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BAT Exosomes: Metabolic Crosstalk with Other Organs and Biomarkers for BAT Activity

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Brown Adipose Tissue

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 251))

Abstract

In the last decade, exosomes have gained interest as a new type of intercellular communication between cells and tissues. Exosomes are circulating, cell-derived lipid vesicles smaller than 200 nm that contain proteins and nucleic acids, including microRNAs (miRNAs), and are able to modify cellular targets. Exosomal miRNAs function as signalling molecules that regulate the transcription of their target genes and can cause phenotypic transformation of recipient cells. Recent studies have shown that brown fat secretes exosomes as a form of communication with other metabolic organs such as the liver. Moreover, it has been shown that levels of miRNAs in BAT-derived exosomes change after BAT activation in vitro and in vivo. Thus, BAT-derived exosomes can be used as potential biomarkers of BAT activity. Here, we review the present knowledge about BAT-derived exosomes and their role in metabolism.

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Authors and Affiliations

  1. Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, Bonn, Germany

    Deborah Goody & Alexander Pfeifer

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  1. Deborah Goody
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  2. Alexander Pfeifer
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Correspondence to Alexander Pfeifer .

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  1. Institute of Pharmacology & Toxicology, University Hospital Bonn, University of Bonn, Bonn, Germany

    Alexander Pfeifer

  2. Institute of Molecular Nutritional Medicine, TU München, Freising, Bayern, Germany

    Martin Klingenspor

  3. Institute for Diabetes and Cancer IDC, Helmholtz Center München, Neuherberg, Germany

    Stephan Herzig

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Goody, D., Pfeifer, A. (2018). BAT Exosomes: Metabolic Crosstalk with Other Organs and Biomarkers for BAT Activity. In: Pfeifer, A., Klingenspor, M., Herzig, S. (eds) Brown Adipose Tissue. Handbook of Experimental Pharmacology, vol 251. Springer, Cham. https://doi.org/10.1007/164_2018_114

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