Skip to main content
SpringerLink
Log in

Early and Late Treatment-Induced Toxicity

  • Chapter
Multimodal Concepts for Integration of Cytotoxic Drugs

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Andreassen CN, Grau C, Lindegaard JC (2003) Chemical radioprotection: a critical review of amifostine as a cytoprotector in radiotherapy. Semin Radiat Oncol 13:62–72

    Article  PubMed  Google Scholar 

  • Antonadou D, Pepelassi M, Synodinou M et al. (2002) Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer. Int J Radiat Oncol Biol Phys 52:739–747

    Article  PubMed  CAS  Google Scholar 

  • Antonadou D, Throuvalas N, Petridis A et al (2003) Effect of amifostine on toxicities associated with radiochemotherapy in patients with locally advanced non-small cell lung cancer. Int J Radiat Oncol Biol Phys 57:402–408

    Article  PubMed  CAS  Google Scholar 

  • Athanassiou H, Antonadou D, Coliarakis N et al. (2003) Protective effect of amifostine during fractionated radiotherapy in patients with pelvic carcinomas: results of a randomized trial. Int J Radiat Oncol Biol Phys 56:1154–1160

    Article  PubMed  CAS  Google Scholar 

  • Badger C, Preston N, Seers K et al. (2004) Physical therapies for reducing and controlling lymphoedema of the limbs. Cochrane Database Syst Rev 18:CD003141

    Google Scholar 

  • Bairati I, Meyer F, Gelinas M et al. (2005) Randomized trial of antioxidant vitamins to prevent acute adverse effects of radiation therapy in head and neck cancer patients. J Clin Oncol 23:5805–5813

    Article  PubMed  CAS  Google Scholar 

  • Baughan CA, Canney PA, Buchanan RB et al. (1993) A randomized trial to assess the efficacy of 5-aminosalicylic acid for the prevention of radiation enteritis. Clin Oncol (R Coll Radiol) 5:19–24

    CAS  Google Scholar 

  • Belderbos J, Heemsbergen W, Hoogeman M et al. (2005) Acute esophageal toxicity in non-small cell lung cancer patients after high dose conformal radiotherapy. Radiother Oncol 75:157–164

    Article  PubMed  Google Scholar 

  • Brizel DM, Wasserman TH, Henke M et al. (2000) Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. J Clin Oncol 18:3339–3345. Erratum in: J Clin Oncol 18:4110–4111

    PubMed  CAS  Google Scholar 

  • Bourhis J. Crevoisier R de, Abdulkarim B et al. (2000) A randomized study of very accelerated radiotherapy with and without amifostine in head and neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys 46:1105–1108

    Article  PubMed  CAS  Google Scholar 

  • Bourhis J, Rosine D (2002) Radioprotective effect of amifostine in patients with head and neck squamous cell carcinoma. Semin Oncol 29(Suppl 19):61–62

    Article  PubMed  Google Scholar 

  • Bourhis J, Thephamongkhol K, Pignon JP (2004) Randomized trials of amifostine and radiotherapy: Effect on survival? Semin Oncol 6Suppl 18:62–66

    Article  CAS  Google Scholar 

  • Breccia A, Badiello R, Trenta A et al. (1969) On the chemical radioprotection by organic selenium compounds in vivo. Radiat Res 38:483–492

    PubMed  CAS  Google Scholar 

  • Bruns F, Micke O, Bremer M (2003) Current status of selenium and other treatments for secondary lymphedema. J Support Oncol 1:121–130

    PubMed  CAS  Google Scholar 

  • Bruns F, Buentzel J, Muecke R et al. (2004) Selenium in the treatment of head and neck lymphedema. Med Princ Pract 13:185–190

    Article  PubMed  CAS  Google Scholar 

  • Buentzel J, Micke O, Adamietz IA et al. (2005) Intravenous amifostine during chemoradiotherapy for head-and-neck cancer: a randomized placebo-controlled phase III study. Int J Radiat Oncol Biol Phys epub

    Google Scholar 

  • Burger A, Löffler H, Bamberg M et al. (1998) Molecular and cellular basis of radiation fibrosis. Int J Radiat Biol 73:401–408

