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The Kappa Opioid Receptor

  • Book
  • © 2022

Overview

Editors:
  1. Lee-Yuan Liu-Chen

    1. Lewis Katz School of Medicine, Temple University, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Saadet Inan

    1. Lewis Katz School of Medicine, Temple University, Philadelphia, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides recent advances in kappa opioid receptor (KOR) structure and signaling
  • Highlights advancements in preclinical research on KOR agonists and antagonists in experimental animal models
  • Summarizes development of KOR agonists/antagonists for clinical use (chronic itch, substance abuse, psych. diseases)

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 271)

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About this book

This book covers the latest knowledge in structure, signaling, and biochemical pharmacology of KOR as well as preclinical research and clinical applications (including clinical phase studies and approved for human use) of KOR compounds. It is divided up into the three parts: Molecular aspects of KOR, Preclinical research on pharmacology of KOR agonists and antagonists in animals and KOR agonists and antagonists in clinical use and in past and present clinical trials.
The chapters "Biosensors monitor ligand-selective effects at kappa opioid receptors" and "The role of dynorphin and the kappa opioid receptor in schizophrenia and major depressive disorder: a translational approach" of this book are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.




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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xi
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  2. Basics

    1. Front Matter

      Pages 1-1
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    2. Fundamentals of the Dynorphins/Kappa Opioid Receptor System: From Distribution to Signaling and Function

      • Catherine Cahill, Hugo A. Tejeda, Mariana Spetea, Chongguang Chen, Lee-Yuan Liu-Chen
      Pages 3-21

    3. Considerations on Using Antibodies for Studying the Dynorphins/Kappa Opioid Receptor System

      • Chongguang Chen, Melanie Widmann, Christoph Schwarzer, Lee-Yuan Liu-Chen
      Pages 23-38

  3. In Vitro Studies

    1. Front Matter

      Pages 39-39
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    2. Structural Characterization of KOR Inactive and Active States for 3D Pharmacology and Drug Discovery

      • Saheem A. Zaidi, Vsevolod Katritch
      Pages 41-64

    3. Biosensors Monitor Ligand-Selective Effects at Kappa Opioid Receptors

      • Lucie Oberhauser, Miriam Stoeber
      Pages 65-82Open Access

    4. Does GEC1 Enhance Expression and Forward Trafficking of the Kappa Opioid Receptor (KOR) via Its Ability to Interact with NSF Directly?

      • Peng Huang, Chunxia Zhao, Chongguang Chen, Sidney W. Whiteheart, Lee-Yuan Liu-Chen
      Pages 83-96

    5. Kappa Opioid Receptor Mediated Differential Regulation of Serotonin and Dopamine Transporters in Mood and Substance Use Disorder

      • Durairaj Ragu Varman, Lankupalle D. Jayanthi, Sammanda Ramamoorthy
      Pages 97-112

  4. Preclinical Drug Development

    1. Front Matter

      Pages 113-113
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    2. Biased Ligands at the Kappa Opioid Receptor: Fine-Tuning Receptor Pharmacology

      • Tarsis F. Brust
      Pages 115-135

    3. Preclinical Studies on Nalfurafine (TRK-820), a Clinically Used KOR Agonist

      • Yan Zhou, Kevin Freeman, Vincent Setola, Danni Cao, Shane Kaski, Mary Jeanne Kreek et al.
      Pages 137-162

    4. Kappa Opioid Receptor Ligands and Pharmacology: Diphenethylamines, a Class of Structurally Distinct, Selective Kappa Opioid Ligands

      • Mariana Spetea, Helmut Schmidhammer
      Pages 163-195

    5. Peptide Kappa Opioid Receptor Ligands and Their Potential for Drug Development

      • Jane V. Aldrich, Jay P. McLaughlin
      Pages 197-220

  5. Preclinical Studies: In Vivo Pharmacology

    1. Front Matter

      Pages 221-221
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    2. Dynorphin/Kappa-Opioid Receptor System Modulation of Cortical Circuitry

      • Hugo A. Tejeda, Huikun Wang, Rodolfo J. Flores, Hector E. Yarur
      Pages 223-253

    3. Molecular Genetics of Kappa Opioids in Pain and Itch Sensations

      • Pang-Yen Tseng, Mark A. Hoon
      Pages 255-274

    4. Antipruritic Effects of Kappa Opioid Receptor Agonists: Evidence from Rodents to Humans

      • Saadet Inan, Alan Cowan
      Pages 275-292

    5. Antinociceptive Effects of Kappa-Opioid Receptor Agonists

      • Matthew F. Lazenka
      Pages 293-313

    6. Kappa Opioid Signaling at the Crossroads of Chronic Pain and Opioid Addiction

      • Catherine M. Cahill, Lindsay Lueptow, Hannah Kim, Raj Shusharla, Amy Bishop, Christopher J. Evans
      Pages 315-350
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Editors and Affiliations

  • Lewis Katz School of Medicine, Temple University, Philadelphia, USA

    Lee-Yuan Liu-Chen, Saadet Inan

Bibliographic Information

  • Book Title: The Kappa Opioid Receptor

  • Editors: Lee-Yuan Liu-Chen, Saadet Inan

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-030-89074-2

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022

  • Hardcover ISBN: 978-3-030-89073-5Published: 25 November 2021

  • Softcover ISBN: 978-3-030-89076-6Published: 26 November 2022

  • eBook ISBN: 978-3-030-89074-2Published: 25 November 2021

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XI, 577

  • Number of Illustrations: 70 b/w illustrations, 30 illustrations in colour

  • Topics: Pharmacology/Toxicology

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