Abstract
In recent years, it has been shown that breast cancer consists not only of neoplastic cells, but also of significant alterations in the surrounding stroma or tumor microenvironment. These alterations are now recognized as a critical element for breast cancer development and progression, as well as potential therapeutic targets. Furthermore, there is no doubt that ion channels are deregulated in breast cancer and some of which are prognostic markers of clinical outcome. Their dysregulation is also associated with aberrant signaling pathways. The number of published data on ion channels modifications by the microenvironment has significantly increased last years. Here, we summarize the state of the art on the cross talk between the tumor microenvironment and ion channels, in particular collagen 1, EGF, TGF-β, ATP, hypoxia, and pH, on the development and progression of breast cancer.
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Abbreviations
- BC:
-
Breast cancer
- DDR:
-
Discoidin domain receptor
- ECM:
-
Extracellular matrix
- EGF:
-
Epidermal growth factor
- EGFR:
-
Epidermal growth factor receptor
- EMT:
-
Epithelial-to-mesenchymal transition
- ER:
-
Endoplasmic reticulum
- GSTO1:
-
Glutathione S-transferase omega 1
- HIF:
-
Hypoxia inducible factor
- MCU:
-
Mitochondrial calcium uniporter
- MMP:
-
Metalloproteinase
- ROS:
-
Reactive oxygen species
- SICE:
-
Store-independent calcium entry
- TGF-β:
-
Transforming growth factor β
- TME:
-
Tumor microenvironment
- TNBC:
-
Triple-negative breast cancer
- VEGF:
-
Vascular endothelial growth factor
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Acknowledgments
This work was supported by the UPJV “Université de Picardie Jules Verne,” the “Région Hauts-de-France,” the CNO (“Cancéropôle Nord-Ouest”), and the Marie Skłodowska-Curie Innovative Training Network (ITN), Grant Agreement number: 813834 – pHioniC – H2020-MSCA-ITN-2018.
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The authors declare that they have no conflict of interest.
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Ouadid-Ahidouch, H., Morjani, H., Schnipper, J., Girault, A., Ahidouch, A. (2020). Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression. In: Stock, C., Pardo, L.A. (eds) Transportome Malfunction in the Cancer Spectrum. Reviews of Physiology, Biochemistry and Pharmacology, vol 181. Springer, Cham. https://doi.org/10.1007/112_2020_19
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DOI: https://doi.org/10.1007/112_2020_19
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