    Article  PubMed  CAS  Google Scholar 

  • Burtness B (2005) The role of cetuximab in the treatment of squamous cell cancer of the head and neck. Expert Opin Biol Ther 5:1085–1093

    Article  PubMed  CAS  Google Scholar 

  • Campbell BH, Spinelli K, Marbella AM et al. (2004) Aspiration, weight loss, and quality of life in head and neck cancer survivors. Arch Otolaryngol Head Neck Surg 130:1100–1103

    Article  PubMed  Google Scholar 

  • Carpenter M, Epperly MW, Agarwal A et al. (2005) Inhalation delivery of manganese superoxide dismutase-plasmid/liposomes protects the murine lung from irradiation damage. Gene Ther 12:685–693

    Article  PubMed  CAS  Google Scholar 

  • Cassatt DR, Fazenbaker CA, Kifle G et al. (2003a) Effects of dose and schedule on the efficacy of ethyol: preclinical studies. Semin Oncol 30(Suppl) 18:31–39

    Article  PubMed  CAS  Google Scholar 

  • Cassatt DR, Fazenbaker CA, Kifle G et al. (2003b) Subcutaneous administration of amifostine (ethyol) is equivalent to intravenous administration in a rat mucositis model. Int J Radiat Oncol Biol Phys 57:794–802

    Article  PubMed  CAS  Google Scholar 

  • Cassatt DR, Fazenbaker CA, Bachy CM et al. (2005) Amifostine (ETHYOL) protects rats from mucositis resulting from fractionated or hyperfractionated radiation exposure. Int J Radiat Oncol Biol Phys 61:901–907

    Article  PubMed  CAS  Google Scholar 

  • Cheville AL, McGarvey CL, Petrek JA et al. (2003) Lymphedema management. Semin Radiat Oncol 13:290–301

    Article  PubMed  Google Scholar 

  • Claude L, Perol D, Ginestet C et al. (2004) A prospective study on radiation pneumonitis following conformal radiation therapy in non-small-cell lung cancer: clinical and dosimetric factors analysis. Radiother Oncol 71:175–181

    Article  PubMed  Google Scholar 

  • Coppes RP, Wierenga PK, Lombaert I et al. (2005) Mobilisation of bone marrow-derived stem cells reduces radiation-induced damage to salivary glands (Abstract). Molec Radiat Biol Oncol 6:100

    Google Scholar 

  • Cotrim AP, Sowers AL, Lodde BM et al. (2005) Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model. Clin Cancer Res 11:7564–7568

    Article  PubMed  CAS  Google Scholar 

  • Delanian S, Porcher R, Rudant J et al. (2005) Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis. J Clin Oncol 23:8570–8579

    Article  PubMed  Google Scholar 

  • Demark-Wahnefried W, Aziz NM, Rowland JH et al. (2005) Riding the crest of the teachable moment: promoting long-term health after the diagnosis of cancer. J Clin Oncol 23:5814–5830

    Article  PubMed  Google Scholar 

  • Dittmann K, Toulany M, Classen J et al. (2005) Selective radioprotection of normal tissues by Bowman-Birk proteinase inhibitor (BBI) in mice. Strahlenther Onkol 181:191–196

    Article  PubMed  Google Scholar 

  • Dörr W (1997) Three A’s of repopulation during fractionated irradiation in squamous epithelia: Asymmetry loss, Acceleration of stem-cell divisions and Abortive divisions. Int J Radiat Biol 72:635–643

    Article  PubMed  Google Scholar 

  • Dörr W (1998) Radiobiological models of normal tissue responses. Strahlenther Onkol 174(Suppl III):4–7

    PubMed  Google Scholar 

  • Dörr W (2003a) Modulation of repopulation processes in oral mucosa: experimental results. Int J Radiat Biol 79:531–537

    Article  PubMed  Google Scholar 

  • Dörr W (2003b) Oral mucosa: response modification by keratinocyte growth factor. In: Nieder C, Milas L, Ang KK (eds) Biological modification of radiation response. Springer, Berlin Heidelberg New York, pp 113–122

    Google Scholar 

  • Dörr W, Kummermehr J (1992) Increased radiation tolerance of mouse tongue epithelium after local conditioning. Int J Radiat Biol 61:369–379

