Z.; Basu, S.: Purification, properties, and immunological characterization of GalT-3 (UDP-galactose: GM2 ganglioside, β1-3 galactosyltransferase) from embryonic chicken brain. Glycoconjugate J., 12, 838–847 (1995)

    Article  CAS  Google Scholar 

  11. Sprong, H.; Kruithof, B.; Leijendekker, R.; Slot, J.W.; Van Meer, G.; Van Der Sluijs, E: UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum. J. Biol. Chem., 273, 25880–25888 (1998)

    Article  PubMed  CAS  Google Scholar 

  12. Amado, M.; Almeida, R.; Carneiro, E; Levery, S.B.; Holmes, E.H.; Nomoto, M.; Hollingsworth, M.A.; Hassan, H.; Schwientek, T.; Nielsen, EA.; Bennett, E.E; Clausen, H.: A family of human β3-galactosyltransferases. Characterization of four members of a UDP-galactose:β-N-acetyl-glucosamine/β-acetyl-galactosamine β-1,3-galactosyltransferase family. J. Biol. Chem., 273, 12770–12778 (1998)

    Article  PubMed  CAS  Google Scholar 

  13. Daniotti, J.L.; Martina, J.A.; Zurita, A.R.; Maccioni, H.J.: Mouse β 1,3-galactosyltransferase (GAI/GMI/GDlb synthase): protein characterization, tissue expression, and developmental regulation in neural retina. J. Neurosci. Res., 58, 318–327 (1999)

    Article  PubMed  CAS  Google Scholar 

  14. Martina, J.A.; Daniotti, J.L.; Maccioni, H.J.: GM1 synthase depends on N-glycosylation for enzyme activity and trafficking to the Golgi complex. Neurochem. Res., 25, 725–731 (2000)

    Article  PubMed  CAS  Google Scholar 

  15. Tencomnao, T.; Yu, R.K.; Kapitonov, D.: Characterization of the human UDP-galactose:ceramide galactosyltransferase gene promoter. Biochim. Biophys. Acta, 1517, 416–423 (2001)

    PubMed  CAS  Google Scholar 

  16. Paul, E; Lutz, T.M.; Osborn, C.; Kyosseva, S.; Elbein, A.D.; Towbin, H.; Radominska, A.; Drake, R.R.: Synthesis and characterization of a new class of inhibitors of membrane-associated UDP-glycosyltransferases. J. Biol. Chem., 268, 12933–12938 (1993)

    PubMed  CAS  Google Scholar 

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(2006). Ganglioside galactosyltransferase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Class 2 · Transferases IV. Springer Handbook of Enzymes, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-37718-2_62

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