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Imaging of Primary Appendiceal Neoplasms

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Imaging of Acute Appendicitis in Adults and Children

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

Primary appendiceal neoplasms are relatively uncommon but are being detected with increasing frequency as an incidental finding at cross-sectional imaging. Clinical presentation of acute appendicitis related to tumoral obstruction represents the other major clinical manifestation of primary appendiceal neoplasms. In either case, radiologists should be vigilant for imaging findings suggestive of underlying tumor. Mucoceles resulting from mucinous cystic neoplasms account for the majority of appendiceal neoplasms detected at cross-sectional imaging, whether manifesting as a symptomatic lesion or as an incidental finding. Other primary tumor types that may be encountered include colonic-type adenocarcinoma, carcinoid tumors (classic, tubular, or goblet cell varieties), and non-Hodgkin’s lymphoma, among others. In addition, non-neoplastic processes may mimic a tumor at imaging. This chapter will review the salient clinical and imaging features of primary appendiceal neoplasms.

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References

  • Bansal A, Zakhour HD (2006) Benign mesothelioma of the appendix: an incidental finding in a case of sigmoid diverticular disease. J Clin Pathol 59(1):108–110

    Article  PubMed  CAS  Google Scholar 

  • Buck JL, Sobin LH (1990) Carcinoids of the gastrointestinal tract. Radiographics 10(6):1081–1095

    PubMed  CAS  Google Scholar 

  • Carpenter BW (1991) Lymphoma of the appendix. Gastrointest Radiol 16(3):256–258

    Article  PubMed  CAS  Google Scholar 

  • Carr NJ, Sobin LH (1996) Unusual tumors of the appendix and pseudomyxoma peritonei. Semin Diagn Pathol 13(4):314–325

    PubMed  CAS  Google Scholar 

  • Carr NJ, McCarthy WF, Sobin LH (1995) Epithelial noncarcinoid tumors and tumor-like lesions of the appendix. A clinicopathologic study of 184 patients with a multivariate analysis of prognostic factors. Cancer 75(3):757–768

    Article  PubMed  CAS  Google Scholar 

  • Collins DC (1955) A study of 50, 000 specimens of the human vermiform appendix. Surg Gynecol Obstet 101(4):437–445

    PubMed  CAS  Google Scholar 

  • Connor SJ, Hanna GB, Frizelle FA (1998) Appendiceal tumors: retrospective clinicopathologic analysis of appendiceal tumors from 7, 970 appendectomies. Dis Colon Rectum 41(1):75–80

    Article  PubMed  CAS  Google Scholar 

  • Dachman AH, Lichtenstein JE, Friedman AC (1985) Mucocele of the appendix and pseudomyxoma peritonei. Am J Roentgenol 144(5):923–929

    CAS  Google Scholar 

  • Deans GT, Spence RA (1995) Neoplastic lesions of the appendix. Br J Surg 82(3):299–306

    Article  PubMed  CAS  Google Scholar 

  • Gonzalez JE, Hann SE, Trujillo YP (1988) Myxoglobulosis of the appendix. Am J Surg Pathol 12(12):962–966

    Article  PubMed  CAS  Google Scholar 

  • Hananel N, Powsner E, Wolloch Y (1998) Adenocarcinoma of the appendix: an unusual disease. Eur J Surg 164(11):859–862

    Article  PubMed  CAS  Google Scholar 

  • Hatch KF et al (2000) Tumors of the appendix and colon. World J Sur 24(4):430–436

    Article  CAS  Google Scholar 

  • Hebert JJ, Pickhardt PJ (2007) MDCT diagnosis of an appendiceal mucocele with acute torsion. Am J Roentgenol 189(1):W4–W6

    Article  Google Scholar 

  • Hermans JJ et al (1993) Appendicitis caused by carcinoid tumor. Radiology 188(1):71–72

    PubMed  CAS  Google Scholar 

  • Hinson FL, Ambrose NS (1998) Pseudomyxoma peritonei. Br J Surg 85(10):1332–1339

    Article  PubMed  CAS  Google Scholar 

  • Kim SH et al (1998) Mucocele of the appendix: ultrasonographic and CT findings. Abdom Imaging 23(3):292–296

    Article  PubMed  CAS  Google Scholar 

  • Ko YH et al (2008) Primary signet ring cell carcinoma of the appendix: a rare case report and our 18 year experience. World J Gastroenterol 14(37):5763–5768

    Article  PubMed  Google Scholar 

  • Koga H et al (1995) Appendiceal mucocele: sonographic and MR imaging findings. Am J Roentgenol 165(6):1552

    CAS  Google Scholar 

  • Krepel VM, van Erp WF, Vlasveld LT (1996) Lymphoma of the appendix: sonographic findings. Am J Roentgenol 167(1):286

    CAS  Google Scholar 

  • Lee SY et al (2010) Actinomycosis of the appendix mimicking appendiceal tumor: a case report. World J Gastroenterol 16(3):395–397