    PubMed  Google Scholar 

  • Dörr W, Hendry JH (2001) Consequential late effects in normal tissues. Radiother Oncol 61:223–231

    Article  PubMed  Google Scholar 

  • Dörr W, Herrmann T (2003) Pathogenetic mechanisms of lung fibrosis. In: Nieder C, Milas L, Ang KK (eds) Biological modification of radiation response. Springer, Berlin Heidelberg New York, pp 29–36

    Google Scholar 

  • Dörr W, Gehrisch A (2005) Modification of oral mucositis by local or systemic administration of selenium: experimental studies in mice (Abstract). Supp Care Cancer 13:442

    Google Scholar 

  • Dörr W, Jakubec A, Kummermehr J et al. (1995) Effects of stimulated repopulation on oral mucositis during conventional radiotherapy. Radiother Oncol 37:100–107

    Article  PubMed  Google Scholar 

  • Dörr W, Eckhardt M, Ehme A et al. (1998) Pathogenesis of the acute radiation response of the urinary bladder: experimental results. Strahlenther Onkol 174(Suppl III):93–95

    PubMed  Google Scholar 

  • Dörr W, Krumsdorf D, Noack R (2000) Amelioration of late radiation effects in mouse urinary bladder by modulation of acute symptoms: experimental evidence for consequential late effects. Radiother Oncol 57(Suppl 1):S37–S39

    Google Scholar 

  • Dörr W, Noack R, Spekl K et al. (2001) Modification of oral mucositis by keratinocyte growth factor: single radiation exposure. Int J Radiat Biol 77:341–347

    Article  PubMed  Google Scholar 

  • Dörr W, Spekl K, Farrell CL (2002) Amelioration of acute oral mucositis by keratinocyte growth factor: fractionated irradiation. Int J Radiat Oncol Biol Phys 54:245–251

    Article  PubMed  Google Scholar 

  • Dörr W, Reichel S, Spekl K (2005a) Effects of keratinocyte growth factor (palifermin) administration protocols on oral mucositis (mouse) induced by fractionated irradiation. Radiother Oncol 75:99–105

    Article  PubMed  CAS  Google Scholar 

  • Dörr W, Bässler S, Reichel S et al. (2005b) Reduction of radiochemotherapy-induced early oral mucositis by recombinant human keratinocyte growth factor (KGF): experimental studies in mice. Int J Radiat Oncol Biol Phys 62:881–88

    Article  PubMed  CAS  Google Scholar 

  • Dörr W, Gabriel P, Siegemund A et al. (2005c) Modification of oral mucositis (mouse) by treatment with adult stem cells (Abstract). Supp Care Cancer 13:441

    Google Scholar 

  • Dörr W, Gabriel P, Siegemund A et al. (2005d) Modification of radiation effects in oral mucosa (mouse) by adult stem cells (Abstract). Molec Radiat Biol Oncol 6:91

    Google Scholar 

  • Dörr W, Heider K, Spekl K (2005e) Reduction of oral mucositis by palifermin (rHuKGF): dose effect of rHuKGF. Int J Radiat Biol 81:557–565

    Article  PubMed  CAS  Google Scholar 

  • Duke RL, Campbell BH, Indresano AT et al. (2005) Dental status and quality of life in long-term head and neck cancer survivors. Laryngoscope 115:678–683

    PubMed  Google Scholar 

  • El-Sayed S, Nabid A, Shelley W et al. (2002) Prophylaxis of radiation-induced mucositis in conventionally treated patients with head and neck cancer: a double-blind, phase III, randomized, controlled trial evaluating the clinical efficacy of an antimicrobial lozenge using a validated mucositis scoring system. J Clin Oncol 20:3956–3963

    Article  PubMed  CAS  Google Scholar 

  • Epperly MW, Carpenter M, Agarwal A et al. (2004) Intraoral manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis. In Vivo 18:401–410

    PubMed  CAS  Google Scholar 

  • Ertekin MV, Koc M, Karslioglu I et al. (2004) Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study. Int J Radiat Oncol Biol Phys 58:167–174

    Article  PubMed  CAS  Google Scholar 

  • Fajardo LF, Berthrong M, Anderson RE (2001) Radiation pathology. Oxford University Press, Oxford, pp 337–346

