Abstract
A two-fluid theoretical model was developed to simulate the hydrodynamic focusing process formed by the coflowing sample and sheath fluids in a flow cytometer. The analysis consists of two groups of time-dependent three-dimensional conservation equations of mass and momentum. To validate the computer code, the predicted focused width in the two-dimensional test configuration was compared with Lee et al.’s measured data. The present study also examines the pressure distribution of the three-dimensional hydrodynamic focusing flowfield. For the u Sh /u S ratio ranging from 10 to 80, the focused width was determined to explore the applicability of the proposed flow cytometer.
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Yang, AS., Wu, CY. (2006). Computational Design Approach to Hydrodynamic Focusing in a Flow Cytometer. In: Huang, DS., Li, K., Irwin, G.W. (eds) Computational Intelligence and Bioinformatics. ICIC 2006. Lecture Notes in Computer Science(), vol 4115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11816102_37
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DOI: https://doi.org/10.1007/11816102_37
Publisher Name: Springer, Berlin, Heidelberg
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