Abstract
The fetal brain is substantially different from the neonatal brain in terms of its structure and connectivity. Fetal MRI, beginning at 16–18 GW (gestational weeks), can be used to study fetal brain development and maturation in vivo. T2-weighted (T2W), T1-weighted (T1W), and diffusion-weighted (DW) imaging sequences can be used primarily to demonstrate morphology, parenchymal lamination, sulcation and gyration, the width of the subarachnoid spaces, and the size and shape of the midline structures. It is essential to understand MR signal changes associated with maturation, including the appearance and disappearance of transient structures, the underlying histological development of the fetal brain as well as the timing of development of landmarks in maturation in order to interpret normal and abnormal findings. It is the basis for understanding how neurogenetic development can be disrupted during vulnerable periods by different pathological processes, and how genetically controlled events in development correlate with functional development. The maturational stages of the fetal cerebral cortex, white matter, temporal lobe, and cerebellum, including structures that appear transiently in the developing brain as shown by various MR sequences, will be reviewed in this chapter.
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References
Abraham H, Tornoczky T et al (2001) Cell formation in the cortical layers of the developing human cerebellum. Int J Dev Neurosci 19(1):53–62
Adamsbaum C, Moutard ML et al (2005) MRI of the fetal posterior fossa. Pediatr Radiol 35(2):124–140
Alagappan R, Browning PD et al (1994) Distal lateral ventricular atrium: reevaluation of normal range. Radiology 193(2):405–408
Anjari M, Srinivasan L et al (2007) Diffusion tensor imaging with tract-based spatial statistics reveals local white matter abnormalities in preterm infants. Neuroimage 35(3):1021–1027
Arber S (2004) Subplate neurons: bridging the gap to function in the cortex. Trends Neurosci 27(3):111–113
Arnold SE, Trojanowski JQ (1996) Human fetal hippocampal development: I. Cytoarchitecture, myeloarchitecture, and neuronal morphologic features. J Comp Neurol 367(2):274–292
Back SA, Luo NL et al (2002) Arrested oligodendrocyte lineage progression during human cerebral white matter development: dissociation between the timing of progenitor differentiation and myelinogenesis. J Neuropathol Exp Neurol 61(2):197–211
Ballabh P, Braun A et al (2004) Anatomic analysis of blood vessels in germinal matrix, cerebral cortex, and white matter in developing infants. Pediatr Res 56(1):117–124
Barkovich AJ, Kjos BO et al (1988) Normal maturation of the neonatal and infant brain: MR imaging at 1.5 T. Radiology 166(1 Pt 1):173–180
Basson MA, Echevarria D et al (2008) Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development. Development 135(5):889–898
Battin M., Rutherford MA, (2001). MRI of the Fetal Brain. MA, Rutherford, Saunders Ltd.: 36–45
Battin MR, Maalouf EF et al (1998) Magnetic resonance imaging of the brain in very preterm infants: visualization of the germinal matrix, early myelination, and cortical folding. Pediatrics 101(6):957–962
Ben-Ari Y, Khalilov I et al (2004) Interneurons set the tune of developing networks. Trends Neurosci 27(7):422–427
Berman JI, Mukherjee P et al (2005) Quantitative diffusion tensor MRI fiber tractography of sensorimotor white matter development in premature infants. Neuroimage 27(4):862–871
Brazel CY, Romanko MJ et al (2003) Roles of the mammalian subventricular zone in brain development. Prog Neurobiol 69(1):49–69
Brisse H, Fallet C et al (1997) Supratentorial parenchyma in the developing fetal brain: in vitro MR study with histologic comparison. AJNR Am J Neuroradiol 18(8):1491–1497