    Google Scholar 

  • Fehrmann A, Dörr W (2005) Effect of EGFR-inhibition on the radiation response of oral mucosa: experimental studies in mouse tongue epithelium. Int J Radiat Biol 81:437–443

    PubMed  CAS  Google Scholar 

  • Ferreira PR, Fleck JF, Diehl A et al. (2004) Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: a double-blind randomized trial. Head Neck 26:313–321

    Article  PubMed  Google Scholar 

  • Food and Drug Administration (FDA) (2004) Palifermin (keratinocyte growth factor). www.fda.gov/cder/drug/infopage/palifermin/default.htm. Status 15.12.2004

    Google Scholar 

  • Ganser A, Karthaus M (1996) Clinical use of hematopoietic growth factors. Curr Opin Oncol 8:265–269

    Article  PubMed  CAS  Google Scholar 

  • Ginsberg JP, Womer RB (2005) Preventing organ-specific chemotherapy toxicity. Eur J Cancer 41:2690–2700

    Article  PubMed  Google Scholar 

  • Gottlober P, Steinert M, Bahren W et al. (2001) Interferon-gamma in 5 patients with cutaneous radiation syndrome after radiation therapy. Int J Radiat Oncol Biol Phys 50:159–166

    Article  PubMed  CAS  Google Scholar 

  • Graham MV, Purdy JA, Emami B et al. (1999) Clinical dosevolume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys 45:323–329

    Article  PubMed  CAS  Google Scholar 

  • Grdina DJ, Murley JS, Kataoka Y (2002) Radioprotectants: current status and new directions. Oncology 63(Suppl 2):2–10

    Article  PubMed  CAS  Google Scholar 

  • Haddad R, Wirth L, Costello R et al. (2003) Phase II randomized study of concomitant chemoradiation using weekly carboplatin/paclitaxel with or without daily subcutaneous amifostine in patients with newly diagnosed locally advanced squamous cell carcinoma of the head and neck. Semin Oncol 30(Suppl 18):84–88

    Article  PubMed  CAS  Google Scholar 

  • Hakenjos L, Bamberg M, Rodemann HP (2000) TGFß mediated alterations of rat lung fibroblast differentiation resulting in the radiation-induced fibrotic phenotype. Int J Radiat Biol 76:503–509

    Article  PubMed  CAS  Google Scholar 

  • Heflin LH, Meyerowitz BE, Hall P et al. (2005) Cancer as a risk factor for long-term cognitive deficits and dementia. J Natl Cancer Inst 97:854–856

    Article  PubMed  Google Scholar 

  • Hegazy MA, Fowler JF (1973) Cell population kinetics and desquamation reactions in plucked and unplucked mouse skin. II. Irradiated skin. Cell Tissue Kinet 6:587–602

    PubMed  CAS  Google Scholar 

  • Hernando ML, Marks LB, Bentel GC et al. (2001) Radiationinduced pulmonary toxicity: a dose-volume histogram analysis in 201 patients with lung cancer. Int J Radiat Oncol Biol Phys 51:650–659

    Article  PubMed  CAS  Google Scholar 

  • Hille A, Christiansen H, Pradier O et al. (2005) Effect of pentoxifylline and tocopherol on radiation proctitis/enteritis. Strahlenther Onkol 181:606–614

    Article  PubMed  Google Scholar 

  • Holthusen H (1936) Erfahrungen über die Verträglichkeitsgrenze für Röntgenstrahlung und deren Nutzanwendung zur Verhütung von Schäden (German). Strahlenther Onkol 57:30–36

    Google Scholar 

  • Hombrink J, Frohlich D, Glatzel M et al. (2000) Prevention of radiation-induced diarrhea by smectite. Results of a double-blind randomized, placebo-controlled multicenter study (German). Strahlenther Onkol 176:173–179

    Article  PubMed  CAS  Google Scholar 

  • Hopewell JW (1997) The volume effect in radiotherapy: its biological significance. Br J Radiol 70:S32–S40

    PubMed  Google Scholar 

  • Hopewell JW, Trott KR (2000) Volume effects in radiobiology as applied to radiotherapy. Radiother Oncol 56:283–288