    Article  PubMed  CAS  Google Scholar 

  • Lim HK et al (1999) Primary mucinous cystadenocarcinoma of the appendix: CT findings. Am J Roentgenol 173(4):1071–1074

    CAS  Google Scholar 

  • Lockhart ME et al (2000) Appendiceal ganglioneuromas and pheochromocytoma in neurofibromatosis type 1. Am J Roentgenol 175(1):132–134

    CAS  Google Scholar 

  • Madwed D, Mindelzun R, Jeffrey RB Jr (1992) Mucocele of the appendix: imaging findings. Am J Roentgenol 159(1):69–72

    CAS  Google Scholar 

  • Mastoraki A et al (2010) A case of signet ring carcinoma of the appendix: dilemmas in differential diagnosis and management. J Gastrointest Cancer 41(2):141–144

    Article  PubMed  Google Scholar 

  • McCusker ME et al (2002) Primary malignant neoplasms of the appendix: a population-based study from the surveillance, epidemiology and end-results program, 1973–1998. Cancer 94(12):3307–3312

    Article  PubMed  Google Scholar 

  • McGory ML et al (2005) Malignancies of the appendix: beyond case series reports. Dis Colon Rectum 48(12):2264–2271

    Article  PubMed  Google Scholar 

  • Miettinen M, Sobin LH (2001) Gastrointestinal stromal tumors in the appendix: a clinicopathologic and immunohistochemical study of four cases. Am J Surg Pathol 25(11):1433–1437

    Article  PubMed  CAS  Google Scholar 

  • Moertel CG et al (1987) Carcinoid tumor of the appendix: treatment and prognosis. N Engl J Med 317(27):1699–1701

    Article  PubMed  CAS  Google Scholar 

  • Muller G et al (1997) Leukaemia and lymphoma of the appendix presenting as acute appendicitis or acute abdomen. Four case reports with a review of the literature. J Cancer Res Clin Oncol 123(10):560–564

    Article  PubMed  CAS  Google Scholar 

  • O’Kane AM et al (2008) Small cell carcinoma of the appendix. World J Surg Oncol 6:4

    Article  PubMed  Google Scholar 

  • Pham TH et al (2006) Surgical and chemotherapy treatment outcomes of goblet cell carcinoid: a tertiary cancer center experience. Ann Surg Oncol 13(3):370–376

    Article  PubMed  Google Scholar 

  • Pickhardt PJ et al (2002a) Primary neoplasms of the appendix manifesting as acute appendicitis: CT findings with pathologic comparison. Radiology 224(3):775–781

    Article  PubMed  Google Scholar 

  • Pickhardt PJ et al (2002b) Non-Hodgkin’s lymphoma of the appendix: clinical and CT findings with pathologic correlation. Am J Roentgenol 178(5):1123–1127

    Google Scholar 

  • Pickhardt PJ et al (2003) Primary neoplasms of the appendix: radiologic spectrum of disease with pathologic correlation. Radiographics 23(3):645–662

    Article  PubMed  Google Scholar 

  • Rutledge RH, Alexander JW (1992) Primary appendiceal malignancies: rare but important. Surgery 111(3):244–250

    PubMed  CAS  Google Scholar 

  • Sandor A, Modlin IM (1998) A retrospective analysis of 1570 appendiceal carcinoids. Am J Gastroenterol 93(3):422–428

    Article  PubMed  CAS  Google Scholar 

  • Suzuki J et al (2009) Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: report of a case. Surg Today 39(3):235–240

    Article  PubMed  Google Scholar 

  • Todd RD et al (2004) Incidence and predictors of appendiceal tumors in elderly males presenting with signs and symptoms of acute appendicitis. Am J Surg 188(5):500–504

    Article  PubMed  Google Scholar 

  • Tsujimura H et al (2000) Involvement of the appendix in a relapsed case of primary nasal NK/T-cell lymphoma. Leuk Lymphoma 37(5–6):633–634

    Article  PubMed  CAS  Google Scholar 

  • van Eeden S et al (2000) Gangliocytic paraganglioma of the appendix. Histopathology 36(1):47–49

    Article  PubMed  Google Scholar 

  • Walensky RP et al (1996) Pseudomyxoma peritonei. Am J Roentgenol 167(2):471–474

    CAS  Google Scholar 

  • Zebrowska G, Walsh NM (1991) Human immunodeficiency virus-related Kaposi’s sarcoma of the appendix and acute appendicitis. Report of a case and review of the literature. Arch Pathol Lab Med 115(11):1157–1160

    PubMed  CAS  Google Scholar 

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Correspondence to Perry J. Pickhardt .

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Potretzke, T.A., Pickhardt, P.J. (2012). Imaging of Primary Appendiceal Neoplasms. In: KEYZER, C., Gevenois, P. (eds) Imaging of Acute Appendicitis in Adults and Children. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2011_227

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  • DOI: https://doi.org/10.1007/174_2011_227

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-17871-9

  • Online ISBN: 978-3-642-17872-6

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