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Nichtbakterielle Osteitiden: Akne und andere Hautmanifestationen

  • Conference paper
Fortschritte der praktischen Dermatologie und Venerologie

Part of the book series: Fortschritte der praktischen Dermatologie und Venerologie ((DERMATOLOGIE,volume 19))

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Zusammenfassung

Nichtbakterielle Knochenentzündungen werden in allen Altersgruppen beschrieben. Die chronisch rezidivierende multifokale Osteomyelitis ist eine Erkrankung vorwiegend des Kindes- und Adoleszentenalters, die dem rheumatischen Formenkreis zugeordnet wird. Es gibt erste Hinweise auf eine genetische Grundlage [28], [34].

Nichtbakterielle Osteitiden manifestieren sich mit einem oder mehreren Osteomyelitisherden. Etwa 15–20 % der Patienten entwickeln zeitlich unabhängig von den Erkrankungsschüben Hautmanifestationen in Form einer palmo-plantaren Pustulose, die dem Formenkreis der Psoriasis zugeordnet wird [45], [61], [67]. Auch bei anderen dermatologischen Krankheitsbildern wie Acne conglobata und Acne fulminans [47], Pyoderma gangraenosum [59] oder Sweet-Syndrom [20] werden nicht-bakterielle Osteitiden oder Arthritiden beschrieben.

Nach eigenen Untersuchungen [28], [34] fanden sich erste Hinweise, dass ein bislang unbekanntes Gen auf dem langen Arm des Chromosom 18 in der Ätiologie der Erkrankung eine Rolle spielt. Die genetische Studie wird fortgeführt und um das Spektrum weiterer steriler Osteitiden mit dermatologischen Manifestationen erweitert.

Das Krankheitsbild der chronisch rezidivierdenden multifokalen Osteomyelitis wurde erstmals1972 von Giedeon et al. [25] beschrieben und 1978 von Probst [64] so benannt. Seitdem sind zahlreiche Fallbeschreibungen und Übersichtsarbeiten [12], [31], [34], [35], [71], [72], [73], [74], [75], [76], [77], [78], [89], erschienen.

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Authors and Affiliations

  1. Klinikum der Universität München, Lindwurmstraße 4, D-80337, München, Germany

    Annette Jansson (Dr. med., Dr. von Haunersches Kinderspital) & Bernd H. Belohradsky (Prof. Dr. med., Dr. von Haunersches Kinderspital)

  2. Abteilung Medizinische Genetik, Klinikum der Universität München, Lindwurmstraße 4, D-80337, München, Germany

    Astrid Golla (Dr. med., and Dr. von Haunersches Kinderspital)

  3. Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München, Frauenlobstraße 9-11, D-80337, München, Germany

    Claudia Borelli (Dr. med.) & Gerd Plewig (Prof. Dr. med. Dr. h.c.)

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Gerd Plewig (Prof. Dr. med. Dr. h.c.)Peter Kaudewitz (Prof. Dr. med.)Christian A. Sander (Priv.-Doz. Dr. med.)

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Jansson, A., Belohradsky, B.H., Golla, A., Borelli, C., Plewig, G. (2005). Nichtbakterielle Osteitiden: Akne und andere Hautmanifestationen. In: Plewig, G., Kaudewitz, P., Sander, C.A. (eds) Fortschritte der praktischen Dermatologie und Venerologie. Fortschritte der praktischen Dermatologie und Venerologie, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-28691-8_39

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