    Article  PubMed  CAS  Google Scholar 

  • Hopewell JW, Calvo W, Jaenke R et al. (1993) Microvasculature and radiation damage. Recent Results Cancer Res 130:1–16

    PubMed  CAS  Google Scholar 

  • Hopewell JW, Nyman J, Turesson I (2003) Time factor for acute tissue reactions following fractionated irradiation: a balance between repopulation and enhanced radiosensitivity. Int J Radiat Biol 79:513–524

    Article  PubMed  CAS  Google Scholar 

  • Joiner MC, Bentzen SM (2002) Time-dose relationships: the linear-quadratic approach. In: Steel GG (ed) Basic clinical radiobiology, 3rd edn. Arnold, London, pp 120–133

    Google Scholar 

  • Kase M (2001) Immunohistochemical studies on the expression of EGF and EGFR in irradiated mouse oral mucosa treated with KGF. Project Report, MSc Radiobiology Course, University College of London

    Google Scholar 

  • Kash KM, Mago R, Kunkel EJ (2005) Psychosocial oncology: supportive care for the cancer patient. Semin Oncol 32:211–218

    Article  PubMed  Google Scholar 

  • Kilic D, Egehan I, Ozenirler S et al. (2000) Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of sulphasalazine in preventing acute gastrointestinal complications due to radiotherapy. Radiother Oncol 57:125–129

    Article  PubMed  CAS  Google Scholar 

  • Kilic D, Ozenirler S, Egehan I et al. (2001) Sulfasalazine decreases acute gastrointestinal complications due to pelvic radiotherapy. Ann Pharmacother 35:806–810

    Article  PubMed  CAS  Google Scholar 

  • Kim TH, Cho KH, Pyo HR et al. (2005) Dose-volumetric parameters of acute esophageal toxicity in patients with lung cancer treated with three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 62:995–1002

    Article  PubMed  Google Scholar 

  • Kirwan JM, Symonds P, Green JA et al. (2003) A systematic review of acute and late toxicity of concomitant chemoradiation for cervical cancer. Radiother Oncol 68:217–226

    Article  PubMed  Google Scholar 

  • Komaki R, Lee JS, Milas L et al. (2004) Effects of amifostine on acute toxicity from concurrent chemotherapy and radiotherapy for inoperable non-small-cell lung cancer: report of a randomized comparative trial. Int J Radiat Oncol Biol Phys 58:1369–1377

    Article  PubMed  CAS  Google Scholar 

  • Kozelsky TF, Meyers GE, Sloan JA et al. (2003) Phase III double-blind study of glutamine versus placebo for the prevention of acute diarrhea in patients receiving pelvic radiation therapy. J Clin Oncol 21:1669–1674

    Article  PubMed  CAS  Google Scholar 

  • Lee HK, Vaporciyan AA, Cox JD et al. (2003) Postoperative pulmonary complications after preoperative chemoradiation for esophageal carcinoma: correlation with pulmonary dose-volume histogram parameters. Int J Radiat Oncol Biol Phys 57:1317–1322

    Article  PubMed  Google Scholar 

  • Lindegaard JC, Grau C (2000) Has the outlook improved for amifostine as a clinical radioprotector? Radiother Oncol 57:113–118

    Article  PubMed  CAS  Google Scholar 

  • Lord BI (2001) Radiation and haematopoietic growth factors. In: Dörr W (ed) Growth factors in the pathogenesis of radiation effects in normal tissues. Urban and Vogel, Munich, pp 17–24

    Google Scholar 

  • Maciejewski B, Zajusz A, Pilecki B et al. (1991) Acute mucositis in the stimulated oral mucosa of patients during radiotherapy for head and neck cancer. Radiother Oncol 22:7–11

    Article  PubMed  CAS  Google Scholar 

  • Maduro JH, Pras E, Willemse PH et al. (2003) Acute and longterm toxicity following radiotherapy alone or in combination with chemotherapy for locally advanced cervical cancer. Cancer Treat Rev 29:471–488

    Article  PubMed  CAS  Google Scholar 

  • Maranzano E, Feyer P, Molassiotis A et al. (2005) Evidencebased recommendations for the use of antiemetics in radiotherapy. Radiother Oncol 76:227–233

