Zusammenfassung
Der Morbus Whipple (M. Whipple) ist eine systemische bakterielle Krankheit, die hauptsächlich die männliche weiße Bevölkerung im mittleren Lebensalter betrifft, mit Befall des Darms und seiner Lymphabflusswege, des Herzens, der Gelenke sowie des Zentralnervensystems (ZNS). Sie ist durch folgende Symptome gekennzeichnet: Arthralgien, Durchfälle, abdominelle Schmerzen, Gewichtsverlust. Weitere häufige Symptome sind: Lymphadenopathie, Fieber, verstärkte Pigmentierung der Haut. Die Gewebe zeigen eine Infiltration mit Makrophagen, die sich intensiv PAS-positiv anfärben.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
Literatur
Caspary WF, Stein J (Hrsg) (1999) Darmkrankheiten. Springer, Berlin Heidelberg
Chears WCJ, Ashworth CT (1961) Electron microscopic study of the intestinal mucosa in Whipple’s disease: demonstration of encapsulated bacilliform bodies in the lesion. Gastroenterology 41: 129–138
Cohen AS, Schimmel EM, Holt PR, Isselbacher KJ (1960) Ultrastructural abnormalities in Whipple’s disease. Proc Soc Exp Biol Med 105: 411–415
Cohen L, Berthet K, Cauga D et al. (1996) Polymerase chain reaction of cerebrospinal fluid to diagnose Whipple’s disease [letter]. Lancet 347: 329
Cooper GS, Blades EW, Remler BF, Salata RA, Bennert KW, Jacobs GH (1994) Central nervous system Whipple’s disease: relapse during therapy with trimethoprim-sulfamethoxazone and remission with cefixime. Gastroenterology 106: 782–786
Dobbins WO III (1987) Whipple’s disease. Springfield, Ill.: Charles C Thomas
Dobbins WO III, Kawanishi H (1981) Bacillary characteristics in Whipple’s disease: an electronmicroscopic study. Gastroenterology 80: 1468–1474
Donaldson RM (1992) Whipple’s disease — rare malady with uncommon potential. New Engl J Med 327: 346–348
Ehrbar HU, Bauernfeind P, Dutley F et al. (1999) PCR-positive tests for Tropheryma whippelii in patients without Whipple’s disease [Letter]. Lancet 353: 2214
Feurle GE, Volk B, Waldherr R (1979) Cerebral Whipple’s disease with negative jejunal histology. New Engl J Med 300: 907–908
Feurle GE, Marth T (1994) An evaluation of antimicrobial treatment for Whipple’s disease. Dig Dis Sci 39: 1642–1646
Herbay A von, Ditton H, Maiwald M (1996) Diagnostic application of a polymerase chain reaction assay for the Whipple’s disease bacterium to intestinal biopsies. Gastroenterology 110: 1735–1743
Herbay A von, Maiwald M, Ditton H-J, Otto HF (1996) Histology of intestinal Whipple’s disease revisited. A study of 48 patients. Virchows Arch 429: 335–343
Herbay A von, Ditton H-J, Schuhmacher F, Maiwald M (1997) Whipple’s disease: staging and monitoring by cytology and polymerase chain reaction analysis of cerebrospinal fluid. Gastroenterology 113: 434–441
Herbay A von, Otto HF, Stolte M, Borchard, F, Ditton H-J, Maiwald M (1997) Epidemiology of Whipple’s disease in Germany. Analysis of 110 patients diagnosed in 1965–1995. Scand J Gastroenterol 32: 52–57
Keinath RD, Merrell DE, Vlietstra R, Dobbins WO III (1985) Antibiotic treatment and relapse in Whipple’s disease. Long-term follow-up of 88 patients. Gastroenterology 88: 1867–1873
Louis ED, Lynch T, Kaufmann P et al. (1996) Diagnostic guidelines in central nervous system Whipple’s disease. Ann Neurol 40: 561–566
Lowsky R, Archer GL, Fyles G et al. (1994) Diagnosis of Whipple’s disease by molecular analysis of peripheral blood. New Engl J Med. 331: 1343–1346
Marth T, Neurath M, Cuccherini BA, Strober W (1997) Defects of monocyte interleukin 12 production and humoral immunity in Whipple’s disease. Gastroenterology 113: 442–448
Müller C, Petermann D, Stain C et al. (1997) Whipple’s disease: comparison of histology with diagnosis based on polymerase chain reaction in four consecutive cases. Gut 40: 425–427
Ramzan NN, Loftus E jr, Burgart LJ et al. (1997) Diagnosis and monitoring of Whipple’s disease by polymerase chain reaction. Ann Intern Med 126: 520–524
Raoult D, Birg ML, La Scola B et al. (2000) Cultivation of the bacillus of Whipple’s disease. New Engl J Med 342: 620–625
Relman DA, Schmidt TM, MacDermott RP, Falkow S (1992) Identification of the uncultered bacillus of Whipple’s disease. New Engl J Med 327: 293–301
Ryser RJ, Locksley RM, Eng SC, Dobbins WO III, Schoenknecht FD, Rubin CE (1984) Reversal of dementia associated with Whipple’s disease by trimethoprim-sulfametoxazole, drugs that penetrate the blood-brain barrier. Gastroenterology 86: 745–752
Schnider PJ, Reisinger EC, Gerschlager W et al. (1996) Long-term follow-up in cerebral Whipple’s disease. Europ J Gastroenterol Hepatol 8: 899–903
Swartz MN (2000) Whipple’s disease — past, present, and future [editorial]. New Engl J Med 342: 648–649
Whipple GH (1907) A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissue. Bull Johns Hopkins Hosp 18: 382–391
Wilson KH, Blitchington R, Frothingham R, Wilson JAP (1991) Phylogeny of the Whipple’s-disease-associated bacterium. Lancet 338: 474–475
Yardley JH, Hendrix TR (1961) Combined electron and light microscopy in Whipple’s disease: demonstration of »bacillary bodies« in the intestine. Bull Johns Hopkins Hosp 109: 80–98
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer Medizin Verlag Heidelberg
About this chapter
Cite this chapter
von Arnim, U., Caspary, W.F. (2006). Morbus Whipple. In: Caspary, W.F., Kist, M., Stein, J. (eds) Infektiologie des Gastrointestinaltraktes. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-37211-3_21
Download citation
DOI: https://doi.org/10.1007/3-540-37211-3_21
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-41359-2
Online ISBN: 978-3-540-37211-0
eBook Packages: Medicine (German Language)