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Fundamentals of the Dynorphins/Kappa Opioid Receptor System: From Distribution to Signaling and Function

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The Kappa Opioid Receptor

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 271))

Abstract

This chapter provides a general introduction to the dynorphins (DYNs)/kappa opioid receptor (KOR) system, including DYN peptides, neuroanatomy of the DYNs/KOR system, cellular signaling, and in vivo behavioral effects of KOR activation and inhibition. It is intended to serve as a primer for the book and to provide a basic background for the chapters in the book.

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Acknowledgements

The writing of this manuscript was supported by the NIH Grants R01DA041781, 1UG3TR003148-01, and 2P50 DA005010, and the Department of Defense Grant W81XWH-15-1-0435 (CMC), the National Institute of Mental Health Intramural Research Program and a Brain and Behavior Research Foundation NARSAD Young Investigator Award (HAT), the Austrian Science Fund (FWF: I4697) (MS), the NIH grants R01DA041359, R21DA045274, and P30DA013429 (LYLC).

Conflict of Interests: The authors declare no conflict of interests.

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Authors and Affiliations

  1. Department of Psychiatry and Biobehavioral Sciences, Shirley and Stefan Hatos Center for Neuropharmacology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA

    Catherine Cahill

  2. Unit on Neuromodulation and Synaptic Integration, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA

    Hugo A. Tejeda

  3. Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria

    Mariana Spetea

  4. Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA

    Chongguang Chen & Lee-Yuan Liu-Chen

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  1. Catherine Cahill
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  3. Mariana Spetea
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  4. Chongguang Chen
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  5. Lee-Yuan Liu-Chen
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Correspondence to Lee-Yuan Liu-Chen .

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  1. Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA

    Lee-Yuan Liu-Chen

  2. Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA

    Saadet Inan

1 Electronic Supplementary Material

A video clip of 3-D images of KtdT/KtdT mouse brains showing KtdT distribution. Adult KtdT/KtdT mice were perfused and brains were cleared via CLARITY. Brains were imaged without IHC from dorsal and ventral sides and images were digitally re-constructed into 3-D images. Experiments were performed on three brains with similar results. [Reproduced from Chen et al. (2020)]. (MP4 41963 kb)

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Cahill, C., Tejeda, H.A., Spetea, M., Chen, C., Liu-Chen, LY. (2021). Fundamentals of the Dynorphins/Kappa Opioid Receptor System: From Distribution to Signaling and Function. In: Liu-Chen, LY., Inan, S. (eds) The Kappa Opioid Receptor. Handbook of Experimental Pharmacology, vol 271. Springer, Cham. https://doi.org/10.1007/164_2021_433

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