    Article  PubMed  CAS  Google Scholar 

  • Martenson JA, Bollinger JW, Sloan JA et al. (2000) Sucralfate in the prevention of treatment-induced diarrhea in patients receiving pelvic radiation therapy. J Clin Oncol 18:1239–1245

    PubMed  CAS  Google Scholar 

  • Martin T, Uhder K, Kurek R et al. (2002) Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial. Radiother Oncol 65:17–22

    Article  PubMed  CAS  Google Scholar 

  • Masucci G, Broman P, Kelly C et al. (2005) Therapeutic efficacy by recombinant human granulocyte/monocyte-colony stimulating factor on mucositis occurring in patients with oral and oropharynx tumors treated with curative radiotherapy: a multicenter open randomized phase III study. Med Oncol 22:247–256

    Article  PubMed  Google Scholar 

  • Michalowski A (1981) Effects of radiation on normal tissues: hypothetical mechanisms and limitations of in situ assays of clonogenicity. Radiat Environ Biophys 19:157–172

    Article  PubMed  CAS  Google Scholar 

  • Nieder C, Price RE, Rivera B et al. (2002) Experimental data for administration of insulin-like growth factor 1 (IGF-1) and basic fibroblast growth factor (bFGF) for prevention of radiation myelopathy (German). Strahlenther Onkol 178:147–152

    Article  PubMed  Google Scholar 

  • Nieder C, Andratschke NH, Wiedenmann N et al. (2004) Prevention of radiation-induced central nervous system toxicity: A role for amifostine? Anticancer Res 24:3803–3809

    PubMed  CAS  Google Scholar 

  • Nieder C, Price RE, Rivera B et al. (2005a) Effects of insulinlike growth factor-1 (IGF-1) and amifostine in spinal cord reirradiation. Strahlenther Onkol 181:691–695

    Article  PubMed  Google Scholar 

  • Nieder C, Zimmermann FB, Adam M et al. (2005b) The role of pentoxifylline as a modifier of radiation therapy. Cancer Treat Rev 31:448–455

    Article  PubMed  CAS  Google Scholar 

  • Nishimura Y (2004) Rationale for chemoradiotherapy. Int J Clin Oncol 9:414–420

    Article  PubMed  Google Scholar 

  • Parvez T, Almazaini A, Al Bouq Y et al. (2005) Scope of growth factor in cancer patients. J Coll Phys Surg Pak 15:375–377

    Google Scholar 

  • Patel AB, Edelman MJ, Kwok Y et al. (2004) Predictors of acute esophagitis in patients with non-small-cell lung carcinoma treated with concurrent chemotherapy and hyperfraction ated radiotherapy followed by surgery. Int J Radiat Oncol Biol Phys 60:1106–1112

    Article  PubMed  Google Scholar 

  • Prosnitz RG, Chen YH, Marks LB (2005) Cardiac toxicity following thoracic radiation. Semin Oncol 32:S71–S80

    Article  PubMed  Google Scholar 

  • Ravasco P, Monteiro-Grillo I, Vidal PM et al. (2005) Dietary counseling improves patient outcomes: a prospective, randomized, controlled trial in colorectal cancer patients undergoing radiotherapy. J Clin Oncol 23:1431–1438

    Article  PubMed  Google Scholar 

  • Resbeut M, Marteau P, Cowen D et al. (1997) A randomized double blind placebo controlled multicenter study of mesalazine for the prevention of acute radiation enteritis. Radiother Oncol 44:59–63

    Article  PubMed  CAS  Google Scholar 

  • Rodemann HP (2003) Role of radiation-induced signalling proteins in the response of vascular and connective tissues. In: Nieder C, Milas L, Ang KK (eds) Biological modification of radiation response. Springer, Berlin Heidelberg New York, pp 15–28

    Google Scholar 

  • Rodemann HP, Bamberg M (1995) Cellular basis of radiationinduced fibrosis. Radiother Oncol 35:83–90

    Article  PubMed  CAS  Google Scholar 

  • Rubenstein EB, Peterson DE, Schubert M et al. (2004) Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer 100:2026–2046