Bronen RA, Cheung G (1991) MRI of the temporal lobe: normal variations, with special reference toward epilepsy. Magn Reson Imaging 9(4):501–507
Brugger PC, Stuhr F et al (2006) Methods of fetal MR: beyond T2-weighted imaging. Eur J Radiol 57(2):172–181
Bui T, Daire JL et al (2006) Microstructural development of human brain assessed in utero by diffusion tensor imaging. Pediatr Radiol 36(11):1133–1140
Bystron I, Rakic P et al (2006) The first neurons of the human cerebral cortex. Nat Neurosci 9(7):880–886
Bystron I, Blakemore C et al (2008) Development of the human cerebral cortex: Boulder Committee revisited. Nat Rev Neurosci 9(2):110–122
Cardoza GR, Goldstein RB, Filly RA (1988) Exclusion of fetal ventriculomegaly with a single measurement: the width of the lateral ventricular atrium. Radiology 169(3):711–714
Chi JG, Dooling EC et al (1977) Gyral development of the human brain. Ann Neurol 1(1):86–93
Childs AM, Ramenghi LA et al (2001) Cerebral maturation in premature infants: quantitative assessment using MR imaging. AJNR Am J Neuroradiol 22(8):1577–1582
Chong BW, Babcook CJ et al (1996) A magnetic resonance template for normal neuronal migration in the fetus. Neurosurgery 39(1):110–116
Chong BW, Babcook CJ et al (1997) A magnetic resonance template for normal cerebellar development in the human fetus. Neurosurgery 41(4):924–928, discussion 928-9
Chung R, Kasprian G et al (2009) The current state and future of fetal imaging. Clin Perinatol 36(3):685–699
Coleman KA, Mitrofanis J (1999) Does the perireticular thalamic nucleus project to the neocortex? Anat Embryol (Berl) 200(5):521–531
Corbin JG, Nery S et al (2001) Telencephalic cells take a tangent: non-radial migration in the mammalian forebrain. Nat Neurosci 4(Suppl):1177–1182
Counsell SJ, Maalouf EF et al (2002) MR imaging assessment of myelination in the very preterm brain. AJNR Am J Neuroradiol 23(5):872–881
Daffos F, Forestier F et al (1988) Fetal curarization for prenatal magnetic resonance imaging. Prenat Diagn 8(4):312–314
Del Rio JA, Martinez A et al (2000) Developmental history of the subplate and developing white matter in the murine neocortex. Neuronal organization and relationship with the main afferent systems at embryonic and perinatal stages. Cereb Cortex 10(8):784–801
Dorovini-Zis K, Dolman CL (1977) Gestational development of brain. Arch Pathol Lab Med 101(4):192–195
Dubois J, Benders M et al (2008) Mapping the early cortical folding process in the preterm newborn brain. Cereb Cortex 18(6):1444–1454
Earle KL, Mitrofanis J (1996) Genesis and fate of the perireticular thalamic nucleus during early development. J Comp Neurol 367(2):246–263
Eyre JA, Miller S et al (2000) Functional corticospinal projections are established prenatally in the human foetus permitting involvement in the development of spinal motor centres. Brain 123(Pt 1):51–64
Farrell TA, Hertzberg BS et al (1994) Fetal lateral ventricles: reassessment of normal values for atrial diameter at US. Radiology 193(2):409–411
Fields RD (2004) Volume transmission in activity-dependent regulation of myelinating glia. Neurochem Int 45(4):503–509
Filly RA, Goldstein RB (1994) The fetal ventricular atrium: fourth down and 10 mm to go. Radiology 193(2):315–317
Fischl B, Rajendran N et al (2008) Cortical folding patterns and predicting cytoarchitecture. Cereb Cortex 18(8):1973–1980
Fishell G, Mason CA et al (1993) Dispersion of neural progenitors within the germinal zones of the forebrain. Nature 362(6421):636–638
Fogliarini C, Chaumoitre K et al (2005) Assessment of cortical maturation with prenatal MRI. Part I: Normal cortical maturation. Eur Radiol 15(8):1671–1685
Garel C (2004) MRI of the fetal brain: normal development and cerebral pathologies. Springer-Verlag, Berlin Heidelberg
Garel C, Alberti C (2006) Coronal measurement of the fetal lateral ventricles: comparison between ultrasonography and magnetic resonance imaging. Ultrasound Obstet Gynecol 27(1):23–27
Garel C, Chantrel E et al (2001) Fetal cerebral cortex: normal gestational landmarks identified using prenatal MR imaging. AJNR Am J Neuroradiol 22(1):184–189
Garel C, Chantrel E et al (2003) Fetal MRI: normal gestational landmarks for cerebral biometry, gyration and myelination. Childs Nerv Syst 19(7–8):422–425
Garel C, Delezoide AL et al (2004) Contribution of fetal MR imaging in the evaluation of cerebral ischemic lesions. AJNR Am J Neuroradiol 25(9):1563–1568
Girard NJ, Raybaud CA (1992) In vivo MRI of fetal brain cellular migration. J Comput Assist Tomogr 16(2):265–267
Girard N, Raybaud C et al (1991) MRI study of brain myelination. J Neuroradiol 18(4):291–307
Girard N, Raybaud C et al (1995) In vivo MR study of brain maturation in normal fetuses. AJNR Am J Neuroradiol 16(2):407–413
Glenn OA, Barkovich AJ (2006) Magnetic resonance imaging of the fetal brain and spine: an increasingly important tool in prenatal diagnosis, part 1. AJNR Am J Neuroradiol 27(8):1604–1611
Grever WE, Chiu FC et al (1996) Quantification of myelin basic protein in the human fetal spinal cord during the midtrimester of gestation. J Comp Neurol 376(2):306–314
Gupta RK, Hasan KM et al (2005) Diffusion tensor imaging of the developing human cerebrum. J Neurosci Res 81(2):172–178
Hankin MH, Silver J (1988) Development of intersecting CNS fiber tracts: the corpus callosum and its perforating fiber pathway. J Comp Neurol 272(2):177–190
Hilgetag CC, Barbas H (2005) Developmental mechanics of the primate cerebral cortex. Anat Embryol (Berl) 210(5–6):411–417
Hofer S, Frahm J (2006) Topography of the human corpus callosum revisited–comprehensive fiber tractography using diffusion tensor magnetic resonance imaging. Neuroimage 32(3):989–994
Huang H, Zhang J et al (2006) White and gray matter development in human fetal, newborn and pediatric brains. Neuroimage 33(1):27–38
Huang H, Xue R et al (2009) Anatomical characterization of human fetal brain development with diffusion tensor magnetic resonance imaging. J Neurosci 29(13):4263–4273
Huppi PS, Maier SE et al (1998) Microstructural development of human newborn cerebral white matter assessed in vivo by diffusion tensor magnetic resonance imaging. Pediatr Res 44(4):584–590
Hynes RO, Patel R et al (1986) Migration of neuroblasts along preexisting axonal tracts during prenatal cerebellar development. J Neurosci 6(3):867–876
Isumi H, Mizuguchi M et al (1997) Differential development of the human cerebellar vermis: immunohistochemical and morphometrical evaluation. Brain Dev 19(4):254–257
Jakovcevski I, Zecevic N (2005) Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS. J Neurosci 25(44):10064–10073
Joseph R (2000) Fetal brain behavior and cognitive development. Dev Rev 20:81–98
Jovanov-Milosevic N, Culjat M et al (2009) Growth of the human corpus callosum: modular and laminar morphogenetic zones. Front Neuroanat 3:6
Judas M, Rados M et al (2005) Structural, immunocytochemical, and mr imaging properties of periventricular crossroads of growing cortical pathways in preterm infants. AJNR Am J Neuroradiol 26(10):2671–2684
Kasprian G (2006) Growth and development of the fetal temporal lobe in vivo. Medical University of Vienna, Vienna
Kasprian G, Brugger PC et al (2008) In utero tractography of fetal white matter development. Neuroimage 43(2):213–224
Kasprian G, Langs G et al (2010) The prenatal origin of hemispheric asymmetry: an in utero neuroimaging study. Cereb Cortex. [Epub ahead of print]
Katz MJ, Lasek RJ et al (1983) Ontophyletics of the nervous system: development of the corpus callosum and evolution of axon tracts. Proc Natl Acad Sci USA 80(19):5936–5940
Khazipov R, Esclapez M et al (2001) Early development of neuronal activity in the primate hippocampus in utero. J Neurosci 21(24):9770–9781
Kier EL, Truwit CL (1996) The normal and abnormal genu of the corpus callosum: an evolutionary, embryologic, anatomic, and MR analysis. AJNR Am J Neuroradiol 17(9):1631–1641
Kier EL, Truwit CL (1997) The lamina rostralis: modification of concepts concerning the anatomy, embryology, and MR appearance of the rostrum of the corpus callosum. AJNR Am J Neuroradiol 18(4):715–722
Kier EL, Kim JH et al (1997) Embryology of the human fetal hippocampus: MR imaging, anatomy, and histology. AJNR Am J Neuroradiol 18(3):525–532
Kinney HC (2005) Human myelination and perinatal white matter disorders. J Neurol Sci 228(2):190–192
Kinoshita Y, Okudera T et al (2001) Volumetric analysis of the germinal matrix and lateral ventricles performed using MR images of postmortem fetuses. AJNR Am J Neuroradiol 22(2):382–388
Koester SE, O’Leary DD (1994) Axons of early generated neurons in cingulate cortex pioneer the corpus callosum. J Neurosci 14(11 Pt 1):6608–6620
Kostovic I (1990) Structural and histochemical reorganization of the human prefrontal cortex during perinatal and postnatal life. Prog Brain Res 85:223–239, discussion 239–240
Kostovic I, Jovanov-Milosevic N (2008) Subplate zone of the human brain: historical perspective and new concepts. Coll Antropol 32(Suppl 1):3–8
Kostovic I, Judas M (1998) Transient patterns of organization of the human fetal brain. Croat Med J 39(2):107–114
Kostovic I, Judas M (2002) Correlation between the sequential ingrowth of afferents and transient patterns of cortical lamination in preterm infants. Anat Rec 267(1):1–6
Kostovic I, Judas M (2006) Prolonged coexistence of transient and permanent circuitry elements in the developing cerebral cortex of fetuses and preterm infants. Dev Med Child Neurol 48(5):388–393
Kostovic I, Vasung L (2009) Insights from in vitro fetal magnetic resonance imaging of cerebral development. Semin Perinatol 33(4):220–233
Kostovic I, Judas M et al (1995) Ontogenesis of goal-directed behavior: anatomo-functional considerations. Int J Psychophysiol 19(2):85–102
Kostovic I, Judas M et al (2002) Laminar organization of the human fetal cerebrum revealed by histochemical markers and magnetic resonance imaging. Cereb Cortex 12(5):536–544
Lan LM, Yamashita Y et al (2000) Normal fetal brain development: MR imaging with a half-Fourier rapid acquisition with relaxation enhancement sequence. Radiology 215(1):205–210
Larroche JC (1981) Morphological criteria of central nervous system development in the human foetus. J Neuroradiol 8(2):93–108
Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M (1986) MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 161(2):401–407
Lent R, Uziel D et al (2005) Cellular and molecular tunnels surrounding the forebrain commissures of human fetuses. J Comp Neurol 483(4):375–382
Letinic K, Kostovic I (1997) Transient fetal structure, the gangliothalamic body, connects telencephalic germinal zone with all thalamic regions in the developing human brain. J Comp Neurol 384(3):373–395
Letinic K, Rakic P (2001) Telencephalic origin of human thalamic GABAergic neurons. Nat Neurosci 4(9):931–936
Letinic K, Zoncu R et al (2002) Origin of GABAergic neurons in the human neocortex. Nature 417(6889):645–649
Levine D, Barnes PD (1999) Cortical maturation in normal and abnormal fetuses as assessed with prenatal MR imaging. Radiology 210(3):751–758
Levine D, Trop I et al (2002) MR imaging appearance of fetal cerebral ventricular morphology. Radiology 223(3):652–660
Levitt P (2003) Structural and functional maturation of the developing primate brain. J Pediatr 143(4 Suppl):S35–S45
Lindwall C, Fothergill T et al (2007) Commissure formation in the mammalian forebrain. Curr Opin Neurobiol 17(1):3–14
Lowery CL, Hardman MP et al (2007) Neurodevelopmental changes of fetal pain. Semin Perinatol 31(5):275–282
Maas LC, Mukherjee P et al (2004) Early laminar organization of the human cerebrum demonstrated with diffusion tensor imaging in extremely premature infants. Neuroimage 22(3):1134–1140
Manganaro L, Perrone A et al (2007) Evaluation of normal brain development by prenatal MR imaging. Radiol Med 112(3):444–455
Marin O, Rubenstein JL (2003) Cell migration in the forebrain. Annu Rev Neurosci 26:441–483
Marin-Padilla M (1990) Three-dimensional structural organization of layer I of the human cerebral cortex: a Golgi study. J Comp Neurol 299(1):89–105
Marin-Padilla M (1998) Cajal-Retzius cells and the development of the neocortex. Trends Neurosci 21(2):64–71
McKinstry RC, Mathur A et al (2002) Radial organization of developing preterm human cerebral cortex revealed by non-invasive water diffusion anisotropy MRI. Cereb Cortex 12(12):1237–1243
Menezes JR, Marins M et al (2002) Cell migration in the postnatal subventricular zone. Braz J Med Biol Res 35(12):1411–1421
Mihajlovic P, Zecevic N (1986) Development of the human dentate nucleus. Hum Neurobiol 5(3):189–197
Molnar Z, Blakemore C (1995) How do thalamic axons find their way to the cortex? Trends Neurosci 18(9):389–397
Mukherjee P, Miller JH et al (2002) Diffusion-tensor MR imaging of gray and white matter development during normal human brain maturation. AJNR Am J Neuroradiol 23(9):1445–1456
Muller F, O’Rahilly R (1988) The first appearance of the future cerebral hemispheres in the human embryo at stage 14. Anat Embryol (Berl) 177(6):495–511
Nakayama T, Yamada R (1999) MR imaging of the posterior fossa structures of human embryos and fetuses. Radiat Med 17(2):105–114
Nara T, Goto N et al (1996) Morphometric development of the human fetal auditory system: inferior collicular nucleus. Brain Dev 18(1):35–39
Olesen AG, Svare JA (2004) Decreased fetal movements: background, assessment, and clinical management. Acta Obstet Gynecol Scand 83(9):818–826
O’Rahilly R, Muller F (1999) Minireview: summary of the initial development of the human nervous system. Teratology 60(1):39–41
Parazzini C, Righini A et al (2008) Prenatal magnetic resonance imaging: brain normal linear biometric values below 24 gestational weeks. Neuroradiology 50(10):877–883
Partridge SC, Mukherjee P et al (2004) Diffusion tensor imaging: serial quantitation of white matter tract maturity in premature newborns. Neuroimage 22(3):1302–1314
Partridge SC, Mukherjee P et al (2005) Tractography-based quantitation of diffusion tensor imaging parameters in white matter tracts of preterm newborns. J Magn Reson Imaging 22(4):467–474
Penrice J, Cady EB et al (1996) Proton magnetic resonance spectroscopy of the brain in normal preterm and term infants, and early changes after perinatal hypoxia-ischemia. Pediatr Res 40(1):6–14
Petanjek Z, Dujmovic A et al (2008) Distinct origin of GABA-ergic neurons in forebrain of man, nonhuman primates and lower mammals. Coll Antropol 32(Suppl 1):9–17
Plachez C, Richards LJ (2005) Mechanisms of axon guidance in the developing nervous system. Curr Top Dev Biol 69:267–346
Prayer D, Prayer L (2003) Diffusion-weighted magnetic resonance imaging of cerebral white matter development. Eur J Radiol 45(3):235–243
Prayer D, Brugger PC et al (2005) Triangular crossroads: a “Wetterwinkel” of the fetal brain. American Society of Neuroradiology, Toronto
Prayer D, Kasprian G et al (2006) MRI of normal fetal brain development. Eur J Radiol 57(2):199–216
Rados M, Judas M et al (2006) In vitro MRI of brain development. Eur J Radiol 57(2):187–198
Rakic P (2003) Developmental and evolutionary adaptations of cortical radial glia. Cereb Cortex 13(6):541–549
Rakic P (2004) Neuroscience. Genetic control of cortical convolutions. Science 303(5666):1983–1984
Rakic P, Yakovlev PI (1968) Development of the corpus callosum and cavum septi in man. J Comp Neurol 132(1):45–72
Raybaud C (2010) The corpus callosum, the other great forebrain commissures, and the septum pellucidum: anatomy, development, and malformation. Neuroradiology 52(6):447–477
Ren T, Anderson A et al (2006) Imaging, anatomical, and molecular analysis of callosal formation in the developing human fetal brain. Anat Rec A Discov Mol Cell Evol Biol 288(2):191–204
Richards LJ (2002) Axonal pathfinding mechanisms at the cortical midline and in the development of the corpus callosum. Braz J Med Biol Res 35(12):1431–1439
Richards LJ, Koester SE et al (1997) Directed growth of early cortical axons is influenced by a chemoattractant released from an intermediate target. J Neurosci 17(7):2445–2458
Richards LJ, Plachez C et al (2004) Mechanisms regulating the development of the corpus callosum and its agenesis in mouse and human. Clin Genet 66(4):276–289
Righini A, Bianchini E et al (2003) Apparent diffusion coefficient determination in normal fetal brain: a prenatal MR imaging study. AJNR Am J Neuroradiol 24(5):799–804
Righini A, Zirpoli S et al (2006) Hippocampal infolding angle changes during brain development assessed by prenatal MR imaging. AJNR Am J Neuroradiol 27(10):2093–2097
Righini A, Parazzini C et al (2009) Prenatal MR imaging of the normal pituitary stalk. AJNR Am J Neuroradiol 30(5):1014–1016
Rutherford M, Jiang S et al (2008) MR imaging methods for assessing fetal brain development. Dev Neurobiol 68(6):700–711
Samuelsen GB, Larsen KB et al (2003) The changing number of cells in the human fetal forebrain and its subdivisions: a stereological analysis. Cereb Cortex 13(2):115–122
Sasaki M, Sone M et al (1993) Hippocampal sulcus remnant: potential cause of change in signal intensity in the hippocampus. Radiology 188(3):743–746
Schmook MT, Brugger PC et al (2010) Forebrain development in fetal MRI: evaluation of anatomical landmarks before gestational week 27. Neuroradiology 52(6):495–504
Schneider JF, Confort-Gouny S et al (2007) Diffusion-weighted imaging in normal fetal brain maturation. Eur Radiol 17(9):2422–2429
Schneider MM, Berman JI et al (2009) Normative apparent diffusion coefficient values in the developing fetal brain. AJNR Am J Neuroradiol 30(9):1799–1803
Shen WB, Plachez C et al (2006) Identification of candidate genes at the corticoseptal boundary during development. Gene Expr Patterns 6(5):471–481
Shiraishi K, Itoh M et al (2003) Myelination of a fetus with Pelizaeus-Merzbacher disease: immunopathological study. Ann Neurol 54(2):259–262
Shu T, Richards LJ (2001) Cortical axon guidance by the glial wedge during the development of the corpus callosum. J Neurosci 21(8):2749–2758
Shu T, Puche AC et al (2003) Development of midline glial populations at the corticoseptal boundary. J Neurobiol 57(1):81–94
Sidman RL, Rakic P (1973) Neuronal migration, with special reference to developing human brain: a review. Brain Res 62(1):1–35
Silver J, Lorenz SE et al (1982) Axonal guidance during development of the great cerebral commissures: descriptive and experimental studies, in vivo, on the role of preformed glial pathways. J Comp Neurol 210(1):10–29
Simonati A, Tosati C et al (1999) Cell proliferation and death: morphological evidence during corticogenesis in the developing human brain. Microsc Res Tech 45(6):341–352
Sotelo C (2004) Cellular and genetic regulation of the development of the cerebellar system. Prog Neurobiol 72(5):295–339
Sparling JW, Van Tol J et al (1999) Fetal and neonatal hand movement. Phys Ther 79(1):24–39
Stazzone MM, Hubbard AM et al (2000) Ultrafast MR imaging of the normal posterior fossa in fetuses. AJR Am J Roentgenol 175(3):835–839
Super H, Uylings HB (2001) The early differentiation of the neocortex: a hypothesis on neocortical evolution. Cereb Cortex 11(12):1101–1109
Sur M, Rubenstein JL (2005) Patterning and plasticity of the cerebral cortex. Science 310(5749):805–810
ten Donkelaar HJ (2000) Major events in the development of the forebrain. Eur J Morphol 38(5):301–308
ten Donkelaar HJ, Lammens M (2009) Development of the human cerebellum and its disorders. Clin Perinatol 36(3):513–530
ten Donkelaar HJ, Lammens M et al (2003) Development and developmental disorders of the human cerebellum. J Neurol 250(9):1025–1036
Tilea B, Alberti C et al (2009) Cerebral biometry in fetal magnetic resonance imaging: new reference data. Ultrasound Obstet Gynecol 33(2):173–181
Toi A, Lister WS et al (2004) How early are fetal cerebral sulci visible at prenatal ultrasound and what is the normal pattern of early fetal sulcal development? Ultrasound Obstet Gynecol 24(7):706–715
Toro R, Burnod Y (2005) A morphogenetic model for the development of cortical convolutions. Cereb Cortex 15(12):1900–1913
Triulzi F, Parazzini C et al (2005) MRI of fetal and neonatal cerebellar development. Semin Fetal Neonatal Med 10(5):411–420
Tulay CM, Elevli L et al (2004) Morphological study of the perireticular nucleus in human fetal brains. J Anat 205(1):57–63
Twickler DM, Reichel T et al (2002) Fetal central nervous system ventricle and cisterna magna measurements by magnetic resonance imaging. Am J Obstet Gynecol 187(4):927–931
Ulfig N (2000) The ganglionic eminence – new vistas. Trends Neurosci 23(11):530
Ulfig N (2002) The ganglionic eminence – a putative intermediate target of amygdaloid connections. Brain Res Dev Brain Res 139(2):313–318
van der Knaap MS, van Wezel-Meijler G et al (1996) Normal gyration and sulcation in preterm and term neonates: appearance on MR images. Radiology 200(2):389–396
Van Essen DC (1997) A tension-based theory of morphogenesis and compact wiring in the central nervous system. Nature 385(6614):313–318
Widjaja E, Geibprasert S et al (2010a) Alteration of human fetal subplate layer and intermediate zone during normal development on MR and diffusion tensor imaging. AJNR Am J Neuroradiol 31(6):1091–1099
Widjaja E, Geibprasert S et al (2010b) Corroboration of normal and abnormal fetal cerebral lamination on postmortem MR imaging with postmortem examination. AJNR Am J Neuroradiol 0: ajnr.A2193v1-0
Wimberger DM, Roberts TP et al (1995) Identification of “premyelination” by diffusion-weighted MRI. J Comput Assist Tomogr 19(1):28–33
Yamaguchi K, Goto N (1997) Three-dimensional structure of the human cerebellar dentate nucleus: a computerized reconstruction study. Anat Embryol (Berl) 196(4):343–348
Yoo SS, Park HJ et al (2005) In vivo visualization of white matter fiber tracts of preterm- and term-infant brains with diffusion tensor magnetic resonance imaging. Invest Radiol 40(2):110–115
Zecevic N (1993) Cellular composition of the telencephalic wall in human embryos. Early Hum Dev 32(2–3):131–149
Zecevic N, Milosevic A et al (1999) Early development and composition of the human primordial plexiform layer: An immunohistochemical study. J Comp Neurol 412(2):241–254
Zhai G, Lin W et al (2003) Comparisons of regional white matter diffusion in healthy neonates and adults performed with a 3.0-T head-only MR imaging unit. Radiology 229(3):673–681
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Pugash, D., Nemec, U., Brugger, P.C., Prayer, D. (2010). Fetal MRI of Normal Brain Development. In: Prayer, D. (eds) Fetal MRI. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2010_116
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