    Article  PubMed  Google Scholar 

  • Saarilahti K, Kajanti M, Joensuu T et al. (2002) Comparison of granulocyte-macrophage colony-stimulating factor and sucralfate mouthwashes in the prevention of radiationinduced mucositis: a double-blind prospective randomized phase III study. Int J Radiat Oncol Biol Phys 54:479–485

    Article  PubMed  CAS  Google Scholar 

  • Sagowski C, Wenzel S, Jenicke L et al. (2005) Sodium selenite is a potent radioptotector of the salivary glands of the rat: acute effects on the morphology and parenchymal function during fractionated irradiation. Eur Arch Otorhinolaryngol 262:459–464

    Article  PubMed  CAS  Google Scholar 

  • Sonis ST, Elting LS, Keefe D et al. (2004) Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100:1995–2025

    Article  PubMed  Google Scholar 

  • Spielberger R, Stiff P, Bensinger W et al. (2004) Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med 35:2590–2598

    Article  Google Scholar 

  • Staar S, Rudat V, Stützer H et al. (2001) Intensified hyperfractionated accelerated radiotherapy limits the additional benefit of simultaneous chemotherapy: results of a multicenter randomized German trial in advanced head and neck cancer. Int J Radiat Oncol Biol Phys 50:1161–1171

    Article  PubMed  CAS  Google Scholar 

  • Stellamans K, Lievens Y, Lambin P et al. (2002) Does sucralfate reduce early side effects of pelvic radiation? A double-blind randomized trial. Radiother Oncol 65:105–108

    Article  PubMed  CAS  Google Scholar 

  • Stewart FA, van der Kogel A (2002) Proliferative and cellular organisation of normal tissues. In: Steel GG (ed) Basic clinical radiobiology, 3rd edn. Arnold, London, pp 23–29

    Google Scholar 

  • Stokman MA, Spijkervet FK, Burlage FR et al. (2003) Oral mucositis and selective elimination of oral flora in head and neck cancer patients receiving radiotherapy: a doubleblind randomised clinical trial. Br J Cancer 88:1012–1016

    Article  PubMed  CAS  Google Scholar 

  • Su CK, Mehta V, Ravikumar L et al. (2004) Phase II doubleblind randomized study comparing oral aloe vera versus placebo to prevent radiation-induced mucositis in patients with head-and-neck neoplasms. Int J Radiat Oncol Biol Phys 60:171–177

    Article  PubMed  Google Scholar 

  • Suntharalingam M, Jaboin J, Taylor R et al. (2004) The evaluation of amifostine for mucosal protection in patients with advanced loco-regional squamous cell carcinomas of the head and neck (SCCHN) treated with concurrent weekly carboplatin, paclitaxel, and daily radiotherapy (RT). Semin Oncol 31(Suppl 18):2–7

    Article  PubMed  CAS  Google Scholar 

  • Takeda K, Nemoto K, Saito H et al. (2005) Dosimetric correlations of acute esophagitis in lung cancer patients treated with radiotherapy. 2: Int J Radiat Oncol Biol Phys 62:626–629

    Article  PubMed  Google Scholar 

  • Tannock IF (1996) Treatment of cancer with radiation and drugs. J Clin Oncol 14:3156–3174

    PubMed  CAS  Google Scholar 

  • Thames HD, Hendry JH (1987) Fractionation in radiotherapy. Taylor and Francis, London

    Google Scholar 

  • Thames HD, Withers HR, Peters LJ et al. (1982) Changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships. Int J Radiat Oncol Biol Phys 8:219–226

    PubMed  Google Scholar 

  • Thorstad WL, Chao KS, Haughey B (2004) Toxicity and compliance of subcutaneous amifostine in patients undergoing postoperative intensity-modulated radiation therapy for head and neck cancer. Semin Oncol 31(Suppl 18):8–12

    Article  PubMed  CAS  Google Scholar 

  • Trotti A, Garden A, Warde P et al. (2004) A multinational, randomized phase III trial of iseganan HCl oral solution for reducing the severity of oral mucositis in patients receiving radiotherapy for head-and-neck malignancy. Int J Radiat Oncol Biol Phys 58:674–681

    Article  PubMed  CAS  Google Scholar 

  • Tsujino K, Hirota S, Endo M et al. (2003) Predictive value of dose-volume histogram parameters for predicting radiation pneumonitis after concurrent chemoradiation for lung cancer. Int J Radiat Oncol Biol Phys 55:110–115

    Article  PubMed  Google Scholar 

  • Wang J, Zheng H, Sung CC et al. (1999) The synthetic somatostatin analogue, octreotide, ameliorates acute and delayed intestinal radiation injury. Int J Radiat Oncol Biol Phys 45:1289–1296

    Article  PubMed  CAS  Google Scholar 

  • Wang J, Zheng H, Hauer-Jensen M (2001) Influence of shortterm octreotide administration on chronic tissue injury, transforming growth factor beta (TGF-beta) overexpression, and collagen accumulation in irradiated rat intestine. J Pharmacol Exp Ther 297:35–42

    PubMed  CAS  Google Scholar 

  • Wasserman TH, Brizel DM, Henke M et al. (2005) Influence of intravenous amifostine on xerostomia, tumor control, and survival after radiotherapy for head-and-neck cancer: 2-year follow-up of a prospective, randomized, phase III trial. Int J Radiat Oncol Biol Phys 63:985–990

    Article  PubMed  CAS  Google Scholar 

  • Weiss JF, Srinivasan V, Kumar KS et al. (1992) Radioprotection by metals: selenium. Adv Space Res 12:223–231

    Article  PubMed  CAS  Google Scholar 

  • Welzel G, Steinvorth S, Wenz F (2005) Cognitive effects of chemotherapy and/or cranial irradiation in adults. Strahlenther Onkol 181:141–156

    Article  PubMed  Google Scholar 

  • Werner-Wasik M, Langer C, Movsas B (2005) Amifostine in chemoradiation therapy for non-small cell lung cancer: review of experience and design of a phase II trial assessing subcutaneous and intravenous bolus administration. Semin Oncol 32(Suppl 3):S105–S108

    Article  PubMed  CAS  Google Scholar 

  • Wheldon TE, Michalowski AS, Kirk J (1982) The effect of irradiation on function in self-renewing normal tissues with differing proliferative organisation. Br J Radiol 55:759–766

    Article  PubMed  CAS  Google Scholar 

  • Willner J, Jost A, Baier K et al. (2003) A little to a lot or a lot to a little? An analysis of pneumonitis risk from dose-volume histogram parameters of the lung in patients with lung cancer treated with 3-D conformal radiotherapy. Strahlenther Onkol 179:548–556

    Article  PubMed  Google Scholar 

  • Zimmermann FB, Geinitz H, Schill S et al. (2005) Stereotactic hypofractionated radiation therapy for stage I non-small cell lung cancer. Lung Cancer 48:107–114

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Faculty Carl Gustav Carus, University of Technology Dresden, Fetscherstrasse 74, PF 58, 01307, Dresden, Germany

    Wolfgang Dörr DVM, PhD (Professor)

  2. Klinik für Strahlentherapie und Radioonkologie, Marienhospital Herne, Ruhr-Universität Bochum, Hölkeskampring 40, 44625, Herne, Germany

    Dorothea Riesenbeck MD

  3. Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, München, Germany

    Carsten Nieder MD

Authors
  1. Wolfgang Dörr DVM, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dorothea Riesenbeck MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carsten Nieder MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford School of Medicine, 269 Campus Drive Center for Clinical Science and Research, Rm 1255, Stanford, CA, 94305-5152, USA

    J. Martin Brown PhD

  2. Department of Human Oncology, University of Wisconsin Hospital Medical School, 600 Highland Ave., K4 312-3684, Madison, WI, 53792, USA

    Minesh P. Mehta MD

  3. Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, München, Germany

    Carsten Nieder MD

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Dörr, W., Riesenbeck, D., Nieder, C. (2006). Early and Late Treatment-Induced Toxicity. In: Brown, J.M., Mehta, M.P., Nieder, C. (eds) Multimodal Concepts for Integration of Cytotoxic Drugs. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-35662-2_21

Download citation

  • DOI: https://doi.org/10.1007/3-540-35662-2_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-25655-7

  • Online ISBN: 978-3-540-35662-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation